STANDARD_NAME KEGG_COMPLEMENT_AND_COAGULATION_CASCADES SYSTEMATIC_NAME M16894 COLLECTION C2:CP:KEGG_LEGACY MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_COMPLEMENT_AND_COAGULATION_CASCADES NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF Complement and coagulation cascades DESCRIPTION_FULL Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. PMID GEOID AUTHORS CONTRIBUTOR KEGG CONTRIBUTOR_ORG Kyoto Encyclopedia of Genes and Genomes EXACT_SOURCE hsa04610 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL http://www.genome.jp/kegg/pathway/hsa/hsa04610.html SOURCE_MEMBERS 10747,1361,1378,1380,1604,1675,2,2147,2149,2152,2153,2155,2157,2158,2159,2160,2161,2162,2165,2243,2244,2266,3053,3075,3426,3818,3827,4153,4179,462,5054,5104,5265,5327,5328,5329,5340,5345,5624,5627,5648,623,624,629,7035,7056,710,712,713,714,715,716,717,718,719,720,721,722,725,727,728,729,730,731,732,733,735,7450,966 GENE_SYMBOLS MASP2,CPB2,CR1,CR2,CD55,CFD,A2M,F2,F2R,F3,F5,F7,F8,F9,F10,F11,F12,F13A1,F13B,FGA,FGB,FGG,SERPIND1,CFH,CFI,KLKB1,KNG1,MBL2,CD46,SERPINC1,SERPINE1,SERPINA5,SERPINA1,PLAT,PLAU,PLAUR,PLG,SERPINF2,PROC,PROS1,MASP1,BDKRB1,BDKRB2,CFB,TFPI,THBD,SERPING1,C1QA,C1QB,C1QC,C1R,C1S,C2,C3,C3AR1,C4A,C4B,C4BPA,C4BPB,C5,C5AR1,C6,C7,C8A,C8B,C8G,C9,VWF,CD59 FOUNDER_NAMES