STANDARD_NAME	KEGG_VIBRIO_CHOLERAE_INFECTION
SYSTEMATIC_NAME	M17906
COLLECTION	C2:CP:KEGG_LEGACY
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_VIBRIO_CHOLERAE_INFECTION
NAMESPACE	Human_NCBI_Gene_ID
DESCRIPTION_BRIEF	Vibrio cholerae infection
DESCRIPTION_FULL	Cholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, the entire CTX complex is carried from plasma membrane (PM) to endoplasmic reticulum (ER). In the ER, the A-chain (CTXA) is recognized by protein disulfide isomerase (PDI), unfolded, and delivered to the membrane where the membrane-associated ER-oxidase, Ero1, oxidizes PDI to release the CTXA into the protein-conducting channel, Sec61. CTXA is then retro-translocated to the cytosol and induces water and electrolyte secretion by increasing cAMP levels via adenylate cyclase (AC) to exert toxicity. Other than CTX, Vibrio cholerae generates several toxins that are perilous to eukaryotic cells. Zonula occludens toxin (ZOT) causes tight junction disruption through protein kinase C-dependent actin polymerization. RTX toxin (RtxA) causes actin depolymerization by covalently cross-linking actin monomers into dimers, trimers, and higher multimers. Vibrio cholerae cytolysin (VCC) is an important pore-forming toxin. The assembly of VCC anion channels in cells cause vacuolization and lysis.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	KEGG
CONTRIBUTOR_ORG	Kyoto Encyclopedia of Genes and Genomes
EXACT_SOURCE	hsa05110
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	http://www.genome.jp/pathway/hsa05110
SOURCE_MEMBERS	10312,1080,109,10945,10952,11014,11015,115,127124,155066,23480,23545,245972,245973,2778,29927,30001,375,3784,4583,50617,51382,51606,523,525,526,527,528,529,533,5335,5336,534,535,537,55176,5566,5567,5568,5578,5579,5582,5613,60,646048,646821,6558,7082,71,8992,90423,9114,9296,9414,9550,9601
GENE_SYMBOLS	TCIRG1,CFTR,ADCY3,KDELR1,SEC61B,KDELR2,KDELR3,ADCY9,ATP6V1G3,ATP6V0E2,SEC61G,ATP6V0A2,ATP6V0D2,ATP6V1C2,GNAS,SEC61A1,ERO1A,ARF1,KCNQ1,MUC2,ATP6V0A4,ATP6V1D,ATP6V1H,ATP6V1A,ATP6V1B1,ATP6V1B2,ATP6V0C,ATP6V1C1,ATP6V1E1,ATP6V0B,PLCG1,PLCG2,ATP6V1G2,ATP6V0A1,ATP6AP1,SEC61A2,PRKACA,PRKACB,PRKACG,PRKCA,PRKCB,PRKCG,PRKX,ACTB,,,SLC12A2,TJP1,ACTG1,ATP6V0E1,ATP6V1E2,ATP6V0D1,ATP6V1F,TJP2,ATP6V1G1,PDIA4
FOUNDER_NAMES