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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="KEGG_O_GLYCAN_BIOSYNTHESIS" SYSTEMATIC_NAME="M6929" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="hsa00512" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="http://www.genome.jp/pathway/hsa00512" CHIP="Human_NCBI_Gene_ID" CONTRIBUTOR="KEGG" CONTRIBUTOR_ORG="Kyoto Encyclopedia of Genes and Genomes" DESCRIPTION_BRIEF="O-Glycan biosynthesis" DESCRIPTION_FULL="O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine." TAGS="" MEMBERS="11226,11227,114805,117248,168391,192134,2589,2590,2591,26290,2650,29071,374378,442117,50614,51301,51809,55568,55808,56913,57452,63917,64409,6482,6483,79623,79695,8693,9245,9334" MEMBERS_SYMBOLIZED="B3GNT6,B4GALT5,C1GALT1,C1GALT1C1,GALNT1,GALNT10,GALNT11,GALNT12,GALNT13,GALNT14,GALNT15,GALNT16,GALNT17,GALNT18,GALNT2,GALNT3,GALNT4,GALNT5,GALNT6,GALNT7,GALNT8,GALNT9,GALNTL5,GALNTL6,GCNT1,GCNT3,GCNT4,ST3GAL1,ST3GAL2,ST6GALNAC1" MEMBERS_EZID="11226,11227,114805,117248,168391,192134,2589,2590,2591,26290,2650,29071,374378,442117,50614,51301,51809,55568,55808,56913,57452,63917,64409,6482,6483,79623,79695,8693,9245,9334" MEMBERS_MAPPING="11226,GALNT6,11226|11227,GALNT5,11227|114805,GALNT13,114805|117248,GALNT15,117248|168391,GALNTL5,168391|192134,B3GNT6,192134|2589,GALNT1,2589|2590,GALNT2,2590|2591,GALNT3,2591|26290,GALNT8,26290|2650,GCNT1,2650|29071,C1GALT1C1,29071|374378,GALNT18,374378|442117,GALNTL6,442117|50614,GALNT9,50614|51301,GCNT4,51301|51809,GALNT7,51809|55568,GALNT10,55568|55808,ST6GALNAC1,55808|56913,C1GALT1,56913|57452,GALNT16,57452|63917,GALNT11,63917|64409,GALNT17,64409|6482,ST3GAL1,6482|6483,ST3GAL2,6483|79623,GALNT14,79623|79695,GALNT12,79695|8693,GALNT4,8693|9245,GCNT3,9245|9334,B4GALT5,9334" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:KEGG_LEGACY"/>
</MSIGDB>
