STANDARD_NAME KAECH_DAY8_EFF_VS_DAY15_EFF_CD8_TCELL_DN SYSTEMATIC_NAME M3025 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KAECH_DAY8_EFF_VS_DAY15_EFF_CD8_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in effector CD8 T cells at the peak expansion phase (day 8 after LCMV-Armstrong infection) compared to effector CD8 T cells at contraction phase (day 15 after LCMV-Armstrong infection). DESCRIPTION_FULL How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after viral clearance in accordance with changes in CD8 T cell functional properties. Even though memory cell precursors were present at the peak of the immune response, these cells did not display hallmark functional traits of memory T cells. However, these cells gradually acquired the memory cell qualities of self-renewal and rapid recall to antigen suggesting the model that antigen-specific CD8 T cells progressively differentiate into memory cells following viral infection. PMID 12526810 GEOID AUTHORS Kaech SM,Hemby S,Kersh E,Ahmed R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE1000001_1577_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCC5,ABCG1,ACYP1,ADCY6,AHI1,AKAP9,ALG2,AQP9,ARID3B,ARRB1,ASGR2,AXIN1,BAD,BCL2L2,BCL6,BLK,C14orf126,C19orf48,C8orf42,C8orf85,C9orf114,CADM1,CAMK2B,CASK,CCND2,CCR1,CCR6,CD22,CD4,CD40,CDK11B,CFP,CHI3L1,CNGA1,CNOT4,CRAMP1L,CREBBP,CREG1,CTSK,CXCL13,CXCR5,CXXC5,CYP2J2,D2HGDH,DALRD3,DDX24,DGCR6,DNAJB2,DUSP6,DVL1,E2F5,EMD,ERAL1,ERCC2,EVL,FABP2,FAM101B,FCER2,FCGR2B,FCRLA,FEM1B,FOXP1,FPR1,FURIN,GADD45A,GALNT10,GATM,GGA2,GLUL,GNG12,GPR133,GPR3,HBB,HEATR7A,HHEX,HIST1H1C,HLA-DOB,HMP19,HOXC4,HOXC5,HPS1,HSD17B11,HSD17B8,HTRA2,IDUA,IGF1R,IGFBP4,IGHG1,IGJ,IGKC,IGLC7,IL13RA2,IL1B,IL6R,IL7R,INPP5A,IPO4,IRF5,JUND,KCNJ8,KIAA0930,KLF4,LAPTM5,LONP1,LSM14B,LY86,MAT2A,MAU2,MLL,MLLT10,MPHOSPH10,MPP3,MUTYH,MYL4,NECAP1,NEDD4L,NIT2,NKIRAS1,NR1D2,OVGP1,P2RX4,PABPN1,PARP8,PCCB,PCSK5,PDE4B,PER1,PIM1,PISD,PKD1,PLEKHA1,PLK2,PLXNB2,PNRC1,POLG,POMGNT1,POU2AF1,POU2F1,POU6F1,PRMT3,PRNP,PTGFR,PTK6,PTPRS,RABEPK,RABGAP1L,RALGPS2,RALY,RECQL5,REM1,RERE,RGL2,RGS10,RHD,RHOB,RIN2,RNF141,RPL14,RPL30,RPL5,RPS19,RPS25,RPS6KC1,RRM2B,SBF2,SCD,SCG5,SELL,SH2B3,SLC11A2,SLC26A2,SLC3A2,SLC7A7,SLFN12,SLPI,SMAD7,SUN2,SVIL,TAPBP,TCF4,TCF7,TFCP2,TJP1,TM2D3,TOMM34,TPST1,TSC22D1,VAMP2,VKORC1,VLDLR,WASF2,WDR74,XPC,ZBTB20,ZNF187,ZNF282,ZNF398,ZNF821,ZPBP,ZYG11B GENE_SYMBOLS ABCC5,ABCG1,ACYP1,ADCY6,AHI1,AKAP9,ALG2,AQP9,ARID3B,ARRB1,ASGR2,AXIN1,BAD,BCL2L2,BCL6,BLK,DTD2,C19orf48P,TDRP,AARD,SPOUT1,CADM1,CAMK2B,CASK,CCND2,CCR1,CCR6,CD22,CD4,CD40,CDK11B,CFP,CHI3L1,CNGA1,CNOT4,CRAMP1,CREBBP,CREG1,CTSK,CXCL13,CXCR5,CXXC5,CYP2J2,D2HGDH,DALRD3,DDX24,DGCR6,DNAJB2,DUSP6,DVL1,E2F5,EMD,ERAL1,ERCC2,EVL,FABP2,RFLNB,FCER2,FCGR2B,FCRLA,FEM1B,FOXP1,FPR1,FURIN,GADD45A,GALNT10,GATM,GGA2,GLUL,GNG12,ADGRD1,GPR3,HBB,MROH1,HHEX,H1-2,HLA-DOB,NSG2,HOXC4,HOXC5,HPS1,HSD17B11,HSD17B8,HTRA2,IDUA,IGF1R,IGFBP4,IGHG1,JCHAIN,IGKC,IGLC7,IL13RA2,IL1B,IL6R,IL7R,INPP5A,IPO4,IRF5,JUND,KCNJ8,KIAA0930,KLF4,LAPTM5,LONP1,LSM14B,LY86,MAT2A,MAU2,KMT2A,MLLT10,MPHOSPH10,MPP3,MUTYH,MYL4,NECAP1,NEDD4L,NIT2,NKIRAS1,NR1D2,OVGP1,P2RX4,PABPN1,PARP8,PCCB,PCSK5,PDE4B,PER1,PIM1,PISD,PKD1,PLEKHA1,PLK2,PLXNB2,PNRC1,POLG,POMGNT1,POU2AF1,POU2F1,POU6F1,PRMT3,PRNP,PTGFR,PTK6,PTPRS,RABEPK,RABGAP1L,RALGPS2,RALY,RECQL5,REM1,RERE,RGL2,RGS10,RHD,RHOB,RIN2,RNF141,RPL14,RPL30,RPL5,RPS19,RPS25,RPS6KC1,RRM2B,SBF2,SCD,SCG5,SELL,SH2B3,SLC11A2,SLC26A2,SLC3A2,SLC7A7,SLFN12,SLPI,SMAD7,SUN2,SVIL,TAPBP,TCF4,TCF7,TFCP2,TJP1,TM2D3,TOMM34,TPST1,TSC22D1,VAMP2,VKORC1,VLDLR,WASF2,WDR74,XPC,ZBTB20,ZSCAN26,ZNF282,ZNF398,ZNF821,ZPBP,ZYG11B FOUNDER_NAMES