STANDARD_NAME HARALAMBIEVA_PBMC_FLUARIX_AGE_50_74YO_CORR_WITH_28D_MEM_B_CELL_RESPONSE_AT_3DY_POSITIVE SYSTEMATIC_NAME M41100 COLLECTION C7:VAX MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HARALAMBIEVA_PBMC_FLUARIX_AGE_50_74YO_CORR_WITH_28D_MEM_B_CELL_RESPONSE_AT_3DY_POSITIVE NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes positively correlated with memory B cell response at 28d in peripheral blood mononuclear cell in seniors (50-74) after exposure to Fluarix , time point 3D DESCRIPTION_FULL BACKGROUND: Studies suggest that the recall-based humoral immune responses to influenza A/H1N1 originates from activated memory B cells. The aim of this study was to identify baseline, early and late blood transcriptional signatures (in peripheral blood mononuclear cells/PBMCs) associated with memory B cell response following influenza vaccination. METHODS: We used pre- and post-vaccination mRNA-Seq transcriptional profiling on samples from 159 subjects (50-74years old) following receipt of seasonal trivalent influenza vaccine containing the A/California/7/2009/H1N1-like virus, and penalized regression modeling to identify associations with influenza A/H1N1-specific memory B cell ELISPOT response after vaccination. RESULTS: Genesets and genes (p-value range 7.92E(-08) to 0.00018, q-value range 0.00019-0.039) demonstrating significant associations (of gene expression levels) with memory B cell response suggest the importance of metabolic (cholesterol and lipid metabolism-related), cell migration/adhesion, MAP kinase, NF-kB cell signaling (chemokine/cytokine signaling) and transcriptional regulation gene signatures in the development of memory B cell response after influenza vaccination. CONCLUSION: Through an unbiased transcriptome-wide profiling approach, our study identified signatures of memory B cell response following influenza vaccination, highlighting the underappreciated role of metabolic changes (among the other immune function-related events) in the regulation of influenza vaccine-induced immune memory. PMID 27317456 GEOID AUTHORS Haralambieva IH,Ovsyannikova IG,Kennedy RB,Zimmermann MT,Grill DE,Oberg AL,Poland GA CONTRIBUTOR HIPC SIGNATURES CONTRIBUTOR_ORG NIAID/HIPC SIGNATURES EXACT_SOURCE Suppl Table S1 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520794/bin/NIHMS880612-supplement-Supplemental_Information.docx SOURCE_MEMBERS ACO2,ACSL1,ADAM17,ADM,AHR,ANO8,AP3B1,AP5B1,APP,ARF1,ARL15,ARL5B,ARL8A,ARNTL2,ARSG,ASAP1,ASTL,ATP11C,ATP2A2,ATP6V0C,BCL2L2-PABPN1,BCL3,BCL6,BHLHE40,BNIP2,BOP1,BPI,C11orf51,C11orf96,C17orf103,C17orf107,C22orf13,C2orf49,C2orf69,C3orf21,C6orf145,C6orf72,C9orf140,C9orf21,C9orf89,CBWD2,CBX6,CCDC186,CCDC6,CCDC69,CCDC86,CCDC94,CCNK,CCRN4L,CDC40,CDK14,CDK8,CDKN1A,CEBPB,CERS6,CHPT1,CHRM4,CIC,CIITA,COIL,CSGALNACT2,CWC25,CXXC5,CYC1,DCTN4,DCUN1D1,DDX21,DDX3X,DHX8,DIP2B,DNAJC11,DUSP10,DYM,EAF1,EGR1,EIF2AK2,EIF3A,EIF3C,EIF4H,ELF1,EME2,EPS15L1,ETS2,ETV3,EXT1,FAF2,FAM117B,FAM175B,FAM53C,FCHSD2,FEM1A,FEM1C,FNDC3B,FOSL1,FOSL2,FOXN3,FOXO4,FRMD8P1,G0S2,GALNS,GANC,GEM,GGN,GLUD2,GMEB1,GMFB,GNA11,GNA12,GNAQ,GPM6B,GPR84,GRAMD1B,GRIK5,GRPEL1,GTF3C4,H3F3C,HBEGF,HBP1,HIC2,HIF1A,HINT3,HIST3H2A,HOXA5,HSF1,HSPA13,ICAM1,ICOSLG,ID2,ID2B,IDI2-AS1,IER2,IER3,IKBKG,IKZF5,IL1A,IL1B,IL1RAP,IL6,INCENP,INO80B,IRAK1,IRF4,IRS2,ISG20L2,ITPRIP,JARID2,JMJD1C,KAT5,KCNC3,KCNQ1,KCTD3,KDM6A,KHSRP,KIAA1958,KLF10,KLF4,KLF5,KLF7,KLHL15,KPNA2,KPNA3,KREMEN1,KRR1,KSR1,LCOR,LGALS8,LMTK2,LOC100288123,LOC642361,LRRC33,LRRC4,LRRC59,LRRK1,MAP1LC3B2,MAP2,MAP3K3,MAPK6,MAPK7,MAPK8,MAPRE1,MED13L,MED21,MED26,MEMO1,METTL14,MEX3B,MFSD14A,MICALCL,MIDN,MIER3,MKRN9P,MLX,MLXIP,MOBKL1B,MROH1,MRPS22,MTM1,MUL1,MYLIP,NAB1,NBPF10,NBPF9,NCF1C,NFIC,NFIL3,NFKBIA,NFKBID,NFKBIZ,NIPAL2,NPEPL1,NR4A3,NRIP1,NUBP1,NUDT3,OLR1,OPN3,PANK3,PCDHGC3,PDZD8,PELI1,PELI2,PER1,PFKFB3,PGAM2,PGK2,PHLDA2,PIM3,PIP5K1C,PJA2,PLEKHM2,PLEKHM3,PNO1,PNPLA2,PNPLA8,POLR2M,POM121,PPM1L,PPP1R15A,PPP1R15B,PPP1R2P3,PPP2R5E,PPP4R1L,PPP4R2,PPTC7,PRKCE,PSMB7,PTP4A1,PXK,QTRTD1,RAB11FIP2,RAB30,RAB33B,RAB5C,RAF1,RASGEF1B,REL,RGS7,RIPK2,RPL7L1,RREB1,RSRC1,RUNDC2A,S,SCML1,SEC24B,SENP2,SERINC1,SERTAD2,SFT2D2,SHANK1,SIK1,SIPA1L3,SIRT1,SKIL,SLC25A30,SLC25A34,SLC2A3,SLC38A7,SLC7A5,SLC9A7,SLK,SMARCB1,SMPD4,SMURF1,SNAI1,SNIP1,SNTB1,SNX12,SNX13,SOCS1,SOCS3,SOCS4,SPTY2D1,SRGAP2P2,SRRD,STARD4,STK17B,STRN4,STX10,SULT1B1,SYNE3,TAF13,TBC1D14,TBC1D9B,TESK2,TGFBRAP1,TMED7,TMED7-TICAM2,TMEM167B,TMEM183A,TMEM199,TMEM38A,TMEM93,TNFAIP3,TNFAIP6,TNFRSF10B,TNFRSF12A,TNFRSF13C,TNFRSF21,TOR1AIP1,TRAM1L1,TREML4,TSC22D2,TSNARE1,TWF1,TWISTNB,TXNDC5,UAP1L1,UGCG,UHRF1BP1L,USP3,USP38,USP6NL,UVRAG,UVSSA,VEGFA,VRK2,VTI1A,VTI1B,WASHC2A,WASHC2C,YPEL2,YTHDF3,ZBED4,ZBTB10,ZBTB43,ZC3H12A,ZCCHC2,ZDHHC20,ZFAT,ZFP36,ZFP91,ZFP91-CNTF,ZFP92,ZFR,ZNF124,ZNF184,ZNF281,ZNF295,ZNF304,ZNF324,ZNF487,ZNF496,ZNF511,ZNF551,ZNF614,ZNF689,ZNF791,ZNF844,ZNF93 GENE_SYMBOLS ACO2,ACSL1,ADAM17,ADM,AHR,ANO8,AP3B1,AP5B1,APP,ARF1,ARL15,ARL5B,ARL8A,BMAL2,ARSG,ASAP1,ASTL,ATP11C,ATP2A2,ATP6V0C,BCL2L2-PABPN1,BCL3,BCL6,BHLHE40,BNIP2,BOP1,BPI,ANAPC15,C11orf96,NATD1,C17orf107,GUCD1,C2orf49,C2orf69,XXYLT1,PXDC1,GINM1,SAPCD2,PRXL2C,CARD19,ZNG1B,CBX6,CCDC186,CCDC6,CCDC69,CCDC86,YJU2,CCNK,NOCT,CDC40,CDK14,CDK8,CDKN1A,CEBPB,CERS6,CHPT1,CHRM4,CIC,CIITA,COIL,CSGALNACT2,CWC25,CXXC5,CYC1,DCTN4,DCUN1D1,DDX21,DDX3X,DHX8,DIP2B,DNAJC11,DUSP10,DYM,EAF1,EGR1,EIF2AK2,EIF3A,EIF3C,EIF4H,ELF1,EME2,EPS15L1,ETS2,ETV3,EXT1,FAF2,FAM117B,ABRAXAS2,FAM53C,FCHSD2,FEM1A,FEM1C,FNDC3B,FOSL1,FOSL2,FOXN3,FOXO4,FRMD8P1,G0S2,GALNS,GANC,GEM,GGN,GLUD2,GMEB1,GMFB,GNA11,GNA12,GNAQ,GPM6B,GPR84,GRAMD1B,GRIK5,GRPEL1,GTF3C4,H3-5,HBEGF,HBP1,HIC2,HIF1A,HINT3,H2AC25,HOXA5,HSF1,HSPA13,ICAM1,ICOSLG,ID2,ID2B,IDI2-AS1,IER2,IER3,IKBKG,IKZF5,IL1A,IL1B,IL1RAP,IL6,INCENP,INO80B,IRAK1,IRF4,IRS2,ISG20L2,ITPRIP,JARID2,JMJD1C,KAT5,KCNC3,KCNQ1,KCTD3,KDM6A,KHSRP,KIAA1958,KLF10,KLF4,KLF5,KLF7,KLHL15,KPNA2,KPNA3,KREMEN1,KRR1,KSR1,LCOR,LGALS8,LMTK2,,ENSG00000272447,NRROS,LRRC4,LRRC59,LRRK1,MAP1LC3B2,MAP2,MAP3K3,MAPK6,MAPK7,MAPK8,MAPRE1,MED13L,MED21,MED26,MEMO1,METTL14,MEX3B,MFSD14A,MICAL2,MIDN,MIER3,MKRN9P,MLX,MLXIP,MOB1A,MROH1,MRPS22,MTM1,MUL1,MYLIP,NAB1,NBPF10,NBPF9,NCF1C,NFIC,NFIL3,NFKBIA,NFKBID,NFKBIZ,NIPAL2,NPEPL1,NR4A3,NRIP1,NUBP1,NUDT3,OLR1,OPN3,PANK3,PCDHGC3,PDZD8,PELI1,PELI2,PER1,PFKFB3,PGAM2,PGK2,PHLDA2,PIM3,PIP5K1C,PJA2,PLEKHM2,PLEKHM3,PNO1,PNPLA2,PNPLA8,POLR2M,POM121,PPM1L,PPP1R15A,PPP1R15B,PPP1R2B,PPP2R5E,PPP4R1L,PPP4R2,PPTC7,PRKCE,PSMB7,PTP4A1,PXK,QTRT2,RAB11FIP2,RAB30,RAB33B,RAB5C,RAF1,RASGEF1B,REL,RGS7,RIPK2,RPL7L1,RREB1,RSRC1,SNX29,,SCML1,SEC24B,SENP2,SERINC1,SERTAD2,SFT2D2,SHANK1,SIK1,SIPA1L3,SIRT1,SKIL,SLC25A30,SLC25A34,SLC2A3,SLC38A7,SLC7A5,SLC9A7,SLK,SMARCB1,SMPD4,SMURF1,SNAI1,SNIP1,SNTB1,SNX12,SNX13,SOCS1,SOCS3,SOCS4,SPTY2D1,SRGAP2B,SRRD,STARD4,STK17B,STRN4,STX10,SULT1B1,SYNE3,TAF13,TBC1D14,TBC1D9B,TESK2,TGFBRAP1,TMED7,TMED7-TICAM2,TMEM167B,TMEM183A,TMEM199,TMEM38A,EMC6,TNFAIP3,TNFAIP6,TNFRSF10B,TNFRSF12A,TNFRSF13C,TNFRSF21,TOR1AIP1,TRAM1L1,TREML4,TSC22D2,TSNARE1,TWF1,POLR1F,TXNDC5,UAP1L1,UGCG,BLTP3B,USP3,USP38,USP6NL,UVRAG,UVSSA,VEGFA,VRK2,VTI1A,VTI1B,WASHC2A,WASHC2C,YPEL2,YTHDF3,ZBED4,ZBTB10,ZBTB43,ZC3H12A,ZCCHC2,ZDHHC20,ZFAT,ZFP36,ZFP91,ZFP91-CNTF,ZFP92,ZFR,ZNF124,ZNF184,ZNF281,ZBTB21,ZNF304,ZNF324,ZNF487,ZNF496,ZNF511,ZNF551,ZNF614,ZNF689,ZNF791,ZNF844,ZNF93 FOUNDER_NAMES