STANDARD_NAME	HUI_MAPK14_TARGETS_UP
SYSTEMATIC_NAME	M1289
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HUI_MAPK14_TARGETS_UP
NAMESPACE	Mouse_NCBI_Gene_ID
DESCRIPTION_BRIEF	Genes up-regulated in fetal liver (days E13.5 and E15.5) samples from embryo-specific Cre-lox knockout of MAPK14 [GeneID=1432].
DESCRIPTION_FULL	The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation. Using mice carrying conditional Mapk14 (also known as p38alpha) alleles, we investigated its function in postnatal development and tumorigenesis. When we specifically deleted Mapk14 in the mouse embryo, fetuses developed to term but died shortly after birth, probably owing to lung dysfunction. Fetal hematopoietic cells and embryonic fibroblasts deficient in p38alpha showed increased proliferation resulting from sustained activation of the c-Jun N-terminal kinase (JNK)-c-Jun pathway. Notably, in chemical-induced liver cancer development, mice with liver-specific deletion of Mapk14 showed enhanced hepatocyte proliferation and tumor development that correlated with upregulation of the JNK-c-Jun pathway. Furthermore, inactivation of JNK or c-Jun suppressed the increased proliferation of Mapk14-deficient hepatocytes and tumor cells. These results demonstrate a new mechanism whereby p38alpha negatively regulates cell proliferation by antagonizing the JNK-c-Jun pathway in multiple cell types and in liver cancer development.
PMID	17468757
GEOID	GSE7342
AUTHORS	Hui L,Bakiri L,Mairhorfer A,Schweifer N,Haslinger C,Kenner L,Komnenovic V,Scheuch H,Beug H,Wagner EF
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S: FC > 0
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	103712,103819,109245,13197,14199,16421,16476,16478,17444,18218,19122,192190,20377,20522,214230,21638,23882,26399,53606,65247,66797,67445,71434,73229
GENE_SYMBOLS	ENSG00000286190,,LRRC39,GADD45A,FHL1,ITGB7,JUN,JUND,GRAP2,DUSP8,PRNP,PKHD1L1,SFRP1,SLC23A1,PAK6,TRGV11,GADD45G,MAP2K6,ISG15,ASB1,CNTNAP2,C1QTNF4,DUSP8,
FOUNDER_NAMES