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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="KHETCHOUMIAN_TRIM24_TARGETS_UP" SYSTEMATIC_NAME="M1399" HISTORICAL_NAMES="" PMID="18026104" AUTHORS="Khetchoumian K,Teletin M,Tisserand J,Mark M,Herquel B,Ignat M,Zucman-Rossi J,Cammas F,Lerouge T,Thibault C,Metzger D,Chambon P,Losson R" GEOID="GSE9012" EXACT_SOURCE="Table 2S: FC &gt; 2" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_Mouse430" CONTRIBUTOR="Leona Saunders" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Retinoic acid-responsive genes up-regulated in hepatocellular carcinoma (HCC) samples of TRIM24 [GeneID=8805] knockout mice." DESCRIPTION_FULL="Hepatocellular carcinoma (HCC) is a major cause of death worldwide. Here, we provide evidence that the ligand-dependent nuclear receptor co-regulator Trim24 (also known as Tif1alpha) functions in mice as a liver-specific tumor suppressor. In Trim24-null mice, hepatocytes fail to execute proper cell cycle withdrawal during the neonatal-to-adult transition and continue to cycle in adult livers, becoming prone to a continuum of cellular alterations that progress toward metastatic HCC. Using pharmacological approaches, we show that inhibition of retinoic acid signaling markedly reduces hepatocyte proliferation in Trim24-/- mice. We further show that deletion of a single retinoic acid receptor alpha (Rara) allele in a Trim24-null background suppresses HCC development and restores wild-type expression of retinoic acid-responsive genes in the liver, thus demonstrating that in this genetic background Rara expresses an oncogenic activity correlating with a dysregulation of the retinoic acid signaling pathway. Our results not only provide genetic evidence that Trim24 and Rara co-regulate hepatocarcinogenesis in an antagonistic manner but also suggest that aberrant activation of Rara is deleterious to liver homeostasis." TAGS="" MEMBERS="1415899_at,1415989_at,1416529_at,1416589_at,1416645_a_at,1417065_at,1417401_at,1418350_at,1419149_at,1419573_a_at,1420621_a_at,1420653_at,1420847_a_at,1421198_at,1422978_at,1423100_at,1423110_at,1423669_at,1423760_at,1424051_at,1424067_at,1424594_at,1424638_at,1426004_a_at,1426397_at,1426538_a_at,1426808_at,1433741_at,1435560_at,1436905_x_at,1438118_x_at,1441326_at,1448152_at,1448169_at,1448194_a_at,1448261_at,1448272_at,1448595_a_at,1448754_at,1449152_at,1449187_at,1449254_at,1449265_at,1449455_at,1450033_a_at,1452035_at,1459740_s_at" MEMBERS_SYMBOLIZED="AFP,APP,BEX1,BTG2,CASP1,CD38,CD44,CDH1,CDKN1A,CDKN2B,COL1A1,COL1A2,COL4A1,COL4A2,CP,CYBB,EGR1,EMP1,FGFR2,FOS,H19,HBEGF,HCK,ICAM1,IGF2,ITGAL,ITGAV,JUNB,KRT18,LAPTM5,LGALS1,LGALS3,PDGFA,RAI14,RBP1,SAMD4A,SERPINE1,SPARC,SPP1,STAT1,TGFB1,TGFBR2,TGM2,TP53,UCP2,VCAM1,VIM" MEMBERS_EZID="1026,1030,1277,1278,1282,1284,1356,1536,174,1839,1958,2012,2263,23034,2353,26064,283120,3055,3383,3481,351,3683,3685,3726,3875,3956,3958,5054,5154,55859,5947,6678,6696,6772,7040,7048,7052,7157,7351,7412,7431,7805,7832,834,952,960,999" MEMBERS_MAPPING="1415899_at,JUNB,3726|1415989_at,VCAM1,7412|1416529_at,EMP1,2012|1416589_at,SPARC,6678|1416645_a_at,AFP,174|1417065_at,EGR1,1958|1417401_at,RAI14,26064|1418350_at,HBEGF,1839|1419149_at,SERPINE1,5054|1419573_a_at,LGALS1,3956|1420621_a_at,APP,351|1420653_at,TGFB1,7040|1420847_a_at,FGFR2,2263|1421198_at,ITGAV,3685|1422978_at,CYBB,1536|1423100_at,FOS,2353|1423110_at,COL1A2,1278|1423669_at,COL1A1,1277|1423760_at,CD44,960|1424051_at,COL4A2,1284|1424067_at,ICAM1,3383|1424594_at,SAMD4A,23034|1424638_at,CDKN1A,1026|1426004_a_at,TGM2,7052|1426397_at,TGFBR2,7048|1426538_a_at,TP53,7157|1426808_at,LGALS3,3958|1433741_at,CD38,952|1435560_at,ITGAL,3683|1436905_x_at,LAPTM5,7805|1438118_x_at,VIM,7431|1441326_at,CP,1356|1448152_at,IGF2,3481|1448169_at,KRT18,3875|1448194_a_at,H19,283120|1448261_at,CDH1,999|1448272_at,BTG2,7832|1448595_a_at,BEX1,55859|1448754_at,RBP1,5947|1449152_at,CDKN2B,1030|1449187_at,PDGFA,5154|1449254_at,SPP1,6696|1449265_at,CASP1,834|1449455_at,HCK,3055|1450033_a_at,STAT1,6772|1452035_at,COL4A1,1282|1459740_s_at,UCP2,7351" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
