STANDARD_NAME	KAYO_AGING_MUSCLE_DN
SYSTEMATIC_NAME	M17261
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KAYO_AGING_MUSCLE_DN
NAMESPACE	AFFY_HuGene
DESCRIPTION_BRIEF	Downregulated in the vastus lateralis muscle of aged vs young adult rhesus monkeys
DESCRIPTION_FULL	In laboratory rodents, caloric restriction (CR) retards several age-dependent physiological and biochemical changes in skeletal muscle, including increased steady-state levels of oxidative damage to lipids, DNA, and proteins. We have previously used high-density oligonucleotide arrays to show that CR can prevent or delay most of the major age-related transcriptional alterations in the gastrocnemius muscle of C57BL/6 mice. Here we report the effects of aging and adult-onset CR on the gene expression profile of 7,070 genes in the vastus lateralis muscle from rhesus monkeys. Gene expression analysis of aged rhesus monkeys (mean age of 26 years) was compared with that of young animals (mean age of 8 years). Aging resulted in a selective up-regulation of transcripts involved in inflammation and oxidative stress, and a down-regulation of genes involved in mitochondrial electron transport and oxidative phosphorylation. Middle-aged monkeys (mean age of 20 years) subjected to CR since early adulthood (mean age of 11 years) were studied to determine the gene expression profile induced by CR. CR resulted in an up-regulation of cytoskeletal protein-encoding genes, and also a decrease in the expression of genes involved in mitochondrial bioenergetics. Surprisingly, we did not observe any evidence for an inhibitory effect of adult-onset CR on age-related changes in gene expression. These results indicate that the induction of an oxidative stress-induced transcriptional response may be a common feature of aging in skeletal muscle of rodents and primates, but the extent to which CR modifies these responses may be species-specific.
PMID	11309484
GEOID	
AUTHORS	Kayo T,Allison DB,Weindruch R,Prolla TA
CONTRIBUTOR	John Newman
CONTRIBUTOR_ORG	University of Washington
EXACT_SOURCE	Table 7S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AB006781_s_at,AF005043_at,D13435_at,D13636_at,D14710_at,D16532_at,D16562_at,D21852_at,D29958_at,D29992_at,D31628_s_at,D38037_at,D49387_at,D50663_at,D50810_at,D50920_at,D55654_at,D67029_at,D80010_at,D83783_at,D87440_at,D87461_at,HG1515-HT1515_f_at,HG3369-HT3546_at,HG4165-HT4435_at,HG4334-HT4604_s_at,HG870-HT870_at,HG987-HT987_at,J02645_at,J03040_at,J04810_s_at,J04823_rna1_at,J05272_at,J05401_at,L08666_at,L21998_at,L27560_at,L28821_at,L34587_at,L35263_at,L36720_at,L38820_at,L48513_at,M11722_at,M12963_s_at,M14504,M15661_at,M17733_at,M19267_s_at,M20681_at,M22538_at,M36430_s_at,M37104_at,M55210_at,M55683_at,M57710_at,M58525_s_at,M58603_at,M63838_s_at,M64716_at,M74089_at,M80359_at,M83652_s_at,S54005_s_at,S80343_at,U01922_at,U07806_s_at,U08023_at,U08377_at,U09813_at,U10117_at,U15009_at,U15552_at,U15655_at,U17886_at,U18291_at,U25849_at,U26591_at,U27460_at,U28014_at,U32499_s_at,U33818_at,U34252_at,U39317_at,U39817_at,U43431_at,U48251_at,U49188_at,U52427_rna1_at,U52827_at,U53225_at,U59289_at,U59309_at,U62801_at,U65092_at,U71598_at,U75308_at,U77594_at,U88629_at,U90268_at,U90304_at,U90549_at,U90904_at,U95740_rna1_at,X00588_at,X04803,X15341_at,X15940_at,X16832_at,X51630_at,X57985_rna2_at,X59417_at,X60708_at,X61755_rna1_s_at,X65965_s_at,X69150_at,X76013_at,X76057_at,X76059_at,X77737_at,X78687_at,X80692_at,X84195_at,X85133_at,X89416_at,X96752_at,Y00764_at,Y10141_s_at,Z25749_rna1_at,Z27113_at,Z35093_at,Z69030_s_at
GENE_SYMBOLS	LGALS4,PARG,PIGF,GTF3C2,ATP5F1A,VLDLR,ATP5F1C,R3HDM1,EXOSC7,TFPI2,HPD,FKBP1B,PTGR1,DYNLT1,LNPEP,MED24,MDH1,SEC14L1,LPIN1,MED12,RTF1,BCL2L2,,,,,,,EIF2S1,SPARC,MSH3,COX8A,IMPDH1,CKMT2,VDAC2,MUC2,IGFBP5,MAN2A2,ELOC,MAPK14,BYSL,CD1D,PON2,DNTT,ADH1A,PSKH1,RPL36AL,TMSB4X,TPM1,SLC2A3,NDUFV2,,ATP5PF,LAMC1,MATN1,LGALS3,COMT,NFKB1,IFI16,RPS25,SLC25A46,MARK3,CFP,TMSB10,RARS1,,TOP1,MERTK,SFSWAP,ATP5MC3,AIMP1,SNRPD3,DNTTIP2,ERF,SDHB,CDC16,ACP1,ICA1,UGP2,CASP4,DRD3,PABPC4,ALDH9A1,UBE2D2,BLM,TOP3A,ZMYND8,SERINC3,POLR2G,MARCHF6,SNX1,CDH13,FH,KLK6,CITED1,ZNF274,TAF4,RARRES2,ELL2,KRIT1,IRX5,HMGN4,,MARF1,EGFR,UBB,COX6A1,RPL31,CTSH,WT1,H2BC21,PSMA6,DPP4,HOXC5,SOD2,RPS18,QARS1,MPI,RBMY1A1,SLC4A1,NEU1,MAPK6,,RBBP6,PPP5C,HADH,UQCRH,SLC6A3,RPS7,POLR2F,SURF1,PPP2R5C
FOUNDER_NAMES