STANDARD_NAME HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN SYSTEMATIC_NAME M10487 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN NAMESPACE AFFY_Mu11K DESCRIPTION_BRIEF Genes down-regulated during differentiation from small pre-BII to immature B lymphocyte. DESCRIPTION_FULL Gene expression profiles of five consecutive stages of mouse B cell development were generated with high-density oligonucleotide arrays from as few as 2 x 10(4) ex vivo isolated and flow-cytometrically purified cells. Between 2.8% and 6.8% of all genes change on differentiation from one cellular stage to the next by at least twofold. The entire pathway involves differential expression of 10.7% of all genes. Previously known expression patterns of 15 genes (like surrogate light chain, RAG-1/2, MHC class II, mel-14 antigen) are confirmed. The gene expression patterns of the proliferating pre-BI and large pre-BII cells on the one hand, and the resting immature and mature B cells on the other hand, are most similar to each other. Small pre-BII cells display a pattern that is transitional between these two groups. Most of the genes expressed in early precursors are involved in general processes, like protein folding or cell cycle regulation, whereas more mature precursors express genes involved in more specific molecular programs (cell surface receptors, secreted factors, and adhesion molecules, among others). Between 19 and 139 genes share a given expression pattern. Combining knowledge about gene function and expression pattern allows identification of novel candidate genes potentially involved in self-maintenance of pre-BI cells, allelic exclusion and pre-B cell receptor signaling in large pre BII cells, cell-cycle arrest of small pre-BII cells, propensity toward apoptosis or anergization in immature B cells, propensity toward cell division and activation in mature B cells, and stage-specific interactions with stromal cells in the bone marrow. PMID 11779835 GEOID AUTHORS Hoffmann R,Seidl T,Neeb M,Rolink A,Melchers F CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2S: CHGF_SMA_IMM<=4 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS aa122778_s_at,aa154528_s_at,aa186047_s_at,aa218046_s_at,AA388662_at,aa422456_s_at,aa511301_s_at,aa591235_s_at,aa690583_at,AA727724_at,af014117_at,C78257_rc_s_at,D45208_at,ET63118_at,L76741_s_at,M13805_rc_g_at,m14215_s_at,M16238_s_at,m27500_f_at,M29475_s_at,M29697_s_at,M31775_rc_at,M64796_s_at,m77003_s_at,Msa.10817.0_at,Msa.1106.0_f_at,Msa.1121.0_at,Msa.11223.0_at,Msa.1350.0_s_at,Msa.15090.0_s_at,Msa.17458.0_s_at,Msa.1799.0_s_at,Msa.19156.0_s_at,Msa.21109.0_s_at,Msa.24165.0_s_at,Msa.25013.0_s_at,Msa.257.0_g_at,Msa.2622.0_at,Msa.28899.0_s_at,Msa.2938.0_s_at,Msa.30006.0_s_at,Msa.31912.0_f_at,Msa.42608.0_f_at,Msa.6346.0_s_at,Msa.7305.0_s_at,Msa.7896.0_s_at,Msa.8112.0_s_at,Msa.8856.0_s_at,Msa.887.0_at,Msa.9718.0_s_at,S68108_s_at,u24703_s_at,U52951_s_at,u96752_at,W40747_at,w91664_rc_s_at,X58708_g_at GENE_SYMBOLS ,NUPR2,PTGR1,,,GZMM,,FGL2,RAG1,IL7R,,RAG2,RAB36,PRM1,PTPRG,,EFNB1,CDC20,,AQP4,KMT2B,,,SREBF2,GFPT1,,,SELENOP,AP4B1,,,MYH9,RAB6B,,CD151,SLC3A2,XRCC6,,SMARCA4,EZH2,PLA2G4F,CCNB1,IL6ST,,GLRX,CDKN3,ZBED3,SLC16A1,PTGR1,,GFRA1,FCGR2A,PRM1,GPAM,RELN,HLA-B,DNMT3A FOUNDER_NAMES