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<!-- Copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California.  All rights reserved.
     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
-->
<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="HALLMARK_INFLAMMATORY_RESPONSE" SYSTEMATIC_NAME="M5932" HISTORICAL_NAMES="" PMID="26771021" AUTHORS="Liberzon A,Birger C,Thorvaldsdóttir H,Ghandi M,Mesirov JP,Tamayo P" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes defining inflammatory response." DESCRIPTION_FULL="" TAGS="" MEMBERS="ABCA1,ABI1,ACVR1B,ACVR2A,ADM,ADORA2B,ADRM1,AHR,APLNR,AQP9,ATP2A2,ATP2B1,ATP2C1,AXL,BDKRB1,BEST1,BST2,BTG2,C3AR1,C5AR1,CALCRL,CCL17,CCL2,CCL20,CCL22,CCL24,CCL5,CCL7,CCR7,CCRL2,CD14,CD40,CD48,CD55,CD69,CD70,CD82,CDKN1A,CHST2,CLEC5A,CMKLR1,CSF1,CSF3,CSF3R,CX3CL1,CXCL10,CXCL11,CXCL6,CXCL9,CXCR6,CYBB,DCBLD2,EBI3,EDN1,EIF2AK2,EMP3,EMR1,EREG,F3,FFAR2,FPR1,FZD5,GABBR1,GCH1,GNA15,GNAI3,GP1BA,GPC3,GPR132,GPR183,HAS2,HBEGF,HIF1A,HPN,HRH1,ICAM1,ICAM4,ICOSLG,IFITM1,IFNAR1,IFNGR2,IL10,IL10RA,IL12B,IL15,IL15RA,IL18,IL18R1,IL18RAP,IL1A,IL1B,IL1R1,IL2RB,IL4R,IL6,IL7R,IL8,INHBA,IRAK2,IRF1,IRF7,ITGA5,ITGB3,ITGB8,KCNA3,KCNJ2,KCNMB2,KIF1B,KLF6,LAMP3,LCK,LCP2,LDLR,LIF,LPAR1,LTA,LY6E,LYN,MARCO,MEFV,MEP1A,MET,MMP14,MSR1,MXD1,MYC,NAMPT,NDP,NFKB1,NFKBIA,NLRP3,NMI,NMUR1,NOD2,NPFFR2,OLR1,OPRK1,OSM,OSMR,P2RX4,P2RX7,P2RY2,PCDH7,PDE4B,PDPN,PIK3R5,PLAUR,PROK2,PSEN1,PTAFR,PTGER2,PTGER4,PTGIR,PTPRE,PVR,RAF1,RASGRP1,RELA,RGS1,RGS16,RHOG,RIPK2,RNF144B,ROS1,RTP4,SCARF1,SCN1B,SELE,SELL,SELS,SEMA4D,SERPINE1,SGMS2,SLAMF1,SLC11A2,SLC1A2,SLC28A2,SLC31A1,SLC31A2,SLC4A4,SLC7A1,SLC7A2,SPHK1,SRI,STAB1,TACR1,TACR3,TAPBP,TIMP1,TLR1,TLR2,TLR3,TNFAIP6,TNFRSF1B,TNFRSF9,TNFSF10,TNFSF15,TNFSF9,TPBG,VIP" MEMBERS_SYMBOLIZED="ABCA1,ABI1,ACVR1B,ACVR2A,ADGRE1,ADM,ADORA2B,ADRM1,AHR,APLNR,AQP9,ATP2A2,ATP2B1,ATP2C1,AXL,BDKRB1,BEST1,BST2,BTG2,C3AR1,C5AR1,CALCRL,CCL17,CCL2,CCL20,CCL22,CCL24,CCL5,CCL7,CCR7,CCRL2,CD14,CD40,CD48,CD55,CD69,CD70,CD82,CDKN1A,CHST2,CLEC5A,CMKLR1,CSF1,CSF3,CSF3R,CX3CL1,CXCL10,CXCL11,CXCL6,CXCL8,CXCL9,CXCR6,CYBB,DCBLD2,EBI3,EDN1,EIF2AK2,EMP3,EREG,F3,FFAR2,FPR1,FZD5,GABBR1,GCH1,GNA15,GNAI3,GP1BA,GPC3,GPR132,GPR183,HAS2,HBEGF,HIF1A,HPN,HRH1,ICAM1,ICAM4,ICOSLG,IFITM1,IFNAR1,IFNGR2,IL10,IL10RA,IL12B,IL15,IL15RA,IL18,IL18R1,IL18RAP,IL1A,IL1B,IL1R1,IL2RB,IL4R,IL6,IL7R,INHBA,IRAK2,IRF1,IRF7,ITGA5,ITGB3,ITGB8,KCNA3,KCNJ2,KCNMB2,KIF1B,KLF6,LAMP3,LCK,LCP2,LDLR,LIF,LPAR1,LTA,LY6E,LYN,MARCO,MEFV,MEP1A,MET,MMP14,MSR1,MXD1,MYC,NAMPT,NDP,NFKB1,NFKBIA,NLRP3,NMI,NMUR1,NOD2,NPFFR2,OLR1,OPRK1,OSM,OSMR,P2RX4,P2RX7,P2RY2,PCDH7,PDE4B,PDPN,PIK3R5,PLAUR,PROK2,PSEN1,PTAFR,PTGER2,PTGER4,PTGIR,PTPRE,PVR,RAF1,RASGRP1,RELA,RGS1,RGS16,RHOG,RIPK2,RNF144B,ROS1,RTP4,SCARF1,SCN1B,SELE,SELENOS,SELL,SEMA4D,SERPINE1,SGMS2,SLAMF1,SLC11A2,SLC1A2,SLC28A2,SLC31A1,SLC31A2,SLC4A4,SLC7A1,SLC7A2,SPHK1,SRI,STAB1,TACR1,TACR3,TAPBP,TIMP1,TLR1,TLR2,TLR3,TNFAIP6,TNFRSF1B,TNFRSF9,TNFSF10,TNFSF15,TNFSF9,TPBG,VIP" MEMBERS_EZID="10006,10125,10135,10148,10203,10242,1026,10316,10507,10630,10663,10886,11047,114548,1236,1240,131566,1316,1317,1318,133,136,1435,1440,1441,1536,1604,166929,1839,187,1880,19,1902,1906,196,2014,2015,2069,2152,23095,23166,23308,23533,2357,23601,2550,255488,2643,27032,27074,2719,2769,2773,2811,2867,29933,3037,3091,3249,3269,3383,3386,3454,3460,3552,3553,3554,3560,3566,3569,3575,3576,3586,3587,3593,3600,3601,3604,3606,3624,3627,3656,3659,366,3665,3678,3690,3696,3732,3738,3759,391,3932,3937,3949,3976,4049,4061,4067,4084,4210,4224,4233,4283,4323,4481,4609,4693,4790,4792,488,4891,490,4973,4986,5008,5025,5027,5029,5054,5099,5142,5329,558,55829,5610,5663,5724,5732,5734,5739,5791,5817,5894,5970,5996,6004,60675,6098,623,6324,6347,6352,6354,6361,6364,6367,6369,6372,6373,6376,6401,6402,64108,64127,6504,6506,6541,6542,6717,684,6869,6870,6892,7076,7096,7097,7098,7130,7133,7162,719,728,7432,7439,7832,7855,8519,8578,8671,8685,8743,8744,8767,8807,8809,8877,9034,91,9111,9153,9180,92,929,9435,958,962,969,970,9966" MEMBERS_MAPPING="ABCA1,ABCA1,19|ABI1,ABI1,10006|ACVR1B,ACVR1B,91|ACVR2A,ACVR2A,92|ADM,ADM,133|ADORA2B,ADORA2B,136|ADRM1,ADRM1,11047|AHR,AHR,196|APLNR,APLNR,187|AQP9,AQP9,366|ATP2A2,ATP2A2,488|ATP2B1,ATP2B1,490|ATP2C1,ATP2C1,27032|AXL,AXL,558|BDKRB1,BDKRB1,623|BEST1,BEST1,7439|BST2,BST2,684|BTG2,BTG2,7832|C3AR1,C3AR1,719|C5AR1,C5AR1,728|CALCRL,CALCRL,10203|CCL17,CCL17,6361|CCL2,CCL2,6347|CCL20,CCL20,6364|CCL22,CCL22,6367|CCL24,CCL24,6369|CCL5,CCL5,6352|CCL7,CCL7,6354|CCR7,CCR7,1236|CCRL2,CCRL2,9034|CD14,CD14,929|CD40,CD40,958|CD48,CD48,962|CD55,CD55,1604|CD69,CD69,969|CD70,CD70,970|CD82,CD82,3732|CDKN1A,CDKN1A,1026|CHST2,CHST2,9435|CLEC5A,CLEC5A,23601|CMKLR1,CMKLR1,1240|CSF1,CSF1,1435|CSF3,CSF3,1440|CSF3R,CSF3R,1441|CX3CL1,CX3CL1,6376|CXCL10,CXCL10,3627|CXCL11,CXCL11,6373|CXCL6,CXCL6,6372|CXCL9,CXCL9,4283|CXCR6,CXCR6,10663|CYBB,CYBB,1536|DCBLD2,DCBLD2,131566|EBI3,EBI3,10148|EDN1,EDN1,1906|EIF2AK2,EIF2AK2,5610|EMP3,EMP3,2014|EMR1,ADGRE1,2015|EREG,EREG,2069|F3,F3,2152|FFAR2,FFAR2,2867|FPR1,FPR1,2357|FZD5,FZD5,7855|GABBR1,GABBR1,2550|GCH1,GCH1,2643|GNA15,GNA15,2769|GNAI3,GNAI3,2773|GP1BA,GP1BA,2811|GPC3,GPC3,2719|GPR132,GPR132,29933|GPR183,GPR183,1880|HAS2,HAS2,3037|HBEGF,HBEGF,1839|HIF1A,HIF1A,3091|HPN,HPN,3249|HRH1,HRH1,3269|ICAM1,ICAM1,3383|ICAM4,ICAM4,3386|ICOSLG,ICOSLG,23308|IFITM1,IFITM1,8519|IFNAR1,IFNAR1,3454|IFNGR2,IFNGR2,3460|IL10,IL10,3586|IL10RA,IL10RA,3587|IL12B,IL12B,3593|IL15,IL15,3600|IL15RA,IL15RA,3601|IL18,IL18,3606|IL18R1,IL18R1,8809|IL18RAP,IL18RAP,8807|IL1A,IL1A,3552|IL1B,IL1B,3553|IL1R1,IL1R1,3554|IL2RB,IL2RB,3560|IL4R,IL4R,3566|IL6,IL6,3569|IL7R,IL7R,3575|IL8,CXCL8,3576|INHBA,INHBA,3624|IRAK2,IRAK2,3656|IRF1,IRF1,3659|IRF7,IRF7,3665|ITGA5,ITGA5,3678|ITGB3,ITGB3,3690|ITGB8,ITGB8,3696|KCNA3,KCNA3,3738|KCNJ2,KCNJ2,3759|KCNMB2,KCNMB2,10242|KIF1B,KIF1B,23095|KLF6,KLF6,1316|LAMP3,LAMP3,27074|LCK,LCK,3932|LCP2,LCP2,3937|LDLR,LDLR,3949|LIF,LIF,3976|LPAR1,LPAR1,1902|LTA,LTA,4049|LY6E,LY6E,4061|LYN,LYN,4067|MARCO,MARCO,8685|MEFV,MEFV,4210|MEP1A,MEP1A,4224|MET,MET,4233|MMP14,MMP14,4323|MSR1,MSR1,4481|MXD1,MXD1,4084|MYC,MYC,4609|NAMPT,NAMPT,10135|NDP,NDP,4693|NFKB1,NFKB1,4790|NFKBIA,NFKBIA,4792|NLRP3,NLRP3,114548|NMI,NMI,9111|NMUR1,NMUR1,10316|NOD2,NOD2,64127|NPFFR2,NPFFR2,10886|OLR1,OLR1,4973|OPRK1,OPRK1,4986|OSM,OSM,5008|OSMR,OSMR,9180|P2RX4,P2RX4,5025|P2RX7,P2RX7,5027|P2RY2,P2RY2,5029|PCDH7,PCDH7,5099|PDE4B,PDE4B,5142|PDPN,PDPN,10630|PIK3R5,PIK3R5,23533|PLAUR,PLAUR,5329|PROK2,PROK2,60675|PSEN1,PSEN1,5663|PTAFR,PTAFR,5724|PTGER2,PTGER2,5732|PTGER4,PTGER4,5734|PTGIR,PTGIR,5739|PTPRE,PTPRE,5791|PVR,PVR,5817|RAF1,RAF1,5894|RASGRP1,RASGRP1,10125|RELA,RELA,5970|RGS1,RGS1,5996|RGS16,RGS16,6004|RHOG,RHOG,391|RIPK2,RIPK2,8767|RNF144B,RNF144B,255488|ROS1,ROS1,6098|RTP4,RTP4,64108|SCARF1,SCARF1,8578|SCN1B,SCN1B,6324|SELE,SELE,6401|SELL,SELL,6402|SELS,SELENOS,55829|SEMA4D,SEMA4D,10507|SERPINE1,SERPINE1,5054|SGMS2,SGMS2,166929|SLAMF1,SLAMF1,6504|SLC11A2,SLC11A2,4891|SLC1A2,SLC1A2,6506|SLC28A2,SLC28A2,9153|SLC31A1,SLC31A1,1317|SLC31A2,SLC31A2,1318|SLC4A4,SLC4A4,8671|SLC7A1,SLC7A1,6541|SLC7A2,SLC7A2,6542|SPHK1,SPHK1,8877|SRI,SRI,6717|STAB1,STAB1,23166|TACR1,TACR1,6869|TACR3,TACR3,6870|TAPBP,TAPBP,6892|TIMP1,TIMP1,7076|TLR1,TLR1,7096|TLR2,TLR2,7097|TLR3,TLR3,7098|TNFAIP6,TNFAIP6,7130|TNFRSF1B,TNFRSF1B,7133|TNFRSF9,TNFRSF9,3604|TNFSF10,TNFSF10,8743|TNFSF15,TNFSF15,9966|TNFSF9,TNFSF9,8744|TPBG,TPBG,7162|VIP,VIP,7432" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="RECEPTOR_ACTIVITY;M10157|MODULE_92;M10197|GOMF_G_PROTEIN_COUPLED_SEROTONIN_RECEPTOR_ACTIVITY;M10342|MODULE_274;M10420|GOBP_BEHAVIOR;M10444|GOBP_INFLAMMATORY_RESPONSE;M10617|CELLULAR_CATION_HOMEOSTASIS;M10859|MODULE_64;M10899|REGULATION_OF_BIOLOGICAL_QUALITY;M10930|KOINUMA_COLON_CANCER_MSI_UP;M1096|REACTOME_P2Y_RECEPTORS;M10960|GOMF_GROWTH_FACTOR_ACTIVITY;M11386|PLASMA_MEMBRANE_PART;M11858|GOBP_CELL_CELL_SIGNALING;M11874|GOBP_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY;M12190|REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS;M12289|GOBP_CAMP_MEDIATED_SIGNALING;M1237|MODULE_75;M12401|MODULE_289;M12584|INTRINSIC_TO_MEMBRANE;M12747|INTEGRAL_TO_MEMBRANE;M12773|DIERICK_SEROTONIN_FUNCTION_GENES;M1290|RHODOPSIN_LIKE_RECEPTOR_ACTIVITY;M13297|KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION;M13380|SHIN_B_CELL_LYMPHOMA_CLUSTER_1;M1383|GOMF_CHEMOKINE_ACTIVITY;M14051|KEGG_OLFACTORY_TRANSDUCTION;M14091|GOMF_PEPTIDE_RECEPTOR_ACTIVITY;M14461|GOMF_CYTOKINE_ACTIVITY;M14581|GOBP_SENSORY_PERCEPTION;M14699|GOBP_MONOATOMIC_ION_HOMEOSTASIS;M14716|GOMF_G_PROTEIN_COUPLED_RECEPTOR_BINDING;M14760|GOBP_SECOND_MESSENGER_MEDIATED_SIGNALING;M14872|RESPONSE_TO_STRESS;M14874|GOBP_CELLULAR_DEFENSE_RESPONSE;M15168|GOBP_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY;M15400|GOMF_SIGNALING_RECEPTOR_BINDING;M15583|chr1q44;M15976|MODULE_46;M15983|CELL_PROLIFERATION_GO_0008283;M16210|RESPONSE_TO_CHEMICAL_STIMULUS;M1649|MODULE_223;M1653|chr4q21;M16904|MODULE_76;M17322|GOBP_HOMEOSTATIC_PROCESS;M17351|GOBP_FEEDING_BEHAVIOR;M17480|GOBP_CHEMICAL_HOMEOSTASIS;M17520|GOBP_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY;M1768|WORSCHECH_TUMOR_REJECTION_UP;M1787|MODULE_367;M18076|MODULE_121;M18183|GOMF_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY;M18316|REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS;M18334|REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS;M18437|GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY;M18510|MODULE_521;M18720|YOSHIMURA_MAPK8_TARGETS_UP;M1884|GOMF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY;M18960|GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY;M19267|MODULE_488;M19433|GOBP_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING;M19701|MODULE_375;M19754|KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS;M1985|KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS_AND_CYCLIC_RGD;M1986|WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_UP;M1989|GOBP_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY;M2198|GOBP_POSITIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION;M2227|GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY;M2280|MEMBRANE_PART;M2598|RESPONSE_TO_EXTERNAL_STIMULUS;M2710|ROETH_TERT_TARGETS_DN;M2891|SYNAPTIC_TRANSMISSION;M2923|INTEGRAL_TO_PLASMA_MEMBRANE;M307|GOBP_DEFENSE_RESPONSE;M3458|MODULE_134;M3544|GOMF_PEPTIDE_BINDING;M3935|chr11q11;M3966|REACTOME_OLFACTORY_SIGNALING_PATHWAY;M4072|GOBP_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY;M419|GOMF_NEUROPEPTIDE_BINDING;M4273|GOBP_PHOSPHATIDYLINOSITOL_MEDIATED_SIGNALING;M4611|GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION;M4627|MEMBRANE;M480|KEGG_CHEMOKINE_SIGNALING_PATHWAY;M4844|MODULE_288;M491|GOMF_CHEMOKINE_RECEPTOR_BINDING;M5006|REACTOME_GPCR_LIGAND_BINDING;M507|PLASMA_MEMBRANE;M5501|GOBP_RESPONSE_TO_WOUNDING;M5634|MODULE_63;M5770|GOBP_CELLULAR_HOMEOSTASIS;M5826|REACTOME_AMINE_LIGAND_BINDING_RECEPTORS;M5868|REACTOME_G_ALPHA_I_SIGNALLING_EVENTS;M600|REACTOME_SEROTONIN_RECEPTORS;M6034|REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES;M625|AUJLA_IL22_AND_IL17A_SIGNALING;M6335|GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER;M6402|MODULE_108;M6482|GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION;M6566|REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK;M657|MODULE_146;M6672|REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS;M6786|MODULE_27;M688|MODULE_263;M7015|CATION_HOMEOSTASIS;M7087|GOBP_LOCOMOTORY_BEHAVIOR;M7204|GOMF_NEUROPEPTIDE_RECEPTOR_ACTIVITY;M726|GOBP_NEUROPEPTIDE_SIGNALING_PATHWAY;M7277|GOMF_NEUROTRANSMITTER_BINDING;M7307|REACTOME_SIGNALING_BY_GPCR;M746|SYSTEM_PROCESS;M7481|MODULE_454;M7787|CELL_SURFACE_RECEPTOR_LINKED_SIGNAL_TRANSDUCTION_GO_0007166;M7818|MODULE_433;M7888|REACTOME_GPCR_DOWNSTREAM_SIGNALING;M812|ZIRN_TRETINOIN_RESPONSE_DN;M8292|GOBP_TRANSMISSION_OF_NERVE_IMPULSE;M8461|GOCC_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE;M9232|chr11p15;M9514|GOBP_NERVOUS_SYSTEM_PROCESS;M9711" REFINEMENT_DATASETS="GSE19340,LPS vs untreated macrophages|GSE24897,P. gingivalis vs saline macrophages|GSE32141,LPS vs control THP-1 (acute myeloid leukemia)|GSE40885,LPS vs Saline 6h alveolar macrophages" VALIDATION_DATASETS="GSE32358,ATF3 KO vs WT macrophages|GSE6785,LPS vs control MH-S (macrophages)" CATEGORY_CODE="H" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE=""/>
</MSIGDB>
