STANDARD_NAME INGRAM_SHH_TARGETS_DN SYSTEMATIC_NAME M1322 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/INGRAM_SHH_TARGETS_DN NAMESPACE MOUSE_SEQ_ACCESSION DESCRIPTION_BRIEF Genes down-regulated in 10T1/2 cells (multipotent mesoderma) by expression of SHH [GeneID=6469]. DESCRIPTION_FULL Aberrant regulation of signalling mechanisms that normally orchestrate embryonic development, such as the Hedgehog, Wnt and Notch pathways, is a common feature of tumorigenesis. In order to better understand the neoplastic events mediated by Hedgehog signalling, we identified over 200 genes regulated by Sonic Hedgehog in multipotent mesodermal cells. Widespread crosstalk with other developmental signalling pathways is evident, suggesting a complex network of interactions that challenges the often over-simplistic representation of these pathways as simple linear entities. Hes1, a principal effector of the Notch pathway, was found to be a target of Sonic Hedgehog in both C3H/10T1/2 mesodermal and MNS70 neural cells. Desert Hedgehog also elicited a strong Hes1 response. While Smoothened function was found necessary for upregulation of Hes1 in response to Sonic Hedgehog, the mechanism does not require gamma-secretase-mediated cleavage of Notch receptors, and appears to involve transcription factors other than RBP-Jkappa. Thus, we have defined a novel mechanism for Hes1 regulation in stem-like cells that is independent of canonical Notch signalling. PMID 17873912 GEOID AUTHORS Ingram WJ,McCue KI,Tran TH,Hallahan AR,Wainwright BJ CONTRIBUTOR Jessica Robertson CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table BS FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AF013576,AF093558,AF109314,AF141322,AF153440,AF254875,AF312033,AJ277114,AK002701,AK004552,AK005412,AK005783,AK008943,AK010084,AK013855,AK014006,AK016598,AK016798,AK018071,AK018857,AK019341,AK019761,AK020587,BC005647,D10212,D90225,K02782,L19565,L29479,M74294,NM_007633,NM_007829,NM_007950,NM_007965,NM_008604,NM_008987,NM_009050,NM_009144,NM_009242,NM_009369,NM_009525,NM_009675,NM_010302,NM_010330,NM_010590,NM_011141,NM_011338,NM_011414,NM_011519,NM_011653,NM_013492,NM_013566,NM_013834,NM_016742,NM_016764,NM_016910,NM_018782,NM_018793,NM_018820,NM_018827,NM_019389,NM_019521,NM_019776,NM_020581,NM_024283,NM_025317,NM_025736,NM_026481,U08020,U50955,U75378,X16223,X17164,X70398,X89690,X94418,Z12567 GENE_SYMBOLS ,,GLRX,CAV2,BAMBI,GPM6B,ACHE,MAGED2,C2orf68,DRAM1,EEIG2,,SFRP1,ENDOD1,MEGF10,KDM8,,SEPTIN12,LRRC17,,DIRAS2,,PGM5,BRPF1,HGF,PTN,C3,SLC1A3,PLK4,IL1RN,CCNE1,DAXX,EREG,EVL,MME,PTX3,RET,SFRP2,SPARC,TGFBI,WNT5B,AOC3,GNA12,EMB,AJUBA,POU3F1,CCL15,SLPI,SDC1,TUBA1A,CLU,ITGB7,SFRP1,CDC37,PRDX4,PPM1D,CALCRL,TYK2,SERTAD1,CRLF1,VCAN,GAS6,SND1,ANGPTL4,ECRG4,MRPL54,EMC2,TPPP3,COL1A1,,,,,NREP,,, FOUNDER_NAMES