STANDARD_NAME	LANDEMAINE_LUNG_METASTASIS
SYSTEMATIC_NAME	M5914
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LANDEMAINE_LUNG_METASTASIS
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Genes associated with metastasis of breast cancer in the lung compared to the non-lung metastasis.
DESCRIPTION_FULL	The lungs are a frequent target of metastatic breast cancer cells, but the underlying molecular mechanisms are unclear. All existing data were obtained either using statistical association between gene expression measurements found in primary tumors and clinical outcome, or using experimentally derived signatures from mouse tumor models. Here, we describe a distinct approach that consists of using tissue surgically resected from lung metastatic lesions and comparing their gene expression profiles with those from nonpulmonary sites, all coming from breast cancer patients. We show that the gene expression profiles of organ-specific metastatic lesions can be used to predict lung metastasis in breast cancer. We identified a set of 21 lung metastasis-associated genes. Using a cohort of 72 lymph node-negative breast cancer patients, we developed a 6-gene prognostic classifier that discriminated breast primary cancers with a significantly higher risk of lung metastasis. We then validated the predictive ability of the 6-gene signature in 3 independent cohorts of breast cancers consisting of a total of 721 patients. Finally, we show that the signature improves risk stratification independently of known standard clinical variables and a previously established lung metastasis signature based on an experimental breast cancer metastasis model.
PMID	18676831
GEOID	GSE11078
AUTHORS	Landemaine T,Jackson A,Bellahcène A,Rucci N,Sin S,Abad BM,Sierra A,Boudinet A,Guinebretière JM,Ricevuto E,Noguès C,Briffod M,Bièche I,Cherel P,Garcia T,Castronovo V,Teti A,Lidereau R,Driouch K
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1553705_a_at,1554246_at,203256_at,204751_x_at,205428_s_at,208103_s_at,211488_s_at,213372_at,219867_at,220941_s_at,221705_s_at,222869_s_at,223861_at,225363_at,226075_at,227642_at,227829_at,228171_s_at,228577_x_at,228956_at,60474_at
GENE_SYMBOLS	CHRM3,C1orf210,CDH3,DSC2,CALB2,ANP32E,ITGB8,PAQR3,CHODL,C21orf91,SIKE1,ELAC1,HORMAD1,PTEN,SPSB1,TFCP2L1,LARGE2,PLEKHG4,ODF2L,UGT8,FERMT1
FOUNDER_NAMES