STANDARD_NAME HOFMANN_CELL_LYMPHOMA_UP SYSTEMATIC_NAME M10783 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HOFMANN_CELL_LYMPHOMA_UP NAMESPACE AFFY_HuGene DESCRIPTION_BRIEF Genes up-regulated in lymph nodes from patients with mantle cell lymphoma (MCL) compared to the non-malignant hyperplastic lymph nodes. DESCRIPTION_FULL An imbalance between cellular apoptosis and survival may be critical for the pathogenesis of lymphoma. Therefore, the gene expression pattern in lymph node preparations from patients with mantle cell lymphoma (MCL) was compared to the pattern in nonmalignant hyperplastic lymph nodes (HLs). Oligonucleotide microarray analysis was performed comparing 5 MCLs to 4 HLs using high-density microarrays. The expression data were analyzed using Genespring software. For confirmation, the expression of selected genes was analyzed by real-time polymerase chain reaction using the RNA extracted from 16 MCL and 12 HL samples. The focus was on 42 genes that were at least 3-fold down-regulated in MCL; in addition to the B-cell leukemia 2 (BCL2) system other apoptotic pathways were altered in MCL. The FAS-associated via death domain (FADD) gene that acts downstream of the FAS cascade as a key gene to induce apoptosis was more than 10-fold down-regulated in MCL. Furthermore, the death-associated protein 6 (DAXX) gene, the caspase 2 (CASP2) gene, and the RIPK1 domain containing adapter with death domain (RAIDD) gene, which are key genes in other proapoptotic pathways, were also decreased in the MCL samples. The suggestion is made that in addition to the known overexpression of cyclin D1, which drives entry into the cell cycle, disturbances of pathways associated with apoptosis contribute to the development of MCL. (Blood. 2001;98:787-794) PMID 11468180 GEOID AUTHORS Hofmann WK,de Vos S,Tsukasaki K,Wachsman W,Pinkus GS,Said JW,Koeffler HP CONTRIBUTOR Kevin Vogelsang CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS D49950_at,K01900_at,L16991_at,L40386_s_at,L49209_s_at,M13929_s_at,M15990_at,M20137_at,M27318_f_at,M27492_at,M28130_rna1_s_at,M28213_s_at,M60751_at,M61156_at,M91196_at,M98833_at,S66431_at,S76617_at,U10324_at,U13948_at,U15173_at,U15642_s_at,U20240_at,U31120_rna1_at,U33203_s_at,U33761_at,U35005_s_at,U37022_rna1_at,U38480_at,U44103_at,U47414_at,U48405_at,U65928_at,X02751_at,X03473_at,X06318_at,X13293_at,X17576_at,X54941_at,X54993_s_at,X55544_at,X59798_at,X59842_rna1_s_at,X61615_at,X75042_at,X82200_at,X84003_at,X85134_rna1_at,X95525_at,Y10659_at GENE_SYMBOLS IL18,,DTYMK,TFDP2,RB1,MYC,YES1,IL3,IFNA4,IL1R1,CXCL8,RAB2A,,TFAP2A,IRF8,FLI1,KDM5A,BLK,ILF3,MLLT10,BNIP2,E2F5,CEBPG,IL13,MDM2,SKP2,MAPK8,CDK4,RXRG,RAB9A,CCNG2,GPR68,COPS5,NRAS,H1-0,PRKCB,MYBL2,NCK1,CKS1B,TBP,ATF1,CCND1,PBX2,LIFR,REL,TRIM22,TAF13,RBBP5,TAF5,IL13RA1 FOUNDER_NAMES