STANDARD_NAME KATSANOU_ELAVL1_TARGETS_DN SYSTEMATIC_NAME M2387 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KATSANOU_ELAVL1_TARGETS_DN NAMESPACE Mouse_NCBI_Gene_ID DESCRIPTION_BRIEF Genes down-regulated in MEF cells (embryonic fibroblast) with ELAVL1 [GeneID=1994] knocked out. DESCRIPTION_FULL HuR is an RNA-binding protein implicated in a diverse array of pathophysiological processes due to its effects on the posttranscriptional regulation of AU- and U-rich mRNAs. Here we reveal HuR's requirement in embryonic development through its genetic ablation. Obligatory HuR-null embryos exhibited a stage retardation phenotype and failed to survive beyond midgestation. By means of conditional transgenesis, we restricted HuR's mutation in either embryonic or endothelial compartments to demonstrate that embryonic lethality is consequent to defects in extraembryonic placenta. HuR's absence impaired the invagination of allantoic capillaries into the chorionic trophoblast layer and the differentiation of syncytiotrophoblast cells that control the morphogenesis and vascularization of the placental labyrinth and fetal support. HuR-null embryos rescued from these placental defects proceeded to subsequent developmental stages but displayed defects in skeletal ossification, fusions in limb elements, and asplenia. By coupling gene expression measurements, data meta-analysis, and HuR-RNA association assays, we identified transcription and growth factor mRNAs controlled by HuR, primarily at the posttranscriptional level, to guide morphogenesis, specification, and patterning. Collectively, our data demonstrate the dominant role of HuR in organizing gene expression programs guiding placental labyrinth morphogenesis, skeletal specification patterns, and splenic ontogeny. PMID 19307312 GEOID AUTHORS Katsanou V,Milatos S,Yiakouvaki A,Sgantzis N,Kotsoni A,Alexiou M,Harokopos V,Aidinis V,Hemberger M,Kontoyiannis DL CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3a FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 100043256,101401,106504,106522,106795,107094,107376,110695,110816,114249,11568,11735,11752,11865,12364,12505,12560,12767,12810,12833,12834,13118,13361,13612,13860,14087,14119,14165,14190,14201,14205,14238,14257,14283,14287,14313,14619,14620,14862,14941,14997,15431,15433,15951,16010,16319,16324,16574,16773,17082,17231,17427,17865,18414,18479,18584,18595,18612,18740,18788,20257,20311,20319,20393,20425,20509,207182,20913,212999,213417,21387,21453,217216,21745,217946,21810,21814,21828,21844,21853,22413,225049,225898,226518,226866,227210,230500,233908,237175,237823,237859,237988,23872,23945,24052,24059,242050,243676,243958,244810,244864,245474,26360,268930,27210,277753,320924,329278,330050,449521,50887,50915,53867,54140,544963,54613,54712,56089,56277,57349,57425,63953,66049,66425,66510,67219,67790,68058,68533,68612,70218,70358,70769,71409,71449,71566,72772,73738,74007,74351,75577,76131,76156,76294,76813,78697,78733,78785,78895,78920,83383,83814,84652,96875 GENE_SYMBOLS ,ADAMTS9,STK38,PKDCC,TCF19,RRP12,,ALDH7A1,PWP2,NPNT,AEBP1,ANK3,ANXA8L1,BMAL1,CASP12,CD44,CDH3,CXCR4,COCH,COL6A1,COL6A2,CYP4A22,DHFR,EDIL3,EPS8,FANCA,FBN2,FGF10,FGL2,FHL3,VEGFD,FOXF2,FLT4,FOSL1,FPGS,FST,GJB2,GJB3,GSTM1,GZMH,,HOXD11,HOXD13,IFI16,IGFBP4,INCENP,INHBB,KIF5C,LAMA2,IL1RL1,,MNS1,MYBL2,OSMR,PAK1,PDE8A,PDGFRA,ETV4,PITX1,SERPINB2,STMN2,CXCL6,SFRP2,SGK1,SHMT1,SLC19A1,GGT7,STXBP4,TNPO2,KLHDC8A,TBX4,TCOF1,HROB,TEP1,CDCA7L,TGFBI,TGFBR3,THBS4,TIAM1,TIMELESS,WNT2,TTC7A,EML3,NMNAT2,SBSPON,CCNYL1,EFCAB7,FUS,ADGRG2,PFAS,NSRP1,CDR2L,ETS2,MGLL,SGCD,SLCO2A1,IGSF10,,SIGLEC10,VWA5A,LAYN,DKC1,ANGPTL2,PKMYT1,SNORD34,CYP4A22,CCBE1,TNN,FAM185A,ZNF213,HMGN5,GRB14,COL5A3,AVPR1A,IQGAP2,ST3GAL6,PLXNC1,RAMP3,TMEM45A,PPBP,,DUSP10,ROGDI,PCP4L1,RNF181,MED18,RAB39B,CHD1L,MPHOSPH6,UBE2C,KIF18B,STEAP1,NOLC1,FMNL2,METTL13,CLMP,RINT1,HAUS7,ABTB3,DDX23,DYNAP,DEPDC1,FAM131B,ASB5,ARMC6,PUS7,TROAP,CLIP4,PUS7L,DLST,TFAP4,NEDD4L,HYCC1,PRG4 FOUNDER_NAMES