STANDARD_NAME HOLLERN_MICROACINAR_BREAST_TUMOR_DN SYSTEMATIC_NAME M717 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HOLLERN_MICROACINAR_BREAST_TUMOR_DN NAMESPACE AFFY_Mouse430 DESCRIPTION_BRIEF Genes that have low expression in mammary tumors of microacinar histology. DESCRIPTION_FULL Human breast cancer has been characterized by extensive transcriptional heterogeneity, with dominant patterns reflected in the intrinsic subtypes. Mouse models of breast cancer also have heterogeneous transcriptomes and we noted that specific histological subtypes were associated with particular subsets. We hypothesized that unique sets of genes define each tumor histological type across mouse models of breast cancer. Using mouse models that contained both gene expression data and expert pathologist classification of tumor histology on a sample by sample basis, we predicted and validated gene expression signatures for Papillary, EMT, Microacinar and other histological subtypes. These signatures predict known histological events across murine breast cancer models and identify counterparts of mouse mammary tumor types in subtypes of human breast cancer. Importantly, the EMT, Adenomyoepithelial, and Solid signatures were predictive of clinical events in human breast cancer. In addition, a pan-cancer comparison revealed that the histological signatures were active in a variety of human cancers such as lung, oral, and esophageal squamous tumors. Finally, the differentiation status and transcriptional activity implicit within these signatures was identified. These data reveal that within tumor histology groups are unique gene expression profiles of differentiation and pathway activity that stretch well beyond the transgenic initiating events and that have clear applicability to human cancers. As a result, our work provides a predictive resource and insights into possible mechanisms that govern tumor heterogeneity. PMID 29346386 GEOID AUTHORS Hollern DP,Swiatnicki MR,Andrechek ER CONTRIBUTOR Daniel Hollern CONTRIBUTOR_ORG University of North Carolina EXACT_SOURCE File S1: Downregulated_In_Microacinar FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1415802_at,1416273_at,1416342_at,1417625_s_at,1419905_s_at,1420928_at,1422561_at,1424524_at,1424938_at,1426794_at,1427167_at,1434089_at,1438855_x_at,1439373_x_at,1449449_at,1449450_at,1449682_s_at,1452679_at GENE_SYMBOLS SLC16A1,TNFAIP2,TNC,ACKR3,HPGD,ST6GAL1,ADAMTS5,DRAM1,STEAP1,PTPRS,ARMCX4,SYNPO,TNFAIP2,WNT5B,PTGES,PTGES,TUBB2B,TUBB2B FOUNDER_NAMES