STANDARD_NAME IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN SYSTEMATIC_NAME M6315 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN NAMESPACE AFFY_Mouse430 DESCRIPTION_BRIEF Cluster 2: genes down-regulated in lung tissue samples from mice with oncogenic form of KRAS [GeneID=3845] and inactivated PTEN [GeneID=5728]. DESCRIPTION_FULL Phosphatase and tensin homologue deleted from chromosome 10 (Pten) is expressed aberrantly in non-small cell lung cancer cells, but the role of Pten in lung neoplasia has not been fully elucidated. In this study, we used a genetic approach to inactivate Pten in the bronchial epithelium of mice. Although, by itself, Pten inactivation had no discernible effect on bronchial epithelial histology, it accelerated lung tumorigenesis initiated by oncogenic K-ras, causing more rapid lethality than that induced by oncogenic K-ras alone (8 weeks versus 24 weeks of median duration of survival, respectively). Lung tumors arose in K-ras mutant, Pten-deficient mice that rapidly obstructed bronchial lumina and replaced alveolar spaces. Relative to K-ras mutant tumors, the K-ras mutant, Pten-deficient tumors exhibited more advanced histologic severity and more prominent inflammation and vascularity. Thus, Pten inactivation cooperated with oncogenic K-ras in promoting lung tumorigenesis. PMID 18281487 GEOID AUTHORS Iwanaga K,Yang Y,Raso MG,Ma L,Hanna AE,Thilaganathan N,Moghaddam S,Evans CM,Li H,Cai WW,Sato M,Minna JD,Wu H,Creighton CJ,Demayo FJ,Wistuba II,Kurie JM CONTRIBUTOR Jessica Robertson CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3S: cluster 2 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1415812_at,1415854_at,1415855_at,1415894_at,1415923_at,1415927_at,1415972_at,1416008_at,1416114_at,1416136_at,1416156_at,1416225_at,1416246_a_at,1416295_a_at,1416301_a_at,1416325_at,1416357_a_at,1416406_at,1416432_at,1416468_at,1416564_at,1416598_at,1416625_at,1416687_at,1416714_at,1416778_at,1416779_at,1416808_at,1416855_at,1417090_at,1417129_a_at,1417133_at,1417271_a_at,1417327_at,1417394_at,1417409_at,1417429_at,1417447_at,1417500_a_at,1417568_at,1417626_at,1417753_at,1417804_at,1417839_at,1417851_at,1417872_at,1417898_a_at,1417917_at,1417963_at,1418058_at,1418059_at,1418086_at,1418090_at,1418136_at,1418170_a_at,1418187_at,1418220_at,1418293_at,1418394_a_at,1418415_at,1418480_at,1418489_a_at,1418492_at,1418511_at,1418554_at,1418582_at,1418643_at,1418664_at,1418697_at,1418726_a_at,1418754_at,1418758_a_at,1418788_at,1418826_at,1418892_at,1418912_at,1418926_at,1418990_at,1419248_at,1419256_at,1419301_at,1419356_at,1419467_at,1419468_at,1419469_at,1419470_at,1419480_at,1419584_at,1419589_at,1419619_at,1419638_at,1419639_at,1419662_at,1419663_at,1419706_a_at,1419717_at,1419759_at,1419871_at,1420287_at,1420305_at,1420371_at,1420425_at,1420444_at,1420530_at,1420597_a_at,1420780_at,1420865_at,1420902_at,1421002_at,1421042_at,1421101_a_at,1421175_at,1421337_at,1421645_at,1421805_at,1421830_at,1421836_at,1421931_at,1422248_at,1422456_at,1422465_a_at,1422524_at,1422745_at,1422773_at,1422795_at,1422960_at,1423193_at,1423203_a_at,1423303_at,1423375_at,1423382_a_at,1423420_at,1423486_at,1423519_at,1423542_at,1423919_at,1424144_at,1424161_at,1424261_at,1424377_at,1424628_a_at,1424629_at,1424792_at,1424875_at,1425357_a_at,1425474_a_at,1425498_at,1425549_at,1425722_at,1425823_at,1425851_a_at,1426226_at,1426348_at,1426470_at,1426471_at,1426624_a_at,1426811_at,1426854_a_at,1426941_at,1426952_at,1426960_a_at,1426973_at,1426992_at,1427059_at,1427070_at,1427134_at,1427272_at,1427790_at,1427791_a_at,1427793_at,1427891_at,1427912_at,1428140_at,1428251_at,1428261_at,1428322_a_at,1428323_at,1428354_at,1428362_at,1428383_a_at,1428460_at,1428536_at,1428747_at,1428809_at,1429208_at,1429262_at,1429263_at,1429336_at,1429606_at,1429750_at,1429790_at,1429800_at,1429810_at,1429827_at,1429834_a_at,1429858_at,1429868_at,1429873_at,1429894_a_at,1429895_at,1429985_at,1430035_at,1430046_at,1430293_a_at,1430323_at,1430337_at,1430642_at,1430668_a_at,1430727_at,1430733_at,1430794_at,1431031_at,1431035_at,1431098_at,1431128_at,1431146_a_at,1431280_at,1431392_at,1431461_at,1431517_at,1431594_at,1431649_at,1431675_a_at,1431707_a_at,1431715_a_at,1431730_at,1431741_a_at,1431794_at,1431807_at,1431818_at,1431839_a_at,1431847_at,1431867_a_at,1431904_at,1431942_at,1431952_at,1432017_at,1432084_at,1432117_at,1432118_at,1432119_at,1432143_a_at,1432250_at,1432301_a_at,1432384_a_at,1432495_at,1432501_at,1432507_at,1432636_at,1432718_at,1432740_at,1432747_at,1432846_at,1433164_at,1433453_a_at,1433508_at,1433585_at,1433587_at,1433608_at,1433710_at,1433751_at,1433764_at,1433836_a_at,1433959_at,1434111_at,1434192_at,1434194_at,1434316_at,1434390_at,1434446_at,1434473_at,1434957_at,1435033_at,1435149_at,1435153_at,1435193_at,1435235_at,1435261_at,1435269_at,1435304_at,1435407_at,1435553_at,1435561_at,1435657_at,1435666_at,1435687_at,1435747_at,1435809_at,1435983_at,1436005_at,1436047_at,1436051_at,1436182_at,1436247_at,1436253_at,1436267_a_at,1436268_at,1436276_at,1436322_a_at,1436544_at,1436612_at,1436654_at,1436896_at,1436914_at,1437049_at,1437534_at,1437556_at,1437653_at,1437779_at,1437855_at,1437974_a_at,1438019_at,1438062_at,1438203_at,1438279_at,1438317_a_at,1438472_at,1438683_at,1438707_at,1438836_at,1438837_at,1439058_at,1439082_at,1439796_at,1440134_at,1440165_at,1440210_at,1441785_at,1442204_at,1442269_at,1442325_at,1442344_at,1442347_at,1442360_at,1442388_at,1442437_at,1442473_at,1442548_at,1442584_at,1442702_at,1442766_at,1442790_at,1442816_at,1442886_at,1442900_at,1442901_at,1442954_at,1442995_at,1443065_at,1443104_at,1443130_at,1443191_at,1443253_at,1443274_at,1443277_at,1443298_at,1443299_at,1443314_at,1443374_at,1443375_at,1443393_at,1443483_at,1443490_at,1443557_at,1443699_at,1443703_at,1443704_at,1443917_at,1443996_at,1444121_at,1444133_at,1444239_at,1444311_at,1444323_at,1444332_at,1444354_at,1444356_at,1444418_at,1444445_at,1444451_at,1444540_at,1444573_at,1444597_at,1444618_at,1444659_at,1444699_at,1444775_at,1444855_at,1444879_at,1444903_at,1444906_at,1444942_at,1445012_at,1445030_at,1445116_at,1445117_at,1445203_at,1445205_at,1445254_at,1445263_at,1445268_at,1445343_at,1445374_at,1445469_at,1445477_at,1445496_at,1445512_at,1445573_at,1445622_at,1445634_at,1445747_at,1445767_at,1445911_at,1445944_at,1445963_at,1445993_at,1446168_at,1446298_at,1446394_at,1446412_at,1446415_at,1446752_at,1446815_at,1446845_at,1446956_at,1446968_at,1447113_at,1447192_at,1447294_at,1447406_at,1448257_at,1448323_a_at,1448401_at,1448461_a_at,1448512_at,1448699_at,1449153_at,1449553_at,1450138_a_at,1450234_at,1450445_at,1450476_at,1450510_a_at,1450526_at,1450811_at,1450863_a_at,1451472_at,1451721_a_at,1451813_at,1451983_at,1452201_at,1452235_at,1453031_at,1454156_at,1454282_at,1454304_at,1454315_at,1454343_at,1454470_at,1454514_at,1454517_at,1454565_at,1454842_a_at,1454931_at,1455070_at,1455078_at,1455123_at,1455322_at,1455885_at,1455945_at,1455973_at,1456049_at,1456071_a_at,1456097_a_at,1456119_at,1456157_at,1456168_at,1456210_at,1456220_at,1456304_at,1456339_at,1456449_at,1456450_at,1456529_at,1456623_at,1456654_at,1456680_at,1456711_at,1456794_at,1456796_at,1456812_at,1456853_at,1456879_at,1456886_at,1456894_at,1457018_at,1457033_at,1457045_at,1457209_at,1457275_at,1457277_at,1457322_at,1457815_at,1457988_at,1458113_at,1458169_at,1458616_at,1458846_at,1458928_at,1459405_at,1459596_at,1459938_at,1459950_at,1460298_at,1460350_at,1460379_at,1460435_at,1460463_at,1460484_at,1460553_at,1460593_at,1460624_at,1460725_at GENE_SYMBOLS GSN,KITLG,KITLG,ENPP2,NDN,ACTC1,MARCKS,SATB1,SPARCL1,MMP2,VCL,ADH1C,CORO1A,IL2RG,EBF1,CRISP3,MCAM,PEA15,PFKFB3,ALDH1A1,SOX7,GLIS2,SERPING1,PLOD2,IRF8,CAVIN2,CAVIN2,NID1,GAS1,RCN1,MEIS2,PMP22,ENG,CAV2,KLF4,JUN,FMO1,TCF21,TGM2,NCALD,PDE4DIP,PKD2,RASGRP2,CLDN5,CXCL13,FHL1,GZMA,CNN1,PLTP,ADGRL4,ADGRL4,PPP1R14A,PLVAP,TGFB1I1,ZCCHC14,RAMP2,FOXF2,IFIT2,ADGRE5,HOXB5,PPBP,CALCRL,GREM2,DPT,GPR182,CBFA2T3,TSPAN13,MPDZ,INMT,TNNT2,ADCY8,CYTH3,TEK,MS4A6A,RHOJ,PLXDC2,ZEB1,,RGS2,SPTBN1,FZD4,KLF7,CLEC14A,CLEC14A,GNB4,GNB4,SELL,TTC28,CD93,KRT80,EFNB2,EFNB2,OGN,OGN,AKAP12,SEMA3E,ABCB1,SIK2,,,SNTB2,PRDM1,SLC22A3,DPF1,CABP2,ASCL3,ZBTB14,ST6GALNAC3,ANGPTL2,ARHGEF2,LDB2,MYT1L,ELF4,CEMIP,,AK4,MAP7,ICOS,IRS4,NSF,NXN,ABCB6,,MYT1,CUL3,SRD5A2,PSPC1,CETN1,PAXIP1,CIR1,HNRNPF,ADRB1,CRIPT,ABHD17C,KLK7,HAUS3,CDT1,DDX27,ZNF672,RSL24D1,NDUFV3,BRCA1,RPP40,SPART,GREM1,VPS39,PRPF4B,PSEN1,,CFHR3,AMIGO1,DYRK1A,COL4A1,TBP,,YPEL3,PPP2R5B,SET,MUC15,ARHGAP18,FA2H,GPR153,XPR1,TMEM184B,SNX21,SREK1,ZBTB44,ADAM1A,,,GIMAP6,CBR3,OXCT1,SMCHD1,CCDC134,NDUFB10,GPD2,FOXK2,EIF4G2,ZSWIM8,SYN2,KCNG4,TRNAU1AP,C17orf58,,RASSF6,,TMEM87B,,,CELF6,,RICTOR,,VPS51,STPG4,,CHCT1,MAP7,,,VPS50,OTUD3,FDX2,,,GLP1R,ANKRA2,,,,ARID4B,DAAM1,CLIP1,TMEM170A,CPNE8,TMEM263,HOXA3,,,,LRRC72,GTF2I,CYTH3,LIG3,TTC6,PDZD9,,,,CCDC81,,PDILT,MFSD13B,WWOX,,HIP1,,,,,HBP1,UTP14A,PRSS59P,METTL6,,,,,,,,,,ABTB2,KLF6,TNPO1,RGMB,SCFD2,EDC3,SLC39A10,CLEC2L,DEPP1,ZMAT4,ADGRL2,ZZEF1,MAP2,CHSY1,HNRNPU,INSR,SLC16A5,CDON,ARHGEF4,PLCG1,BTBD6,SHFL,TXNL1,TMTC1,EEF1AKMT1,SCAF4,,PDZD2,ERF,STON2,MAST3,SV2B,FGF14,ANKRD34A,TTLL8,SUGP2,CTIF,MYO5A,SATB1,INTS2,,MTOR,DDN,GPAT4,,ATP10D,,GEN1,INTS9,CTDSPL2,,OR5B3,ZFHX4,IRGQ,FOXH1,MAP4,HK1,IPPK,RSF1,,,ENDOG,,WASF2,ATP13A4,,CHRNA9,,DDX50,CLCA4,CYP4A11,PTPRC,CACNG2,SHISA6,,,TBC1D24,,LRP8,,,,,,,,,,HS3ST3B1,TRA2A,,TAX1BP1,,,,,,,,,NDST3,FBXW12,PDLIM3,KATNBL1,,,,,,TCERG1,PTPRK,CD28,,,,,,GEMIN8,ARHGAP25,CCND3,,,,ITPR2,,PAPPA2,,,,,,SUGP1,GPR107,,,,,HELZ,NEK11,,,,PDZD2,GTPBP3,,,,TMED5,,,,AUH,,PPP1R14B,,,,PTPRD,CHIC2,,,,,,OPRK1,,HEBP2,,,LGALSL,,PICALM,,,,,SLC29A2,BGN,SMARCD2,THOC7,H1-9P,MRPL54,MMP12,,SERPINB6,,PHEX,CNR2,CACNA1A,TLX1,,DCLK1,EARS2,HLA-DQB1,OPRK1,IRX1,SWSAP1,MAN1B1,TMEM174,SPATS2L,,,,,,,,,B3GALNT2,EID2,DCP2,SSH2,ST18,TTC21B,AMZ1,ZNF56P,C7orf57,,CYCS,ITGB3BP,GRM5,METTL17,CCNJL,PROSER2,FBXL7,AJM1,,,,,TPM1,PAQR5,B3GNT6,CFAP91,,SNAI3,ABCD2,,CCDC174,ZNF839,MIDEAS,,ZSCAN4,GALNT13,DDHD2,SYNM,MBLAC1,,,,,,,,,IQGAP3,,,,,OSBP,HOXB4,SMG9,,TTL,FAM229B,SUSD4,YOD1,XPA FOUNDER_NAMES