STANDARD_NAME LEE_LIVER_CANCER_CIPROFIBRATE_UP SYSTEMATIC_NAME M2195 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LEE_LIVER_CANCER_CIPROFIBRATE_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in hepatocellular carcinoma (HCC) induced by ciprofibrate [PubChem=2763]. DESCRIPTION_FULL Genetically modified mice have been extensively used for analyzing the molecular events that occur during tumor development. In many, if not all, cases, however, it is uncertain to what extent the mouse models reproduce features observed in the corresponding human conditions. This is due largely to lack of precise methods for direct and comprehensive comparison at the molecular level of the mouse and human tumors. Here we use global gene expression patterns of 68 hepatocellular carcinomas (HCCs) from seven different mouse models and 91 human HCCs from predefined subclasses to obtain direct comparison of the molecular features of mouse and human HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc E2f1 transgenic mice were most similar to those of the better survival group of human HCCs, whereas the expression patterns in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced mouse HCCs were most similar to those of the poorer survival group of human HCCs. Gene expression patterns in HCCs from Acox1(-/-) mice and in ciprofibrate-induced HCCs were least similar to those observed in human HCCs. We conclude that our approach can effectively identify appropriate mouse models to study human cancers. PMID 15565109 GEOID GSE1897 AUTHORS Lee JS,Chu IS,Mikaelyan A,Calvisi DF,Heo J,Reddy JK,Thorgeirsson SS CONTRIBUTOR Yujin Hoshida CONTRIBUTOR_ORG Broad Institute EXACT_SOURCE GSE1897: top 100 up-regulated in CIP; convertied to human orthologs FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABHD2,ADFP,ALDH3A2,APCS,BRCA1,BSG,C1orf24,CBFA2T3,CD24,CD36,CD63,CDKN1A,CHKB,CHKB /// CPT1B,CIDEA,CIDEC,COL4A1,COL4A2,CTSE,DAB1,EHHADH,ETS2,FABP4,GATM,GIPC2,HOXC6,IGFBP1,IGFBP2,KIFAP3,KRT23,LCN2,LEPR,LPL,LY6D,MFGE8,MLYCD,MT2A,MYO5C,NT5E,NUP205,PDK4,PEX11A,PLA2G7,PLAT,PLTP,PMM1,QPCT,RAB30,RAD51L1,S100A9,SLC16A1,SLC24A3,SPON2,SPRR1A,TES,TFF3,TGM2,TM4SF4,UCP2,VNN1,VNN3 GENE_SYMBOLS ABHD2,PLIN2,ALDH3A2,APCS,BRCA1,BSG,NIBAN1,CBFA2T3,CD24,CD36,CD63,CDKN1A,CHKB,,CIDEA,CIDEC,COL4A1,COL4A2,CTSE,DAB1,EHHADH,ETS2,FABP4,GATM,GIPC2,HOXC6,IGFBP1,IGFBP2,KIFAP3,KRT23,LCN2,LEPR,LPL,LY6D,MFGE8,MLYCD,MT2A,MYO5C,NT5E,NUP205,PDK4,PEX11A,PLA2G7,PLAT,PLTP,PMM1,QPCT,RAB30,RAD51B,S100A9,SLC16A1,SLC24A3,SPON2,SPRR1A,TES,TFF3,TGM2,TM4SF4,UCP2,VNN1,VNN3P FOUNDER_NAMES