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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="HUMMEL_BURKITTS_LYMPHOMA_DN" SYSTEMATIC_NAME="M18181" HISTORICAL_NAMES="" PMID="16760442" AUTHORS="Hummel M,Bentink S,Berger H,Klapper W,Wessendorf S,Barth TF,Bernd HW,Cogliatti SB,Dierlamm J,Feller AC,Hansmann ML,Haralambieva E,Harder L,Hasenclever D,Kühn M,Lenze D,Lichter P,Martin-Subero JI,Möller P,Müller-Hermelink HK,Ott G,Parwaresch RM,Pott C,Rosenwald A,Rosolowski M,Schwaenen C,Stürzenhofecker B,Szczepanowski M,Trautmann H,Wacker HH,Spang R,Loeffler M,Trümper L,Stein H,Siebert R,Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe" GEOID="GSE4475" EXACT_SOURCE="Table 5.3.2S" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_HG_U133" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Down-regulated genes constituting the molecular signature of Burkitt 's lymphoma." DESCRIPTION_FULL="BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is unclear. We used transcriptional and genomic profiling to define Burkitt's lymphoma more precisely and to distinguish subgroups in other types of mature aggressive B-cell lymphomas. METHODS: We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A molecular signature for Burkitt's lymphoma was generated, and chromosomal abnormalities were detected with interphase fluorescence in situ hybridization and array-based comparative genomic hybridization. RESULTS: We used the molecular signature for Burkitt's lymphoma to identify 44 cases: 11 had the morphologic features of diffuse large-B-cell lymphomas, 4 were unclassifiable mature aggressive B-cell lymphomas, and 29 had a classic or atypical Burkitt's morphologic appearance. Also, five did not have a detectable IG-myc Burkitt's translocation, whereas the others contained an IG-myc fusion, mostly in simple karyotypes. Of the 176 lymphomas without the molecular signature for Burkitt's lymphoma, 155 were diffuse large-B-cell lymphomas. Of these 155 cases, 21 percent had a chromosomal breakpoint at the myc locus associated with complex chromosomal changes and an unfavorable clinical course. CONCLUSIONS: Our molecular definition of Burkitt's lymphoma clarifies and extends the spectrum of the WHO criteria for Burkitt's lymphoma. In mature aggressive B-cell lymphomas without a gene signature for Burkitt's lymphoma, chromosomal breakpoints at the myc locus were associated with an adverse clinical outcome." TAGS="" MEMBERS="200660_at,201471_s_at,201502_s_at,202295_s_at,204489_s_at,204490_s_at,204882_at,204908_s_at,205081_at,205681_at,208991_at,208992_s_at,209835_x_at,210563_x_at,211317_s_at,211675_s_at,211862_x_at,212014_x_at,212063_at,212288_at,213142_x_at,215346_at,222150_s_at,38149_at" MEMBERS_SYMBOLIZED="ARHGAP25,BCL2A1,BCL3,CD40,CD44,CFLAR,CRIP1,CTSH,FNBP1,GSAP,MDFIC,NFKBIA,S100A11,SQSTM1,STAT3" MEMBERS_EZID="1396,1512,23048,29969,4792,54103,597,602,6282,6774,8837,8878,958,960,9938" MEMBERS_MAPPING="200660_at,S100A11,6282|201471_s_at,SQSTM1,8878|201502_s_at,NFKBIA,4792|202295_s_at,CTSH,1512|204489_s_at,CD44,960|204490_s_at,CD44,960|204882_at,ARHGAP25,9938|204908_s_at,BCL3,602|205081_at,CRIP1,1396|205681_at,BCL2A1,597|208991_at,STAT3,6774|208992_s_at,STAT3,6774|209835_x_at,CD44,960|210563_x_at,CFLAR,8837|211317_s_at,CFLAR,8837|211675_s_at,MDFIC,29969|211862_x_at,CFLAR,8837|212014_x_at,CD44,960|212063_at,CD44,960|212288_at,FNBP1,23048|213142_x_at,GSAP,54103|215346_at,CD40,958|222150_s_at,GSAP,54103|38149_at,ARHGAP25,9938" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
