STANDARD_NAME HU_ANGIOGENESIS_UP SYSTEMATIC_NAME M6967 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HU_ANGIOGENESIS_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Up-regulated genes that separate angiogenic from non-angiogenic non-small cell lung carcinoma (NSCLC) samples. DESCRIPTION_FULL Angiogenesis is regarded as essential for tumour growth. However, we have demonstrated that some other aggressive non-small-cell lung carcinomas (n-SCLC) do not have angiogenesis. In this study, using cDNA microarray analysis, we demonstrate that angiogenic and nonangiogenic tumour types can be distinguished by their gene expression profiles. Tissue samples from 42 n-SCLC patients were obtained with consent. In all, 12 tumours were nonangiogenic and 30 angiogenic. The two groups were matched by age, sex, smoking and tumour stage. Total RNAs were extracted followed by microarray hybridization and image scan procedure. Data were analysed using GeneSpring 5.1 software. A total of 62 genes were found to be able to separate angiogenic from nonangiogenic tumours. Nonangiogenic tumours have higher levels of genes concerned with mitochondrial metabolism, mRNA transcription, protein synthesis and the cell cycle. Angiogenic tumours have higher levels of genes coding for membrane vesicles, integrins, remodelling, angiogenesis and apoptosis. These results further support our first finding that nonangiogenic lung tumours are fast-growing tumours filling the alveoli in the absence of vascular remodelling. We raise the hypothesis that in nonangiogenic tumours, hypoxia leads to a higher activation of the mitochondrial respiratory chain, which allows tumour growth without triggering angiogenesis. PMID 15592519 GEOID AUTHORS Hu J,Bianchi F,Ferguson M,Cesario A,Margaritora S,Granone P,Goldstraw P,Tetlow M,Ratcliffe C,Nicholson AG,Harris A,Gatter K,Pezzella F CONTRIBUTOR Leona Saunders CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 4S: Angio/non-angio > 1 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 42388_B,ARHE,CAMK2D,CGI-07,CLTA,COL7A1,FAH,FOS,ID,ITGB4,KIAA0322,LCAT,NAPG,NRGN,PHF15,PIK3R1,PRODH,SEMAE,SIPA1L1,STK22A,STUB1,STXBP1,TSP1 GENE_SYMBOLS ,RND3,CAMK2D,NMD3,CLTA,COL7A1,FAH,FOS,,ITGB4,HECW1,LCAT,NAPG,NRGN,JADE2,PIK3R1,PRODH,SEMA3C,SIPA1L1,TSSK1A,STUB1,STXBP1,THBS1 FOUNDER_NAMES