STANDARD_NAME	KEGG_CITRATE_CYCLE_TCA_CYCLE
SYSTEMATIC_NAME	M3985
COLLECTION	C2:CP:KEGG_LEGACY
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_CITRATE_CYCLE_TCA_CYCLE
NAMESPACE	Human_NCBI_Gene_ID
DESCRIPTION_BRIEF	Citrate cycle (TCA cycle)
DESCRIPTION_FULL	The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle , but contain genes for specific segments.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	KEGG
CONTRIBUTOR_ORG	Kyoto Encyclopedia of Genes and Genomes
EXACT_SOURCE	hsa00020
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	http://www.genome.jp/pathway/hsa00020
SOURCE_MEMBERS	1431,1737,1738,1743,2271,283398,3417,3418,3419,3420,3421,4190,4191,47,48,4967,50,5091,5105,5106,5160,5161,5162,55753,6389,6390,6391,6392,642502,8801,8802,8803
GENE_SYMBOLS	CS,DLAT,DLD,DLST,FH,SUCLG2P2,IDH1,IDH2,IDH3A,IDH3B,IDH3G,MDH1,MDH2,ACLY,ACO1,OGDH,ACO2,PC,PCK1,PCK2,PDHA1,PDHA2,PDHB,OGDHL,SDHA,SDHB,SDHC,SDHD,SDHCP5,SUCLG2,SUCLG1,SUCLA2
FOUNDER_NAMES