STANDARD_NAME KIM_MYC_AMPLIFICATION_TARGETS_DN SYSTEMATIC_NAME M6319 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KIM_MYC_AMPLIFICATION_TARGETS_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes negatively correlated with amplifications of MYC [GeneID=4609] in SCLC (small cell lung cancer) cell lines. DESCRIPTION_FULL DNA amplifications and deletions frequently contribute to the development and progression of lung cancer. To identify such novel alterations in small cell lung cancer (SCLC), we performed comparative genomic hybridization on a set of 24 SCLC cell lines, using cDNA microarrays representing approximately 22,000 human genes (providing an average mapping resolution of <70 kb). We identified localized DNA amplifications corresponding to oncogenes known to be amplified in SCLC, including MYC (8q24), MYCN (2p24) and MYCL1 (1p34). Additional highly localized DNA amplifications suggested candidate oncogenes not previously identified as amplified in SCLC, including the antiapoptotic genes TNFRSF4 (1p36), DAD1 (14q11), BCL2L1 (20q11) and BCL2L2 (14q11). Likewise, newly discovered PCR-validated homozygous deletions suggested candidate tumor-suppressor genes, including the proapoptotic genes MAPK10 (4q21) and TNFRSF6 (10q23). To characterize the effect of DNA amplification on gene expression patterns, we performed expression profiling using the same microarray platform. Among our findings, we identified sets of genes whose expression correlated with MYC, MYCN or MYCL1 amplification, with surprisingly little overlap among gene sets. While both MYC and MYCN amplification were associated with increased and decreased expression of known MYC upregulated and downregulated targets, respectively, MYCL1 amplification was associated only with the latter. Our findings support a role of altered apoptotic balance in the pathogenesis of SCLC, and suggest that MYC family genes might affect oncogenesis through distinct sets of targets, in particular implicating the importance of transcriptional repression. PMID 16116477 GEOID AUTHORS Kim YH,Girard L,Giacomini CP,Wang P,Hernandez-Boussard T,Tibshirani R,Minna JD,Pollack JR CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3S: negatively correlated with MYC FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ADAMTS18,ARGBP2,ATCAY,ATP2B4,BCL2,BF,C15orf20,C1orf31,C1orf32,C1orf39,C6orf152,C9orf39,C9orf52,C9orf93,CANP,CDH1,CEBPD,CFLAR,CGI-119,CTNNA1,DCAMKL1,DDX58,DKFZp564J0863,DNER,DPYSL3,ELF3,ELOVL7,ERO1LB,ETV6,F11R,FAM49A,FLJ10359,FLJ11838,FLJ13842,FLJ21144,FLJ22794,FLJ30092,FLJ46385,GAB2,GAS2L3,GCA,GRP,HMG20B,HS2ST1,IFIH1,IL17RB,IL17RD,INADL,KCNMB2,KIAA0367,KIAA1238,KIAA1407,KIAA1505,KIAA2026,KIF13B,KIRREL3,KITLG,KLF5,LAMP1,LGALS8,LOC400713,LPP,MARVELD2,MGC26979,MYO6,NCRMS,NEBL,NFATC2,NUCB2,OCIL,OPTN,PAXIP1L,PLEKHA2,PLEKHG1,PLXNA2,PTPRN2,RAB3B,RASSF6,RNF19,RNF38,RORA,SCNN1A,ShrmL,SPAG1,SPAG6,TBPL1,TCF19,TFCP2L3,TITF1,XRRA1,ZNF292,ZNF347,ZNF415,ZNF43,ZNF468,ZNF505,ZNF83,ZSWIM6 GENE_SYMBOLS ADAMTS18,SORBS2,ATCAY,ATP2B4,BCL2,CFB,PIF1,COA6,ILDR2,FNBP1L,LCA5,CNTLN,TTC39B,CCDC171,CAPN1,CDH1,CEBPD,CFLAR,TMBIM4,CTNNA1,DCLK1,RIGI,ATL3,DNER,DPYSL3,ELF3,ELOVL7,ERO1B,ETV6,F11R,CYRIA,HEATR1,PPCS,ZMAT4,EXO5,FAM111A,HECTD4,ZNF818P,GAB2,GAS2L3,GCA,GRP,HMG20B,HS2ST1,IFIH1,IL17RB,IL17RD,PATJ,KCNMB2,PRUNE2,RIMKLB,CCDC191,CCDC146,KIAA2026,KIF13B,KIRREL3,KITLG,KLF5,LAMP1,LGALS8,ZNF880,LPP,MARVELD2,TMEM67,MYO6,RMST,NEBL,NFATC2,NUCB2,CLEC2D,OPTN,PAXIP1,PLEKHA2,PLEKHG1,PLXNA2,PTPRN2,RAB3B,RASSF6,RNF19A,RNF38,RORA,SCNN1A,SPAG1,SPAG6,SHROOM3,TBPL1,TCF19,GRHL2,NKX2-1,XRRA1,ZNF292,ZNF347,ZNF415,ZNF43,ZNF468,ZNF93,ZNF83,ZSWIM6 FOUNDER_NAMES