STANDARD_NAME HEIDENBLAD_AMPLICON_12P11_12_DN SYSTEMATIC_NAME M1602 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HEIDENBLAD_AMPLICON_12P11_12_DN NAMESPACE Human_Image_Clone_ID DESCRIPTION_BRIEF Down-regulated genes whose expression is associated with amplification of the 12p11-12 chromosome in pancreatic cancer cell lines. DESCRIPTION_FULL DNA copy number alterations are believed to play a major role in the development and progression of human neoplasms. Although most of these genomic imbalances have been associated with dysregulation of individual genes, their large-scale transcriptional consequences remain unclear. Pancreatic carcinomas frequently display gene copy number variation of entire chromosomes as well as of chromosomal subregions. These changes range from homozygous deletions to high-level amplifications and are believed to constitute key genetic alterations in the cellular transformation of this tumor type. To investigate the transcriptional consequences of the most drastic genomic changes, that is, genomic amplifications, and to analyse the genome-wide transcriptional effects of DNA copy number changes, we performed expression profiling of 29 pancreatic carcinoma cell lines and compared the results with matching genomic profiling data. We show that a strong association between DNA copy numbers and mRNA expression levels is present in pancreatic cancer, and demonstrate that as much as 60% of the genes within highly amplified genomic regions display associated overexpression. Consequently, we identified 67 recurrently overexpressed genes located in seven precisely mapped commonly amplified regions. The presented findings indicate that more than one putative target gene may be of importance in most pancreatic cancer amplicons. PMID 15688027 GEOID AUTHORS Heidenblad M,Lindgren D,Veltman JA,Jonson T,Mahlamäki EH,Gorunova L,van Kessel AG,Schoenmakers EF,Höglund M CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Fig 4B: green in the first 4 samples FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS IMAGE:1055460,IMAGE:1520448,IMAGE:1570427,IMAGE:1572723,IMAGE:1591154,IMAGE:1635032,IMAGE:1636837,IMAGE:1896335,IMAGE:1908389,IMAGE:195836,IMAGE:2435159,IMAGE:250328,IMAGE:2509911,IMAGE:269788,IMAGE:275653,IMAGE:309864,IMAGE:322511,IMAGE:328342,IMAGE:377279,IMAGE:435055,IMAGE:447700,IMAGE:452483,IMAGE:470232,IMAGE:505538,IMAGE:563598,IMAGE:586685,IMAGE:713031,IMAGE:753080,IMAGE:814443,IMAGE:824511,IMAGE:824937,IMAGE:897529 GENE_SYMBOLS PANK1,ZNF561,C1orf116,TEKT4P2,SAR1A,GAR1,INO80,,,SDHAP4,VILL,ZBED4,SYNGR2,TRAPPC2B,,JUNB,TMEM30B,FBXL20,,,,,SNHG15,TNFRSF8,GABRP,LGALS4,SNHG1,MTURN,NOA1,ZBTB14,CDK13,ACSF2 FOUNDER_NAMES