STANDARD_NAME	KEGG_O_GLYCAN_BIOSYNTHESIS
SYSTEMATIC_NAME	M6929
COLLECTION	C2:CP:KEGG_LEGACY
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_O_GLYCAN_BIOSYNTHESIS
NAMESPACE	Human_NCBI_Gene_ID
DESCRIPTION_BRIEF	O-Glycan biosynthesis
DESCRIPTION_FULL	O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	KEGG
CONTRIBUTOR_ORG	Kyoto Encyclopedia of Genes and Genomes
EXACT_SOURCE	hsa00512
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	http://www.genome.jp/pathway/hsa00512
SOURCE_MEMBERS	11226,11227,114805,117248,168391,192134,2589,2590,2591,26290,2650,29071,374378,442117,50614,51301,51809,55568,55808,56913,57452,63917,64409,6482,6483,79623,79695,8693,9245,9334
GENE_SYMBOLS	GALNT6,GALNT5,GALNT13,GALNT15,GALNTL5,B3GNT6,GALNT1,GALNT2,GALNT3,GALNT8,GCNT1,C1GALT1C1,GALNT18,GALNTL6,GALNT9,GCNT4,GALNT7,GALNT10,ST6GALNAC1,C1GALT1,GALNT16,GALNT11,GALNT17,ST3GAL1,ST3GAL2,GALNT14,GALNT12,GALNT4,GCNT3,B4GALT5
FOUNDER_NAMES