STANDARD_NAME JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP SYSTEMATIC_NAME M1120 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP NAMESPACE MOUSE_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in brain tumors induced by retroviral delivery of PDGFB [GeneID=5155]. DESCRIPTION_FULL Retroviral tagging previously identified putative cancer-causing genes in a mouse brain tumor model where a recombinant Moloney murine leukemia virus encoding the platelet-derived growth factor B-chain (MMLV/PDGFB) was intracerebrally injected in newborn mice. In the present study, expression analysis using cDNA arrays revealed several similarities of virus-induced mouse gliomas with human brain tumors. Brain tumors with short latency contained on average 8.0 retroviral insertions and resembled human glioblastoma multiforme (GBM) whereas long-latency gliomas were of lower grade, similar to human oligodendroglioma (OD) and had 2.3 insertions per tumor. Several known and novel genes of tumor progression or cell markers were differentially expressed between OD- and GBM-like tumors. Array and quantitative real-time PCR analysis demonstrated elevated expression similar to Pdgfralpha of retrovirally tagged genes Abhd2, Ddr1, Fos, Ng2, Ppfibp1, Rad51b and Sulf2 in both glioma types compared to neonatal and adult normal brain. The retrovirally tagged genes Plekhb1, Prex1, Prkg2, Sox10 and 1200004M23Rik were upregulated in the tumors but had a different expression profile than Pdgfralpha whereas Rap1gap, Gli1, Neurl and Camk2b were downregulated in the tumors. The present study accentuates the proposed role of the retrovirally tagged genes in PDGF-driven gliomagenesis and indicates that insertional mutagenesis can promote glioma progression. PMID 15750623 GEOID AUTHORS Johansson FK,Göransson H,Westermark B CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1110020P09Rik,1200004M23Rik,1810009M01Rik,2310014H01Rik,2310016E02Rik,3110068G20Rik,9430015G10Rik,Arbp,B2m,Ccnd1,Ccnd2,Cd63,Cd9,Cdc20,Cdc2a,Cdc42se1,Cdc8,Cdk4,Cnap1,Copeb,D11Ertd759e,Dbi,Eef1a1,Epn2,Fn1,Fos,Ftl1,H2-Eb1,Hmgb2,Hmox1,Hnrpa1,Hspa14,Lgals1,Marcks,Mcam,Mcm2,Mcm3,Mki67,Mlp,Nsep1,Pbk,Pcna,Pdgfra,Plk1,pol,Ppfibp1,Ppp1r14b,Rev3l,Rps27l,Rrm2,Sdc3,Serpine2,Spp1,Stat3,Sulf2,Tagln2,Tctex1,Top2a,Tpm1,Tpm4 GENE_SYMBOLS CHST11,FRMD8,TMEM176B,PPP1R18,OST4,NIN,C1orf159,RPLP0,B2M,CCND1,CCND2,CD63,CD9,CDC20,CDK1,CDC42SE1,,CDK4,,KLF6,RNF213,DBI,EEF1A1,EPN2,FN1,FOS,FTL,HLA-DRB5,HMGB2,HMOX1,HNRNPA1L2,HSPA14,LGALS1,MARCKS,MCAM,MCM2,MCM3,MKI67,MARCKSL1,YBX1,PBK,PCNA,PDGFRA,PLK1,PPFIBP1,PPP1R14B,REV3L,RPS27L,RRM2,SDC3,SERPINE2,SPP1,STAT3,SULF2,TAGLN2,DYNLT1,TOP2A,TPM1,TPM4, FOUNDER_NAMES