STANDARD_NAME HOWLIN_CITED1_TARGETS_1_DN SYSTEMATIC_NAME M1703 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HOWLIN_CITED1_TARGETS_1_DN NAMESPACE MOUSE_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in mammary glands from the CITED1 [GeneID=4435] knockout mice: homozygotic vs. heterozygotic animals. DESCRIPTION_FULL Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed that homozygous null mutants exhibit retarded mammary ductal growth at puberty and, in addition, dilated ductal structures with a lack of spatial restriction of the subtending branches. Analysis of CITED1 homozygous null and heterozygous null mammary gland gene expression using microarrays suggested that the mammary-specific phenotype seen in the homozygous null females is due to a disturbance in the transcription of a number of key mediators of pubertal ductal morphogenesis. These include estrogen and TGFbeta responsive genes, such as the EGFR/ErbB2 ligand, amphiregulin, whose transcription we suggest is directly or indirectly regulated by CITED1. PMID 16278680 GEOID AUTHORS Howlin J,McBryan J,Napoletano S,Lambe T,McArdle E,Shioda T,Martin F CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Supplementary Data 3: Table 1 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 3100002B05Rik,5830411E10Rik,9130011B11Rik,Abcb7,Amacr,AR,Asph,Atp1a2,Btbd1,Cap1,Cdh11,Cited1,Clca2,Cryab,D1Ertd396e,D9Bwg0185e,Epb4.1l2,Eva,Galc,Hgf,Hif1a,Ier5,Ifi202b,Ifi203,Indo,Jak1,Lin7c,Mpp5,Nr1d2,Pdgfd,Rad51ap1,Rnf14,Sc5d,Slc25a24,Syt13,Tde2,Thbs1,Trfr,Trim34,Uap1,Xlr4 GENE_SYMBOLS VPS53,NABP1,TMEM30B,AKR1B1,ABCB7,AMACR,ASPH,ATP1A2,BTBD1,CAP1,CDH11,CITED1,CLCA2,CRYAB,ANGEL2,RAB6B,EPB41L2,MPZL2,GALC,HGF,HIF1A,IER5,,IFI16,IDO1,JAK1,LIN7C,PALS1,NR1D2,PDGFD,RAD51AP1,RNF14,SC5D,SLC25A24,SYT13,SERINC1,THBS1,TFRC,TRIM34,UAP1, FOUNDER_NAMES