STANDARD_NAME	KOHN_EMT_EPITHELIAL
SYSTEMATIC_NAME	M46416
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KOHN_EMT_EPITHELIAL
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Epithelial phenotype associated genes from an Epithelial-Mesenchymal Transition (EMT) gene set allowing sample stratification into epithelial, mesenchymal, and epithelial-mesenchymal categories initially developed on the NCI-60 cell line collection.
DESCRIPTION_FULL	Expression-correlated genes were derived from data for the NCI-60 human tumor cell lines, as well as data from the Broad Institute's CCLE cell lines. NCI-60 cell lines that selectively expressed a mutually correlated subset of tight junction genes served as a signature for epithelial-like cancer cells. Those signature cell lines served as a seed to derive other correlated genes, many of which had various other epithelial-related functions. Literature survey yielded molecular interaction and function information about those genes, from which molecular interaction maps were assembled. Many of the genes had epithelial functions unrelated to tight junctions, demonstrating that new function categories were elicited. The most highly correlated genes were implicated in the following epithelial functions: interactions at tight junctions (CLDN7, CLDN4, CLDN3, MARVELD3, MARVELD2, TJP3, CGN, CRB3, LLGL2, EPCAM, LNX1); interactions at adherens junctions (CDH1, ADAP1, CAMSAP3); interactions at desmosomes (PPL, PKP3, JUP); transcription regulation of cell-cell junction complexes (GRHL1 and 2); epithelial RNA splicing regulators (ESRP1 and 2); epithelial vesicle traffic (RAB25, EPN3, GRHL2, EHF, ADAP1, MYO5B); epithelial Ca(+2) signaling (ATP2C2, S100A14, BSPRY); terminal differentiation of epithelial cells (OVOL1 and 2, ST14, PRSS8, SPINT1 and 2); maintenance of apico-basal polarity (RAB25, LLGL2, EPN3).
PMID	30553813
GEOID	
AUTHORS	Rajapakse VN,Luna A,Yamade M,Loman L,Varma S,Sunshine M,Iorio F,Sousa FG,Elloumi F,Aladjem MI,Thomas A,Sander C,Kohn KW,Benes CH,Garnett M,Reinhold WC,Pommier Y
CONTRIBUTOR	Augustin Luna
CONTRIBUTOR_ORG	Broad Institute
EXACT_SOURCE	PMID: 30553813 FIG 7A. Genes associated with the Epithelial phenotype of the EMT Gene Expression Signature
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ADAP1,ATP2C2,CLDN3,CLDN4,CLDN7,EHF,EPN3,ESRP1,ESRP2,GRHL1,GRHL2,IRF6,LLGL2,MARVELD2,MARVELD3,MYO5B,OVOL1,PRSS8,RAB25,S100A14,ST14,TJP3
GENE_SYMBOLS	ADAP1,ATP2C2,CLDN3,CLDN4,CLDN7,EHF,EPN3,ESRP1,ESRP2,GRHL1,GRHL2,IRF6,LLGL2,MARVELD2,MARVELD3,MYO5B,OVOL1,PRSS8,RAB25,S100A14,ST14,TJP3
FOUNDER_NAMES