STANDARD_NAME KEGG_CELL_ADHESION_MOLECULES_CAMS SYSTEMATIC_NAME M16476 COLLECTION C2:CP:KEGG_LEGACY MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_CELL_ADHESION_MOLECULES_CAMS NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF Cell adhesion molecules (CAMs) DESCRIPTION_FULL Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cellcell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. PMID GEOID AUTHORS CONTRIBUTOR KEGG CONTRIBUTOR_ORG Kyoto Encyclopedia of Genes and Genomes EXACT_SOURCE hsa04514 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL http://www.genome.jp/kegg/pathway/hsa/hsa04514.html SOURCE_MEMBERS 1000,1001,1002,1003,1013,10666,10686,1272,1364,1365,1366,137075,1462,1493,149461,214,22871,23114,23308,23562,23705,24146,257194,25945,26047,26285,2734,29126,29851,3105,3106,3107,3108,3109,3111,3112,3113,3115,3117,3118,3119,3122,3123,3125,3126,3127,3133,3134,3135,3383,3384,3385,3655,3676,3680,3683,3684,3685,3688,3689,3695,3696,3897,4099,4267,4359,4684,4685,4756,4897,4950,49861,5010,50848,51208,5133,5175,53842,54413,57502,57555,57863,5788,5792,5797,5817,5818,5819,58494,6382,6383,6385,6401,6402,6403,6404,652614,6614,6693,6900,7122,7412,80380,80381,8174,83700,8506,8516,9019,9071,9073,9074,9075,9076,9080,90952,914,920,923,925,926,933,9369,9378,9379,940,941,942,947,958,959,965,9672,999 GENE_SYMBOLS CDH2,CDH3,CDH4,CDH5,CDH15,CD226,CLDN16,CNTN1,CLDN4,CLDN3,CLDN7,CLDN23,VCAN,CTLA4,CLDN19,ALCAM,NLGN1,NFASC,ICOSLG,CLDN14,CADM1,CLDN15,NEGR1,NECTIN3,CNTNAP2,CLDN17,GLG1,CD274,ICOS,HLA-A,HLA-B,HLA-C,HLA-DMA,HLA-DMB,HLA-DOA,HLA-DOB,HLA-DPA1,HLA-DPB1,HLA-DQA1,HLA-DQA2,HLA-DQB1,HLA-DRA,HLA-DRB1,HLA-DRB3,HLA-DRB4,HLA-DRB5,HLA-E,HLA-F,HLA-G,ICAM1,ICAM2,ICAM3,ITGA6,ITGA4,ITGA9,ITGAL,ITGAM,ITGAV,ITGB1,ITGB2,ITGB7,ITGB8,L1CAM,MAG,CD99,MPZ,NCAM1,NCAM2,NEO1,NRCAM,OCLN,CLDN20,CLDN11,F11R,CLDN18,PDCD1,PECAM1,CLDN22,NLGN3,NLGN4X,NLGN2,CADM3,PTPRC,PTPRF,PTPRM,PVR,NECTIN1,NECTIN2,JAM2,SDC1,SDC2,SDC4,SELE,SELL,SELP,SELPLG,,SIGLEC1,SPN,CNTN2,CLDN5,VCAM1,PDCD1LG2,CD276,MADCAM1,JAM3,CNTNAP1,ITGA8,MPZL1,CLDN10,CLDN8,CLDN6,CLDN2,CLDN1,CLDN9,ESAM,CD2,CD4,CD6,CD8A,CD8B,CD22,NRXN3,NRXN1,NRXN2,CD28,CD80,CD86,CD34,CD40,CD40LG,CD58,SDC3,CDH1 FOUNDER_NAMES