STANDARD_NAME KAYO_AGING_MUSCLE_DN SYSTEMATIC_NAME M17261 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KAYO_AGING_MUSCLE_DN NAMESPACE AFFY_HuGene DESCRIPTION_BRIEF Downregulated in the vastus lateralis muscle of aged vs young adult rhesus monkeys DESCRIPTION_FULL In laboratory rodents, caloric restriction (CR) retards several age-dependent physiological and biochemical changes in skeletal muscle, including increased steady-state levels of oxidative damage to lipids, DNA, and proteins. We have previously used high-density oligonucleotide arrays to show that CR can prevent or delay most of the major age-related transcriptional alterations in the gastrocnemius muscle of C57BL/6 mice. Here we report the effects of aging and adult-onset CR on the gene expression profile of 7,070 genes in the vastus lateralis muscle from rhesus monkeys. Gene expression analysis of aged rhesus monkeys (mean age of 26 years) was compared with that of young animals (mean age of 8 years). Aging resulted in a selective up-regulation of transcripts involved in inflammation and oxidative stress, and a down-regulation of genes involved in mitochondrial electron transport and oxidative phosphorylation. Middle-aged monkeys (mean age of 20 years) subjected to CR since early adulthood (mean age of 11 years) were studied to determine the gene expression profile induced by CR. CR resulted in an up-regulation of cytoskeletal protein-encoding genes, and also a decrease in the expression of genes involved in mitochondrial bioenergetics. Surprisingly, we did not observe any evidence for an inhibitory effect of adult-onset CR on age-related changes in gene expression. These results indicate that the induction of an oxidative stress-induced transcriptional response may be a common feature of aging in skeletal muscle of rodents and primates, but the extent to which CR modifies these responses may be species-specific. PMID 11309484 GEOID AUTHORS Kayo T,Allison DB,Weindruch R,Prolla TA CONTRIBUTOR John Newman CONTRIBUTOR_ORG University of Washington EXACT_SOURCE Table 7S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AB006781_s_at,AF005043_at,D13435_at,D13636_at,D14710_at,D16532_at,D16562_at,D21852_at,D29958_at,D29992_at,D31628_s_at,D38037_at,D49387_at,D50663_at,D50810_at,D50920_at,D55654_at,D67029_at,D80010_at,D83783_at,D87440_at,D87461_at,HG1515-HT1515_f_at,HG3369-HT3546_at,HG4165-HT4435_at,HG4334-HT4604_s_at,HG870-HT870_at,HG987-HT987_at,J02645_at,J03040_at,J04810_s_at,J04823_rna1_at,J05272_at,J05401_at,L08666_at,L21998_at,L27560_at,L28821_at,L34587_at,L35263_at,L36720_at,L38820_at,L48513_at,M11722_at,M12963_s_at,M14504,M15661_at,M17733_at,M19267_s_at,M20681_at,M22538_at,M36430_s_at,M37104_at,M55210_at,M55683_at,M57710_at,M58525_s_at,M58603_at,M63838_s_at,M64716_at,M74089_at,M80359_at,M83652_s_at,S54005_s_at,S80343_at,U01922_at,U07806_s_at,U08023_at,U08377_at,U09813_at,U10117_at,U15009_at,U15552_at,U15655_at,U17886_at,U18291_at,U25849_at,U26591_at,U27460_at,U28014_at,U32499_s_at,U33818_at,U34252_at,U39317_at,U39817_at,U43431_at,U48251_at,U49188_at,U52427_rna1_at,U52827_at,U53225_at,U59289_at,U59309_at,U62801_at,U65092_at,U71598_at,U75308_at,U77594_at,U88629_at,U90268_at,U90304_at,U90549_at,U90904_at,U95740_rna1_at,X00588_at,X04803,X15341_at,X15940_at,X16832_at,X51630_at,X57985_rna2_at,X59417_at,X60708_at,X61755_rna1_s_at,X65965_s_at,X69150_at,X76013_at,X76057_at,X76059_at,X77737_at,X78687_at,X80692_at,X84195_at,X85133_at,X89416_at,X96752_at,Y00764_at,Y10141_s_at,Z25749_rna1_at,Z27113_at,Z35093_at,Z69030_s_at GENE_SYMBOLS LGALS4,PARG,PIGF,GTF3C2,ATP5F1A,VLDLR,ATP5F1C,R3HDM1,EXOSC7,TFPI2,HPD,FKBP1B,PTGR1,DYNLT1,LNPEP,MED24,MDH1,SEC14L1,LPIN1,MED12,RTF1,BCL2L2,,,,,,,EIF2S1,SPARC,MSH3,COX8A,IMPDH1,CKMT2,VDAC2,MUC2,IGFBP5,MAN2A2,ELOC,MAPK14,BYSL,CD1D,PON2,DNTT,ADH1A,PSKH1,RPL36AL,TMSB4X,TPM1,SLC2A3,NDUFV2,GNB1,ATP5PF,LAMC1,MATN1,LGALS3,COMT,NFKB1,IFI16,RPS25,SLC25A46,MARK3,CFP,TMSB10,RARS1,,TOP1,MERTK,SFSWAP,ATP5MC3,AIMP1,SNRPD3,DNTTIP2,ERF,SDHB,CDC16,ACP1,ICA1,UGP2,CASP4,DRD3,PABPC4,ALDH9A1,UBE2D2,BLM,TOP3A,ZMYND8,SERINC3,POLR2G,MARCHF6,SNX1,CDH13,FH,KLK6,CITED1,ZNF274,TAF4,RARRES2,ELL2,KRIT1,IRX5,HMGN4,NIPA2,MARF1,EGFR,UBB,COX6A1,RPL31,CTSH,WT1,H2BC21,PSMA6,DPP4,HOXC5,SOD2,RPS18,QARS1,MPI,RBMY1A1,SLC4A1,NEU1,MAPK6,,RBBP6,PPP5C,HADH,UQCRH,SLC6A3,RPS7,POLR2F,SURF1,PPP2R5C FOUNDER_NAMES