STANDARD_NAME	HASINA_NOL7_TARGETS_DN
SYSTEMATIC_NAME	M596
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HASINA_NOL7_TARGETS_DN
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Genes down-regulated in SiHa cells (cervical carcinoma) by stable expression of NOL7 [GeneID=51406] off a plasmid vector.
DESCRIPTION_FULL	Cervical cancer is associated with human papilloma virus infection. However, this infection is insufficient to induce transformation and progression. Loss of heterozygosity analyses suggest the presence of a tumor suppressor gene (TSG) on chromosome 6p21.3-p25. Here we report the cloning NOL7, its mapping to chromosome band 6p23, and localization of the protein to the nucleolus. Fluorescence in situ hybridization analysis demonstrated an allelic loss of an NOL7 in cultured tumor cells and human tumor samples. Transfection of NOL7 into cervical carcinoma cells inhibited their growth in mouse xenografts, confirming its in vivo tumor suppressor activity. The induction of tumor dormancy correlated with an angiogenic switch caused by a decreased production of vascular endothelial growth factor and an increase in the production of the angiogenesis inhibitor thrombospondin-1. These data suggest that NOL7 may function as a TSG in part by modulating the expression of the angiogenic phenotype.
PMID	16205646
GEOID	
AUTHORS	Hasina R,Pontier AL,Fekete MJ,Martin LE,Qi XM,Brigaudeau C,Pramanik R,Cline EI,Coignet LJ,Lingen MW
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	D13628,J02958,J04621,J05392,L11695,M27281,M31516,M37033,U10117,U73936,U76764,U83508,U97018,X00588
GENE_SYMBOLS	ANGPT1,MET,SDC2,SDC1,TGFBR1,VEGFA,CD55,CD53,AIMP1,JAG1,ADGRE5,ANGPT1,EML1,EGFR
FOUNDER_NAMES