STANDARD_NAME	HU_ANGIOGENESIS_UP
SYSTEMATIC_NAME	M6967
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HU_ANGIOGENESIS_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Up-regulated genes that separate angiogenic from non-angiogenic non-small cell lung carcinoma (NSCLC) samples.
DESCRIPTION_FULL	Angiogenesis is regarded as essential for tumour growth. However, we have demonstrated that some other aggressive non-small-cell lung carcinomas (n-SCLC) do not have angiogenesis. In this study, using cDNA microarray analysis, we demonstrate that angiogenic and nonangiogenic tumour types can be distinguished by their gene expression profiles. Tissue samples from 42 n-SCLC patients were obtained with consent. In all, 12 tumours were nonangiogenic and 30 angiogenic. The two groups were matched by age, sex, smoking and tumour stage. Total RNAs were extracted followed by microarray hybridization and image scan procedure. Data were analysed using GeneSpring 5.1 software. A total of 62 genes were found to be able to separate angiogenic from nonangiogenic tumours. Nonangiogenic tumours have higher levels of genes concerned with mitochondrial metabolism, mRNA transcription, protein synthesis and the cell cycle. Angiogenic tumours have higher levels of genes coding for membrane vesicles, integrins, remodelling, angiogenesis and apoptosis. These results further support our first finding that nonangiogenic lung tumours are fast-growing tumours filling the alveoli in the absence of vascular remodelling. We raise the hypothesis that in nonangiogenic tumours, hypoxia leads to a higher activation of the mitochondrial respiratory chain, which allows tumour growth without triggering angiogenesis.
PMID	15592519
GEOID	
AUTHORS	Hu J,Bianchi F,Ferguson M,Cesario A,Margaritora S,Granone P,Goldstraw P,Tetlow M,Ratcliffe C,Nicholson AG,Harris A,Gatter K,Pezzella F
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 4S: Angio/non-angio > 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	42388_B,ARHE,CAMK2D,CGI-07,CLTA,COL7A1,FAH,FOS,ID,ITGB4,KIAA0322,LCAT,NAPG,NRGN,PHF15,PIK3R1,PRODH,SEMAE,SIPA1L1,STK22A,STUB1,STXBP1,TSP1
GENE_SYMBOLS	,RND3,CAMK2D,NMD3,CLTA,COL7A1,FAH,FOS,,ITGB4,HECW1,LCAT,NAPG,NRGN,JADE2,PIK3R1,PRODH,SEMA3C,SIPA1L1,TSSK1A,STUB1,STXBP1,THBS1
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