STANDARD_NAME HINATA_NFKB_TARGETS_FIBROBLAST_UP SYSTEMATIC_NAME M4151 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HINATA_NFKB_TARGETS_FIBROBLAST_UP NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF Genes up-regulated in primary fibroblast cells by expression of p50 (NFKB1) and p65 (RELA) [GeneID=4790;5970] components of NFKB. DESCRIPTION_FULL NF-kappa B regulates normal and pathological processes, including neoplasia, in a tissue-context-dependent manner. In skin, NF-kappa B is implicated in epidermal homeostasis as well as in the pathogenesis of squamous cell carcinoma; however, its function in the underlying mesenchymal dermis has been unclear. To gain insight into NF-kappa B roles in these two adjacent cutaneous tissue compartments, NF-kappa B effects on expression of 12 435 genes were determined in epidermal keratinocytes and dermal fibroblasts. Although NF-kappa B induced proinflammatory and antiapoptotic genes in both settings, it exhibited divergent effects on growth regulatory genes. In keratinocytes, but not in fibroblasts, NF-kappa B induced p21(CIP1), which was sufficient to inhibit growth of both cell types. Levels of growth inhibitory factor (GIF), in contrast, were increased by NF-kappa B in both settings but inhibited growth only in keratinocytes. These findings indicate that transcription factors such as NF-kappa B can program tissue-selective effects via both differential target gene induction as well as by inducing common targets that exert differing effects depending on cellular lineage. PMID 12673201 GEOID AUTHORS Hinata K,Gervin AM,Jennifer Zhang Y,Khavari PA CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1: black and red colors FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AB002364,AB007889,AB011180,AC004142,AF000993,AF010312,AF024710,AF045800,AF047432,AF079167,AF087036,AF098638,AF099935,AI743090,AJ005694,AJ131244,AJ225028,AL050253,D14012,D16431,D26512,J03764,J04101,J05008,L05072,L06237,L31951,M13194,M15330,M17017,M24283,M24736,M25753,M27968,M28225,M29870,M31166,M34064,M34175,M36821,M37825,M38690,M58460,M58603,M59465,M60974,M69043,M69199,M83221,M84424,M92357,M93311,N98607,S75881,S76638,S81914,U11791,U19523,U33838,U37547,U51334,U64197,U81234,U87460,U90313,U90548,W27118,X00588,X02317,X02761,X03212,X04430,X05231,X07834,X54489,X56134,X65778,X69550,X78338,X78686,X95282,Y00630,Y07595,Z11502,Z11697 GENE_SYMBOLS ADAMTS3,MTSS1,TBC1D12,LRRN3,KDM6A,LITAF,VEGFA,GREM1,ARF6,,MSC,RABEP1,TNFAIP8,NPAS2,SPTBN1,SEC24A,GABBR1,SEZ6L,HGFAC,HDGF,MMP14,SERPINE1,ETS1,EDN1,IRF1,MAP1B,MAPK9,ERCC1,IL1B,CXCL8,ICAM1,SELE,CCNB1,FGF2,,RAC1,PTX3,CDH2,AP2B1,CXCL3,FGF5,CD9,EXOSC9,NFKB1,TNFAIP3,GADD45A,NFKBIA,G0S2,RELB,,TNFAIP2,MT3,MRPL33,MYBL1,NFKB2,IER3,CCNH,GCH1,RELA,BIRC2,TAF15,CCL20,CXCL6,,GSTO1,BTN3A3,RPA2,EGFR,SOD1,FN1,KRT7,IL6,MMP1,SOD2,CXCL1,VIM,FGF1,ARHGDIA,ABCC1,CXCL5,RND3,SERPINB2,GTF2H4,ANXA13,CD83 FOUNDER_NAMES