STANDARD_NAME KEGG_ECM_RECEPTOR_INTERACTION SYSTEMATIC_NAME M7098 COLLECTION C2:CP:KEGG_LEGACY MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_ECM_RECEPTOR_INTERACTION NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF ECM-receptor interaction DESCRIPTION_FULL The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits. PMID GEOID AUTHORS CONTRIBUTOR KEGG CONTRIBUTOR_ORG Kyoto Encyclopedia of Genes and Genomes EXACT_SOURCE hsa04512 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL http://www.genome.jp/kegg/pathway/hsa/hsa04512.html SOURCE_MEMBERS 10319,1101,1277,1278,1280,1281,1282,1284,1286,1288,1289,1290,1291,1292,1293,1301,1302,1311,131873,1605,22798,22801,22987,2335,2811,2812,2814,2815,284217,3161,3339,3371,3381,3655,3672,3673,3674,3675,3676,3678,3679,3680,3685,3688,3690,3691,3693,3694,3695,3696,375790,3908,3909,3910,3911,3912,3913,3914,3915,3918,50509,51206,5649,6382,6383,6385,63923,6696,7057,7058,7059,7060,7143,7148,7448,7450,8515,8516,948,960,961,9672,9899,9900 GENE_SYMBOLS LAMC3,CHAD,COL1A1,COL1A2,COL2A1,COL3A1,COL4A1,COL4A2,COL4A4,COL4A6,COL5A1,COL5A2,COL6A1,COL6A2,COL6A3,COL11A1,COL11A2,COMP,COL6A6,DAG1,LAMB4,ITGA11,SV2C,FN1,GP1BA,GP1BB,GP5,GP9,LAMA1,HMMR,HSPG2,TNC,IBSP,ITGA6,ITGA1,ITGA2,ITGA2B,ITGA3,ITGA4,ITGA5,ITGA7,ITGA9,ITGAV,ITGB1,ITGB3,ITGB4,ITGB5,ITGB6,ITGB7,ITGB8,AGRN,LAMA2,LAMA3,LAMA4,LAMA5,LAMB1,LAMB2,LAMB3,LAMC1,LAMC2,COL5A3,GP6,RELN,SDC1,SDC2,SDC4,TNN,SPP1,THBS1,THBS2,THBS3,THBS4,TNR,TNXB,VTN,VWF,ITGA10,ITGA8,CD36,CD44,CD47,SDC3,SV2B,SV2A FOUNDER_NAMES