STANDARD_NAME KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS SYSTEMATIC_NAME M4741 COLLECTION C2:CP:KEGG_LEGACY MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF Systemic lupus erythematosus DESCRIPTION_FULL Systemic lupus erythematosus (SLE) is characterized by circulating IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc-gamma-R-mediated neutrophil and macrophage activation. Activation of complement leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases. PMID GEOID AUTHORS CONTRIBUTOR KEGG CONTRIBUTOR_ORG Kyoto Encyclopedia of Genes and Genomes EXACT_SOURCE hsa05322 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL http://www.genome.jp/kegg/pathway/hsa/hsa05322.html SOURCE_MEMBERS 121504,126961,128312,1511,158983,1991,2209,2212,2213,2214,2215,221613,255626,286436,2903,2904,3012,3013,3014,3015,3017,3018,3020,3021,3108,3109,3111,3112,3113,3115,3117,3118,3119,3122,3123,3125,3126,3127,317772,333932,340096,3458,3586,391769,440093,440689,474381,474382,554313,55506,55766,644950,651868,653604,6628,6632,6634,6737,6738,6741,712,7124,713,714,715,716,717,718,720,721,723790,727,729,730,731,732,733,735,81,8290,8294,8329,8330,8331,8332,8334,8335,8336,8337,8338,8339,8340,8341,8342,8343,8344,8345,8346,8347,8348,8349,8350,8351,8352,8353,8354,8355,8356,8357,8358,8359,8360,8361,8362,8363,8364,8365,8366,8367,8368,8369,8370,83740,85235,85236,87,88,89,8968,8969,8970,9103,92815,940,941,942,94239,9555,958,959 GENE_SYMBOLS H4C16,H3C14,H2BC26,CTSG,H2BW1,ELANE,FCGR1A,FCGR2A,FCGR2B,FCGR3A,FCGR3B,H2AC1,H2BC1,H2BW2,GRIN2A,GRIN2B,H2AC8,H2AC7,H2AX,H2AZ1,H2BC5,H2BC3,H3-3A,H3-3B,HLA-DMA,HLA-DMB,HLA-DOA,HLA-DOB,HLA-DPA1,HLA-DPB1,HLA-DQA1,HLA-DQA2,HLA-DQB1,HLA-DRA,HLA-DRB1,HLA-DRB3,HLA-DRB4,HLA-DRB5,H2AC21,H3C15,H3Y2,IFNG,IL10,H3Y1,H3-5,H2BC18,H2AB2,H2AB1,H4C15,MACROH2A2,H2AJ,,H2ACP1,H3C13,SNRPB,SNRPD1,SNRPD3,TRIM21,RO60,SSB,C1QA,TNF,C1QB,C1QC,C1R,C1S,C2,C3,C4A,C4B,H2AC19,C5,C6,C7,C8A,C8B,C8G,C9,ACTN4,H3-4,H4C9,H2AC13,H2AC15,H2AC14,H2AC16,H2AC6,H2AC4,H2AC17,H2AC18,H2AC20,H2BC8,H2BC13,H2BC15,H2BC14,H2BC7,H2BC6,H2BC9,H2BC10,H2BC4,H2BC17,H2BC21,H3C1,H3C4,H3C3,H3C6,H3C11,H3C8,H3C12,H3C10,H3C2,H4C1,H4C4,H4C6,H4C12,H4C11,H4C3,H4C8,H4C2,H4C5,H4C13,H4C7,H4C14,H2AB3,H2AC12,H2BC12,ACTN1,ACTN2,ACTN3,H3C7,H2AC11,H2BC11,FCGR2C,H2AC25,CD28,CD80,CD86,H2AZ2,MACROH2A1,CD40,CD40LG FOUNDER_NAMES