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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="HARALAMBIEVA_PBMC_TIV_AGE_50_74YO_CORRELATED_WITH_MEMORY_B_CELL_RESPONSE_3DY_NEGATIVE" SYSTEMATIC_NAME="M41208" HISTORICAL_NAMES="" PMID="27317456" AUTHORS="Haralambieva IH,Ovsyannikova IG,Kennedy RB,Zimmermann MT,Grill DE,Oberg AL,Poland GA" GEOID="" EXACT_SOURCE="Table 1: Early gene expression (Day 3 - Day 0)" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520794/table/T1/" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="HIPC SIGNATURES" CONTRIBUTOR_ORG="NIAID/HIPC SIGNATURES" DESCRIPTION_BRIEF="Genes negatively correlated with memory B cell response in peripheral blood mononuclear cell in adults (50-74) after exposure to trivalent inactivated vaccine (A/California/7/09 (H1N1,), A/Perth /16/2009 (H3N2), and B/Brisbane/60/2008). , time point 3D. Comment: Association of baseline, early and late gene expression changes with peak memory B cell ELISPOT response (Day 28 - Day 0) in older individuals" DESCRIPTION_FULL="BACKGROUND: Studies suggest that the recall-based humoral immune responses to influenza A/H1N1 originates from activated memory B cells. The aim of this study was to identify baseline, early and late blood transcriptional signatures (in peripheral blood mononuclear cells/PBMCs) associated with memory B cell response following influenza vaccination. METHODS: We used pre- and post-vaccination mRNA-Seq transcriptional profiling on samples from 159 subjects (50-74years old) following receipt of seasonal trivalent influenza vaccine containing the A/California/7/2009/H1N1-like virus, and penalized regression modeling to identify associations with influenza A/H1N1-specific memory B cell ELISPOT response after vaccination. RESULTS: Genesets and genes (p-value range 7.92E(-08) to 0.00018, q-value range 0.00019-0.039) demonstrating significant associations (of gene expression levels) with memory B cell response suggest the importance of metabolic (cholesterol and lipid metabolism-related), cell migration/adhesion, MAP kinase, NF-kB cell signaling (chemokine/cytokine signaling) and transcriptional regulation gene signatures in the development of memory B cell response after influenza vaccination. CONCLUSION: Through an unbiased transcriptome-wide profiling approach, our study identified signatures of memory B cell response following influenza vaccination, highlighting the underappreciated role of metabolic changes (among the other immune function-related events) in the regulation of influenza vaccine-induced immune memory." TAGS="" MEMBERS="ACTL10,BLCAP,CDK4,CHMP4A,DHRS13,EEF1E1-BLOC1S5,LRP11,MAP4,PMVK,RAD51C,THAP3,TMEM99,TTLL1,ZNF233,ZNF780B" MEMBERS_SYMBOLIZED="ACTL10,BLCAP,CDK4,CHMP4A,DHRS13,EEF1E1-BLOC1S5,KRT10-AS1,LRP11,MAP4,PMVK,RAD51C,THAP3,TTLL1,ZNF233,ZNF780B" MEMBERS_EZID="100526837,1019,10654,10904,147015,147184,163131,170487,25809,29082,353355,4134,5889,84918,90326" MEMBERS_MAPPING="ACTL10,ACTL10,170487|BLCAP,BLCAP,10904|CDK4,CDK4,1019|CHMP4A,CHMP4A,29082|DHRS13,DHRS13,147015|EEF1E1-BLOC1S5,EEF1E1-BLOC1S5,100526837|LRP11,LRP11,84918|MAP4,MAP4,4134|PMVK,PMVK,10654|RAD51C,RAD51C,5889|THAP3,THAP3,90326|TMEM99,KRT10-AS1,147184|TTLL1,TTLL1,25809|ZNF233,ZNF233,353355|ZNF780B,ZNF780B,163131" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="VAX"/>
</MSIGDB>
