STANDARD_NAME KUMAR_AUTOPHAGY_NETWORK SYSTEMATIC_NAME M2539 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KUMAR_AUTOPHAGY_NETWORK NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes defining the Mycobacterium tuberculosis strain-independent regulatory axis of the host macrophage cells. DESCRIPTION_FULL We performed a genome-wide siRNA screen to identify host factors that regulated pathogen load in human macrophages infected with a virulent strain of Mycobacterium tuberculosis. Iterative rounds of confirmation, followed by validation, identified 275 such molecules that were all found to functionally associate with each other through a dense network of interactions. This network then yielded to a molecular description of the host cell functional modules that were both engaged and perturbed by the pathogen. Importantly, a subscreen against a panel of field isolates revealed that the molecular composition of the host interface varied with both genotype and the phenotypic properties of the pathogen. An analysis of these differences, however, permitted identification of those host factors that were invariantly involved, regardless of the diversification in adaptive mechanisms employed by the pathogen. Interestingly, these factors were found to predominantly function through the regulation of autophagy. PMID 20211141 GEOID GSE19052 AUTHORS Kumar D,Nath L,Kamal MA,Varshney A,Jain A,Singh S,Rao KV CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 9S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABTB2,ACAT2,ACTL6,ARPP-19,BMP1,C10orf12,C10orf91,C1orf2,C20orf174,C20orf43,C21orf33,C9orf21,CDAN1,CDH6,CNN1,CPS1,CPZ,CRX,DIRAS1,DKFZp434G0625,EMP2,FGF23,FKSG14,FLJ20557,FLJ31842,FLJ39237,FUCA2,GAL3ST3,GALNT2,GPR109A,GUK1,HCP5,HNRPC,INCA,KERA,KIAA1862,KLHL11,KLRF1,LAMB1,LETM2,LGALS9,LOC84661,LST1,LTBP4,MAPK10,MGC10485,MGC14161,MOCS2,MRPL20,MRPL3,MUM1,NEK7,P2RY13,PC-3,PDK1,PDZK11,PGK1,PGM1,PLEKHG2,PROK2,PXK,RELL1,REV3L,RIMS2,SLC26A11,ST8SIA4,TFAP2C,TIM14,TLR8,TOP2A,USP9Y,VCP,ZNF554,ZNF599 GENE_SYMBOLS ABTB2,ACAT2,ACTL6B,ARPP19,BMP1,LCOR,LINC02870,ENTREP3,ZNF831,RTF2,GATD3,PRXL2C,CDAN1,CDH6,CNN1,CPS1,CPZ,CRX,DIRAS1,,EMP2,FGF23,CENPK,ZNF416,TLCD4,NAT16,FUCA2,GAL3ST3,GALNT2,HCAR2,GUK1,HCP5,HNRNPC,CARD17P,KERA,KRBA1,KLHL11,KLRF1,LAMB1,LETM2,LGALS9,DPY30,LST1,LTBP4,MAPK10,VPS26B,FRMD5,MOCS2,MRPL20,MRPL3,IRF4,NEK7,P2RY13,MSMP,PDK1,PDZD11,PGK1,PGM1,PLEKHG2,PROK2,PXK,RELL1,REV3L,RIMS2,SLC26A11,ST8SIA4,TFAP2C,,TLR8,TOP2A,USP9Y,VCP,ZNF554,ZNF599 FOUNDER_NAMES