STANDARD_NAME	KYNG_DNA_DAMAGE_BY_4NQO_OR_GAMMA_RADIATION
SYSTEMATIC_NAME	M19053
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KYNG_DNA_DAMAGE_BY_4NQO_OR_GAMMA_RADIATION
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Genes responding to 4NQO treatment and gamma irradiation.
DESCRIPTION_FULL	The accumulation of DNA damage and mutations is considered a major cause of cancer and aging. While it is known that DNA damage can affect changes in gene expression, transcriptional regulation after DNA damage is poorly understood. We characterized the expression of 6912 genes in human primary fibroblasts after exposure to three different kinds of cellular stress that introduces DNA damage: 4-nitroquinoline-1-oxide (4NQO), gamma-irradiation, or UV-irradiation. Each type of stress elicited damage specific gene expression changes of up to 10-fold. A total of 85 genes had similar changes in expression of 3-40-fold after all three kinds of stress. We examined transcription in cells from young and old individuals and from patients with Werner syndrome (WS), a segmental progeroid condition with a high incidence of cancer, and found various age-associated transcriptional changes depending upon the type of cellular stress. Compared to young individuals, both WS and old individuals had similarly aberrant transcriptional responses to gamma- and UV-irradiation, suggesting a role for Werner protein in stress-induced gene expression. Our results suggest that aberrant DNA damage-induced gene regulation may contribute to the aging process and the premature aging in WS
PMID	15897889
GEOID	
AUTHORS	Kyng KJ,May A,Stevnsner T,Becker KG,Kølvrå S,Bohr VA
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Suppl. Info 2: Table 5S: 4NQO and Gamma [F]
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AA024832,AA151249,AA156859,AA458922,AA464195,AA490124,BC015663,NM_001964,NM_002006,NM_002100,NM_005228,NM_005232,NM_031226,R27776,W51951
GENE_SYMBOLS	LIMS1,PPOX,FAN1,AGPAT1,PPP1R12C,UBE2N,SERPINE2,EGR1,FGF2,GYPB,EGFR,EPHA1,CYP19A1,LRRFIP2,DCTD
FOUNDER_NAMES