STANDARD_NAME	JIANG_MELANOMA_TRM2_CD8
SYSTEMATIC_NAME	M48966
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/JIANG_MELANOMA_TRM2_CD8
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	
DESCRIPTION_FULL	Tissue-resident memory T cells (TRM) are a specialized T cell population residing in peripheral tissues. The presence and potential impact of TRM in the tumor immune microenvironment (TIME) remain to be elucidated. Here, we systematically investigated the relationship between TRM and melanoma TIME based on multiple clinical single-cell RNA-seq datasets and developed signatures indicative of TRM infiltration. TRM infiltration is associated with longer overall survival and abundance of T cells, NK cells, M1 macrophages, and memory B cells in the TIME. A 22-gene TRM derived risk score was further developed to effectively classify patients into low- and high-risk categories, distinguishing overall survival and immune activation, particularly in T cell-mediated responses. Altogether, our analysis suggests that TRM abundance is associated with melanoma TIME activation and patient survival, and the TRM-based machine learning model can potentially predict prognosis in melanoma patients.
PMID	38455971
GEOID	
AUTHORS	Jiang C,Chao CC,Li J,Ge X,Shen A,Jucaud V,Cheng C,Shen X
CONTRIBUTOR	Anthony Castanza
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Supplemental Table 1. Tissue resident memory T cells cluster-specific maker gene sets. Related to Figure 2.
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.cell.com/iscience/fulltext/S2589-0042(24)00498-X
SOURCE_MEMBERS	ALOX5AP,ANKRD37,ANXA1,APOBEC3G,ARPC5L,BHLHE40,BIRC3,BRD2,BTG1,BTG2,CBLB,CCL3,CCL3L3,CCL4,CCL4L2,CCL5,CCNH,CD44,CD69,CD74,CD8A,CITED2,CKS2,CLEC2B,CLIC1,CLK1,COTL1,CREM,CRTAM,CSRNP1,CST7,CTD-3252C9.4,CTSC,CXCR4,DNAJA1,DNAJB1,DNAJB6,DTHD1,DUSP1,DUSP2,DUSP4,FABP5,FAM46C,FASLG,FOS,FOSB,GADD45B,GBP5,GLUD1,GNG2,GZMA,GZMB,GZMH,GZMK,H3F3B,HLA-A,HLA-B,HLA-C,HLA-DMA,HLA-DPA1,HLA-DPB1,HLA-DQA1,HLA-DQB1,HLA-DRA,HLA-DRB1,HLA-DRB5,HSP90AA1,HSP90AB1,HSPA1A,HSPA1B,HSPA8,HSPH1,ICOS,ID2,IFNG,IGKC,IGKV1-5,ITM2A,JMJD6,JUN,JUND,KLF6,LAG3,LCP1,LINC00152,LSP1,LYST,MALAT1,MAP3K8,MCL1,MYADM,NAMPT,NEU1,NFKBIA,NFKBID,NFKBIZ,NKG7,NR4A1,NR4A2,NR4A3,PHLDA1,PIK3R1,PNRC1,PPP1R15A,PRNP,PTGER4,PTPN22,PTPRC,RALGAPA1,RASGEF1B,RBKS,REL,RGCC,RGS1,RGS2,RHOH,RNF19A,RSRP1,SAMSN1,SAT1,SDCBP,SELK,SERTAD1,SH2D1A,SLA,SLC2A3,SRGN,SRSF2,SRSF7,STK17B,TAGAP,TMEM2,TNF,TNFAIP3,TNFSF9,TSPYL2,TUBA1A,TUBA4A,UBB,UBC,VPS37B,XCL1,XCL2,YPEL5,ZFP36,ZFP36L1,ZNF331
GENE_SYMBOLS	ALOX5AP,ANKRD37,ANXA1,APOBEC3G,ARPC5L,BHLHE40,BIRC3,BRD2,BTG1,BTG2,CBLB,CCL3,CCL3L3,CCL4,CCL4L2,CCL5,CCNH,CD44,CD69,CD74,CD8A,CITED2,CKS2,CLEC2B,CLIC1,CLK1,COTL1,CREM,CRTAM,CSRNP1,CST7,,CTSC,CXCR4,DNAJA1,DNAJB1,DNAJB6,DTHD1,DUSP1,DUSP2,DUSP4,FABP5,TENT5C,FASLG,FOS,FOSB,GADD45B,GBP5,GLUD1,GNG2,GZMA,GZMB,GZMH,GZMK,H3-3B,HLA-A,HLA-B,HLA-C,HLA-DMA,HLA-DPA1,HLA-DPB1,HLA-DQA1,HLA-DQB1,HLA-DRA,HLA-DRB1,HLA-DRB5,HSP90AA1,HSP90AB1,HSPA1A,HSPA1B,HSPA8,HSPH1,ICOS,ID2,IFNG,IGKC,IGKV1-5,ITM2A,JMJD6,JUN,JUND,KLF6,LAG3,LCP1,CYTOR,LSP1,LYST,MALAT1,MAP3K8,MCL1,MYADM,NAMPT,NEU1,NFKBIA,NFKBID,NFKBIZ,NKG7,NR4A1,NR4A2,NR4A3,PHLDA1,PIK3R1,PNRC1,PPP1R15A,PRNP,PTGER4,PTPN22,PTPRC,RALGAPA1,RASGEF1B,RBKS,REL,RGCC,RGS1,RGS2,RHOH,RNF19A,RSRP1,SAMSN1,SAT1,SDCBP,SELENOK,SERTAD1,SH2D1A,SLA,SLC2A3,SRGN,SRSF2,SRSF7,STK17B,TAGAP,CEMIP2,TNF,TNFAIP3,TNFSF9,TSPYL2,TUBA1A,TUBA4A,UBB,UBC,VPS37B,XCL1,XCL2,YPEL5,ZFP36,ZFP36L1,ZNF331
FOUNDER_NAMES