STANDARD_NAME	HARALAMBIEVA_PBMC_TIV_AGE_50_74YO_CORRELATED_WITH_MEMORY_B_CELL_RESPONSE_3DY_NEGATIVE
SYSTEMATIC_NAME	M41208
COLLECTION	C7:VAX
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HARALAMBIEVA_PBMC_TIV_AGE_50_74YO_CORRELATED_WITH_MEMORY_B_CELL_RESPONSE_3DY_NEGATIVE
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes negatively correlated with memory B cell response in peripheral blood mononuclear cell in adults (50-74) after exposure to trivalent inactivated vaccine (A/California/7/09 (H1N1,), A/Perth /16/2009 (H3N2), and B/Brisbane/60/2008). , time point 3D. Comment: Association of baseline, early and late gene expression changes with peak memory B cell ELISPOT response (Day 28 - Day 0) in older individuals
DESCRIPTION_FULL	BACKGROUND: Studies suggest that the recall-based humoral immune responses to influenza A/H1N1 originates from activated memory B cells. The aim of this study was to identify baseline, early and late blood transcriptional signatures (in peripheral blood mononuclear cells/PBMCs) associated with memory B cell response following influenza vaccination. METHODS: We used pre- and post-vaccination mRNA-Seq transcriptional profiling on samples from 159 subjects (50-74years old) following receipt of seasonal trivalent influenza vaccine containing the A/California/7/2009/H1N1-like virus, and penalized regression modeling to identify associations with influenza A/H1N1-specific memory B cell ELISPOT response after vaccination. RESULTS: Genesets and genes (p-value range 7.92E(-08) to 0.00018, q-value range 0.00019-0.039) demonstrating significant associations (of gene expression levels) with memory B cell response suggest the importance of metabolic (cholesterol and lipid metabolism-related), cell migration/adhesion, MAP kinase, NF-kB cell signaling (chemokine/cytokine signaling) and transcriptional regulation gene signatures in the development of memory B cell response after influenza vaccination. CONCLUSION: Through an unbiased transcriptome-wide profiling approach, our study identified signatures of memory B cell response following influenza vaccination, highlighting the underappreciated role of metabolic changes (among the other immune function-related events) in the regulation of influenza vaccine-induced immune memory.
PMID	27317456
GEOID	
AUTHORS	Haralambieva IH,Ovsyannikova IG,Kennedy RB,Zimmermann MT,Grill DE,Oberg AL,Poland GA
CONTRIBUTOR	HIPC SIGNATURES
CONTRIBUTOR_ORG	NIAID/HIPC SIGNATURES
EXACT_SOURCE	Table 1: Early gene expression (Day 3 - Day 0)
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520794/table/T1/
SOURCE_MEMBERS	ACTL10,BLCAP,CDK4,CHMP4A,DHRS13,EEF1E1-BLOC1S5,LRP11,MAP4,PMVK,RAD51C,THAP3,TMEM99,TTLL1,ZNF233,ZNF780B
GENE_SYMBOLS	ACTL10,BLCAP,CDK4,CHMP4A,DHRS13,EEF1E1-BLOC1S5,LRP11,MAP4,PMVK,RAD51C,THAP3,KRT10-AS1,TTLL1,ZNF233,ZNF780B
FOUNDER_NAMES