STANDARD_NAME	KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN
SYSTEMATIC_NAME	M18825
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN
NAMESPACE	AFFY_HG_U95
DESCRIPTION_BRIEF	Genes down-regulated in AIDS-related primary effusion lymphoma (PEL) samples compared to other tumor subtypes and normal B lymphocytes.
DESCRIPTION_FULL	AIDS-related primary effusion lymphoma (PEL) is an HIV-associated malignancy characterized by the ability of the tumor cells to specifically home in the serous body cavities. Here we used gene expression profile analysis (about 12 000 genes) to further define the phenotype of PEL and to investigate the lymphoma relationship to normal B cells and to other tumor subtypes, including non-Hodgkin lymphomas (NHLs) of immunocompetent hosts and AIDS-associated NHL (AIDS-NHL). The results showed that PEL displayed a common gene expression profile that is clearly distinct from all NHLs of immunocompetent hosts and AIDS-NHL subtypes and, in contrast to those, is not related to germinal center (GC) or memory B cells. The gene expression profile of PEL was defined as plasmablastic because it showed features of both immunoblasts identified by Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and AIDS immunoblastic lymphoma, and plasma cells, as defined by multiple myeloma cell lines. Finally, our results identify a set of genes specifically expressed in PEL tumor cells. Their expression was validated at the protein level, suggesting their potential pathogenetic and clinical significance.
PMID	12531789
GEOID	
AUTHORS	Klein U,Gloghini A,Gaidano G,Chadburn A,Cesarman E,Dalla-Favera R,Carbone A
CONTRIBUTOR	Kate Stafford
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1003_s_at,1004_at,1096_g_at,1518_at,1717_s_at,1977_s_at,266_s_at,31869_at,32941_at,33396_at,33999_f_at,34000_r_at,34210_at,34224_at,34376_at,34498_at,35149_at,35238_at,35883_at,35974_at,36009_at,36192_at,36595_s_at,36634_at,36773_f_at,36812_at,36878_f_at,37021_at,37043_at,37112_at,37162_at,37344_at,37406_at,37417_at,37479_at,37565_at,37598_at,37692_at,37974_at,37988_at,38017_at,38018_g_at,38075_at,38242_at,38391_at,38522_s_at,38578_at,38774_at,38893_at,38894_g_at,38968_at,38992_at,39929_at,40621_at,40723_at,40749_at,41337_at,41352_at,41355_at,41356_at,41503_at,41585_at,41609_at,41790_at,619_s_at,794_at,829_s_at
GENE_SYMBOLS	CXCR5,CXCR5,CD19,ETS1,BIRC3,ETS1,CD24,SWAP70,IRF8,GSTP1,IGHV5-78,IGHV5-78,CD52,FADS3,PKIG,VNN2,CD40,TRAF5,SPIB,IRAG2,GPX7,SCRN1,GATM,BTG2,HLA-DQB1,BCAR3,HLA-DQB1,CTSH,ID3,RIPOR2,CCDC6,HLA-DMA,MAPRE2,POU2F2,CD72,MMD,RASSF2,DBI,MSL3,CD79B,CD79A,CD79A,SYPL1,BLNK,CAPG,CD22,CD27,STX7,NCF4,NCF4,SH3BP5,DEK,TMEM131L,PAWR,SIT1,MS4A1,TLE5,ST6GAL1,BCL11A,,ZHX2,SEL1L3,HLA-DMB,ALDH5A1,MS4A1,PTPN6,GSTP1
FOUNDER_NAMES