STANDARD_NAME	HOWLIN_CITED1_TARGETS_1_DN
SYSTEMATIC_NAME	M1703
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HOWLIN_CITED1_TARGETS_1_DN
NAMESPACE	MOUSE_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in mammary glands from the CITED1 [GeneID=4435] knockout mice: homozygotic vs. heterozygotic animals.
DESCRIPTION_FULL	Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed that homozygous null mutants exhibit retarded mammary ductal growth at puberty and, in addition, dilated ductal structures with a lack of spatial restriction of the subtending branches. Analysis of CITED1 homozygous null and heterozygous null mammary gland gene expression using microarrays suggested that the mammary-specific phenotype seen in the homozygous null females is due to a disturbance in the transcription of a number of key mediators of pubertal ductal morphogenesis. These include estrogen and TGFbeta responsive genes, such as the EGFR/ErbB2 ligand, amphiregulin, whose transcription we suggest is directly or indirectly regulated by CITED1.
PMID	16278680
GEOID	
AUTHORS	Howlin J,McBryan J,Napoletano S,Lambe T,McArdle E,Shioda T,Martin F
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Supplementary Data 3: Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	3100002B05Rik,5830411E10Rik,9130011B11Rik,Abcb7,Amacr,AR,Asph,Atp1a2,Btbd1,Cap1,Cdh11,Cited1,Clca2,Cryab,D1Ertd396e,D9Bwg0185e,Epb4.1l2,Eva,Galc,Hgf,Hif1a,Ier5,Ifi202b,Ifi203,Indo,Jak1,Lin7c,Mpp5,Nr1d2,Pdgfd,Rad51ap1,Rnf14,Sc5d,Slc25a24,Syt13,Tde2,Thbs1,Trfr,Trim34,Uap1,Xlr4
GENE_SYMBOLS	VPS53,NABP1,TMEM30B,AKR1B1,ABCB7,AMACR,ASPH,ATP1A2,BTBD1,CAP1,CDH11,CITED1,CLCA2,CRYAB,ANGEL2,RAB6B,EPB41L2,MPZL2,GALC,HGF,HIF1A,IER5,,,IDO1,JAK1,LIN7C,PALS1,NR1D2,PDGFD,RAD51AP1,RNF14,SC5D,SLC25A24,SYT13,SERINC1,THBS1,TFRC,TRIM34,UAP1,FAM9C
FOUNDER_NAMES