STANDARD_NAME HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN SYSTEMATIC_NAME M2124 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Down-regulated genes in the cancer gene signature, representing a gene signature of cellular transformation. DESCRIPTION_FULL Transcriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptional program, many drugs used for treatment of diabetes and cardiovascular diseases inhibit transformation and tumor growth. Unexpectedly, lipid metabolism genes are important for transformation and are upregulated in cancer tissues. As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kappaB, leading to transformation. OLR1 is important for maintaining the transformed state in developmentally diverse cancer cell lines and for tumor growth, suggesting a molecular connection between cancer and atherosclerosis. We suggest that the interplay between this common transcriptional program and cell-type-specific factors gives rise to phenotypically disparate human diseases. PMID 20385360 GEOID GSE17941 AUTHORS Hirsch HA,Iliopoulos D,Joshi A,Zhang Y,Jaeger SA,Bulyk M,Tsichlis PN,Shirley Liu X,Struhl K CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3S: Downregulated FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ADI1,AIM1,ALCAM,ANKRD25,ARHGDIB,ARHGEF17,ARS2,ASF1A,ATP10D,ATP1B3,BAG1,BCLAF1,BRP44L,C10orf116,C11orf51,C14orf108,C22orf9,CALD1,CAV1,CCND3,CENPF,CHD9,COL4A6,COMMD8,COTL1,CRIM1,CXorf6,DDX46,DENR,DKK1,DLG5,DMD,DNAPTP6,DPM3,DPYSL2,DST,DSTN,EPS8,FBLN1,FLJ38984,GALNT7,GAS2L1,GBP1,GCAT,GPR125,HARS,HCAP-G,HEXIM1,HMGN3,HTRA1,IFIT5,IQWD1,ISOC2,KIAA0100,KIF4A,LASP1,MLLT11,MRPL20,MYH10,NAV2,NFIC,NPM1,NQO1,NR2F2,PARN,PCMT1,PDLIM4,PLS3,PRKACB,PTDSS1,PTMS,PTPLB,PTPRK,PTRF,RACGAP1,RAI17,RAMP1,RAP2A,RGS20,RNASEN,RUSC1,S100A,SCHIP1,SFRP1,SFRS2,SFRS6,SLCO2A1,SPARC,SPRY2,STARD7,SYNCRIP,TCEAL1,TCF4,TGFB2,THBS1,TNS3,TOB1,TPM2,TSPAN14,TTC3,UBP1,UPF38,WDR73,ZWINT GENE_SYMBOLS ADI1,CRYBG1,ALCAM,KANK2,ARHGDIB,ARHGEF17,SRRT,ASF1A,ATP10D,ATP1B3,BAG1,BCLAF1,MPC1,ADIRF,ANAPC15,AP5M1,KIAA0930,CALD1,CAV1,CCND3,CENPF,CHD9,COL4A6,COMMD8,COTL1,CRIM1,MAMLD1,DDX46,DENR,DKK1,DLG5,DMD,SPATS2L,DPM3,DPYSL2,DST,DSTN,EPS8,FBLN1,C1orf216,GALNT7,GAS2L1,GBP1,GCAT,ADGRA3,HARS1,,HEXIM1,HMGN3,HTRA1,IFIT5,DCAF6,ISOC2,BLTP2,KIF4A,LASP1,MLLT11,MRPL20,MYH10,NAV2,NFIC,NPM1,NQO1,NR2F2,PARN,PCMT1,PDLIM4,PLS3,PRKACB,PTDSS1,PTMS,HACD2,PTPRK,CAVIN1,RACGAP1,ZMIZ1,RAMP1,RAP2A,RGS20,DROSHA,RUSC1,S100A1,SCHIP1,SFRP1,SRSF2,SRSF6,SLCO2A1,SPARC,SPRY2,STARD7,SYNCRIP,TCEAL1,TCF4,TGFB2,THBS1,TNS3,TOB1,TPM2,TSPAN14,TTC3,UBP1,,WDR73,ZWINT FOUNDER_NAMES