STANDARD_NAME KEGG_OLFACTORY_TRANSDUCTION SYSTEMATIC_NAME M14091 COLLECTION C2:CP:KEGG_LEGACY MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_OLFACTORY_TRANSDUCTION NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF Olfactory transduction DESCRIPTION_FULL Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.Longer exposure to odorants can stimulate particulate guanylyl cyclase in cilia to produce cGMP and activate PKG, leading to a further increase in amount and duration of intracellular cAMP levels, which may serve to convert inactive forms of protein kinase A (PKA2) to active forms (PKA*). As part of a feedback loop, PKA can inhibit the activation of particulate guanylyl cyclase. PMID GEOID AUTHORS CONTRIBUTOR KEGG CONTRIBUTOR_ORG Kyoto Encyclopedia of Genes and Genomes EXACT_SOURCE hsa04740 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL http://www.genome.jp/kegg/pathway/hsa/hsa04740.html SOURCE_MEMBERS 10798,109,1179,119678,119679,119682,119687,119692,119694,119695,119749,119764,119765,119772,119774,120065,120066,120586,120775,120776,120787,120793,120796,121130,121275,121364,122740,122742,122748,124538,1258,125958,125962,125963,1261,1262,126370,126541,127059,127062,127064,127066,127068,127069,127074,127077,127385,127623,128360,128367,128368,128371,128372,130075,134083,135924,135941,135946,135948,138799,138802,138803,138804,138805,138881,138882,138883,143496,143502,143503,144124,144125,150681,157,158131,162998,163688,196335,219417,219428,219429,219431,219432,219436,219437,219438,219447,219453,219464,219469,219473,219477,219479,219482,219484,219487,219493,219858,219865,219869,219870,219873,219874,219875,219952,219954,219956,219957,219958,219959,219960,219965,219968,219981,219982,219983,219986,22802,23538,254783,254786,254879,254973,255725,256144,256148,256892,26188,26189,26211,26212,26219,26245,26246,26248,26333,26338,26339,26476,26492,26493,26494,26496,26529,26531,26532,26533,26534,26538,26539,26648,26658,26659,26664,26682,26683,26686,26689,26692,26696,26707,26716,26735,26737,26740,2774,282763,282770,282775,283092,283093,283111,283159,283160,283162,283189,283297,283365,283694,284383,284433,284521,284532,285659,286362,286365,2978,2979,3000,338662,338674,338675,338751,338755,340980,341152,341276,341416,341418,341568,341799,343169,343171,343172,343173,343406,343563,346517,346525,346528,347168,347169,347468,387748,389090,390036,390037,390038,390054,390058,390059,390061,390063,390064,390066,390067,390072,390075,390077,390078,390079,390081,390083,390084,390093,390113,390142,390144,390151,390152,390154,390155,390157,390162,390167,390168,390174,390181,390191,390195,390197,390199,390201,390260,390261,390264,390265,390275,390321,390323,390326,390327,390429,390431,390433,390436,390437,390439,390442,390445,390538,390648,390649,390882,390883,390892,391107,391109,391112,391114,391189,391190,391191,391192,391194,391195,391196,391211,392138,392309,392376,392390,392391,392392,393046,401427,401665,401666,401667,401992,401993,401994,402135,402317,403239,403253,403257,403282,403284,409,441608,441639,441669,441670,441911,441933,442184,442186,442191,442194,442361,4991,4992,4993,4994,4995,504189,5132,5137,51806,5566,5567,5568,5592,5593,5613,56656,79290,79295,79310,79317,7932,79324,79339,79345,79473,79501,79541,79544,801,805,808,810,81050,81061,81099,81127,81168,81282,81285,81300,81309,81318,81327,81328,81392,81399,81442,81448,81469,81470,81472,815,816,81696,81697,817,81797,818,8383,8385,8386,8387,8388,8390,8392,8590,9626,9635 GENE_SYMBOLS OR5I1,ADCY3,CLCA1,OR52E2,OR52J3,OR51L1,OR51A7,OR51S1,OR51F2,OR52R1,OR4C46,OR4X2,OR4B1,OR52M1,OR52K2,OR5P2,OR5P3,OR8I2,OR2D3,OR2D2,OR52W1,OR56A4,OR56A1,OR10P1,OR10AD1,OR10A7,OR4K14,OR4L1,OR11H6,OR4D2,CNGB1,OR7D4,OR7G1,OR1M1,CNGA3,CNGA4,OR1I1,OR10H4,OR2M5,OR2M3,OR2T12,OR14C36,OR2T34,OR2T10,OR2T4,OR2T11,OR10J5,OR2B11,OR10T2,OR10X1,OR10Z1,OR6K6,OR6N1,OR9A4,OR2Y1,OR9A2,OR2A14,OR6B1,OR2F2,OR13C5,OR13C8,OR13C3,OR13C4,OR13F1,OR1L8,OR1N2,OR1N1,OR52B4,OR52I2,OR51E1,OR10A5,OR2AG1,OR6B3,GRK3,OR1Q1,OR7D2,CALML6,OR56B4,OR8U1,OR4C16,OR4C11,OR4S2,OR4C6,OR5D14,OR5L1,OR5D18,OR5AS1,OR8K5,OR5T2,OR8H1,OR8K3,OR8J1,OR8U3,OR5M3,OR5M8,OR5M11,OR5AR1,OR8B12,OR8G5,OR10G8,OR10G9,OR10S1,OR6T1,OR4D5,OR6Q1,OR9I1,OR9Q1,OR9Q2,OR1S2,OR1S1,OR10Q1,OR5B17,OR5B21,OR5A2,OR5A1,OR4D6,OR4D11,CLCA4,OR52A1,OR6C74,OR6C3,OR2T6,OR1L4,OR52B2,OR4C3,OR4S1,OR51F1,OR1C1,OR1A2,OR2F1,OR2B6,OR1J4,OR2M4,OR2L2,OR2K2,OR7A17,OR5L2,OR5K1,OR10J1,OR8G2P,OR8B8,OR8G1,OR10A3,OR12D2,OR11A1,OR10H3,OR10G3,OR10G2,OR10H2,OR10H1,OR7E24,OR7C2,OR7A5,OR7C1,OR4F4,OR4F3,OR4E2,OR4D1,OR2W1,OR2T1,OR2J2,OR2H1,OR1L3,OR1L1,OR1J2,GNAL,OR51B5,OR10AG1,OR5J2,OR4C13,OR4C12,OR51V1,OR8D1,OR8D2,OR8B4,OR9G4,OR10A4,OR6C6,OR4N4,OR2Z1,OR10H5,OR2L13,OR14A16,OR2V2,OR13C9,OR13D1,GUCA1A,GUCA1B,GUCY2D,OR8D4,OR5F1,OR5AP2,OR52L1,OR2AG2,OR52B6,OR2AT4,OR10A2,OR6C2,OR6C4,OR8S1,OR6S1,OR6F1,OR2W3,OR2T8,OR2T3,OR10R2,OR2T29,OR6V1,OR2A12,OR2A1,OR1J1,OR1B1,OR13H1,OR56B1,OR6B2,OR52K1,OR52I1,OR51D1,OR52A5,OR51B6,OR51M1,OR51Q1,OR51I1,OR51I2,OR52D1,OR52H1,OR52N4,OR52N5,OR52N2,OR52E6,OR52E8,OR52E4,OR56A3,OR56A5,OR10A6,OR4X1,OR5D13,OR5D16,OR8H2,OR8H3,OR5T3,OR5T1,OR8K1,OR5M9,OR5M10,OR5M1,OR9G1,OR5AK2,OR5B12,OR5AN1,OR4D10,OR4D9,OR10V1,OR6X1,OR6M1,OR10G4,OR10G7,OR8A1,OR6C1,OR6C75,OR6C76,OR6C70,OR4N2,OR4K2,OR4K13,OR4K17,OR4N5,OR11G2,OR11H4,OR5AU1,OR4M2,OR4F6,OR4F15,OR7G2,OR7G3,OR7A10,OR10K2,OR10K1,OR6Y1,OR6K3,OR11L1,OR2L8,OR2AK2,OR2L3,OR2M2,OR2T33,OR2M7,OR2G6,OR2A25,OR13J1,OR13C2,OR1L6,OR5C1,OR1K1,OR2A5,OR2A7,OR51T1,OR51A4,OR51A2,OR2T2,OR2T5,OR14I1,OR5K2,OR2A42,OR2T27,OR4A47,OR4C45,OR6C65,OR6C68,ARRB2,OR5B3,OR9K2,OR4Q3,OR4M1,OR10J3,OR13G1,OR2B3,OR2J3,OR14J1,OR10C1,OR2A2,OR1D2,OR1F1,OR2C1,OR3A1,OR3A2,OR8U8,PDC,PDE1C,CALML5,PRKACA,PRKACB,PRKACG,PRKG1,PRKG2,PRKX,OR2S2,OR13A1,OR5H6,OR5H2,OR4K5,OR2H2,OR51G1,OR51B4,OR51B2,OR52N1,OR4F5,OR2A4,OR4K1,CALM1,CALM2,CALM3,CALML3,OR5AC2,OR11H1,OR4F17,OR4K15,OR8J3,OR51G2,OR51E2,OR4P4,OR4C15,OR4A5,OR4A16,OR4A15,OR2AE1,OR4F16,OR6N2,OR6K2,OR2G3,OR2G2,OR2C3,CAMK2A,CAMK2B,OR5V1,OR2B2,CAMK2D,OR12D3,CAMK2G,OR1A1,OR1D4,OR1D5,OR1E1,OR1E2,OR1G1,OR3A3,OR6A2,GUCA1C,CLCA2 FOUNDER_NAMES