STANDARD_NAME KEGG_P53_SIGNALING_PATHWAY SYSTEMATIC_NAME M6370 COLLECTION C2:CP:KEGG_LEGACY MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_P53_SIGNALING_PATHWAY NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF p53 signaling pathway DESCRIPTION_FULL p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. PMID GEOID AUTHORS CONTRIBUTOR KEGG CONTRIBUTOR_ORG Kyoto Encyclopedia of Genes and Genomes EXACT_SOURCE hsa04115 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL http://www.genome.jp/kegg/pathway/hsa/hsa04115.html SOURCE_MEMBERS 1017,1019,1021,1026,1029,10912,1111,11200,143686,1643,1647,25898,27113,27244,2810,317,3479,3486,355,3732,4193,4194,4616,472,50484,5054,51246,51512,5268,5366,54205,545,55240,55367,56475,5728,575,581,595,6241,637,63970,64065,64326,64393,6477,651610,7057,7157,7161,7249,836,83667,841,842,8493,85417,8795,891,894,896,898,900,901,9133,9134,9538,9540,983 GENE_SYMBOLS CDK2,CDK4,CDK6,CDKN1A,CDKN2A,GADD45G,CHEK1,CHEK2,SESN3,DDB2,GADD45A,RCHY1,BBC3,SESN1,SFN,APAF1,IGF1,IGFBP3,FAS,CD82,MDM2,MDM4,GADD45B,ATM,RRM2B,SERPINE1,SHISA5,GTSE1,SERPINB5,PMAIP1,CYCS,ATR,STEAP3,PIDD1,RPRM,PTEN,ADGRB1,BAX,CCND1,RRM2,BID,TP53AIP1,PERP,COP1,ZMAT3,SIAH1,,THBS1,TP53,TP73,TSC2,CASP3,SESN2,CASP8,CASP9,PPM1D,CCNB3,TNFRSF10B,CCNB1,CCND2,CCND3,CCNE1,CCNG1,CCNG2,CCNB2,CCNE2,EI24,TP53I3,CDK1 FOUNDER_NAMES