STANDARD_NAME KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY SYSTEMATIC_NAME M15569 COLLECTION C2:CP:KEGG_LEGACY MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF NOD-like receptor signaling pathway DESCRIPTION_FULL Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway. PMID GEOID AUTHORS CONTRIBUTOR KEGG CONTRIBUTOR_ORG Kyoto Encyclopedia of Genes and Genomes EXACT_SOURCE hsa04621 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL http://www.genome.jp/kegg/pathway/hsa/hsa04621.html SOURCE_MEMBERS 10392,10454,10910,114548,1147,1432,22861,22900,23118,257397,260434,29108,2919,2920,329,330,331,3320,3326,3551,3553,3569,3576,3606,4210,4671,4790,4792,4793,55914,5594,5595,5599,5600,5601,5602,5603,58484,59082,5970,6300,6347,6352,6354,6355,6356,6357,64127,64170,6885,7124,7128,7184,7189,7205,834,838,841,84674,8517,8767,9051 GENE_SYMBOLS NOD1,TAB1,SUGT1,NLRP3,CHUK,MAPK14,NLRP1,CARD8,TAB2,TAB3,PYDC1,PYCARD,CXCL1,CXCL2,BIRC2,BIRC3,XIAP,HSP90AA1,HSP90AB1,IKBKB,IL1B,IL6,CXCL8,IL18,MEFV,NAIP,NFKB1,NFKBIA,NFKBIB,ERBIN,MAPK1,MAPK3,MAPK8,MAPK11,MAPK9,MAPK10,MAPK13,NLRC4,CARD18,RELA,MAPK12,CCL2,CCL5,CCL7,CCL8,CCL11,CCL13,NOD2,CARD9,MAP3K7,TNF,TNFAIP3,HSP90B1,TRAF6,TRIP6,CASP1,CASP5,CASP8,CARD6,IKBKG,RIPK2,PSTPIP1 FOUNDER_NAMES