STANDARD_NAME	LIANG_PANCREATIC_CANCER_DENDRITIC_CELL_GENES
SYSTEMATIC_NAME	M50220
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LIANG_PANCREATIC_CANCER_DENDRITIC_CELL_GENES
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	20 genes exhibiting Hazard Ratios >1 of the 22 genes significantly associated with overall survival in the TCGA-PDAC training Cohort by univariate Cox regression. Higher expression of this gene set is associated worse overall survival.
DESCRIPTION_FULL	This gene set comprises 22 dendritic cell-related genes identified from WGCNA modules correlated with dendritic cell infiltration in pancreatic ductal adenocarcinoma cohorts. The genes were selected based on their association with overall survival and DC-related expression patterns. Using these genes, unsupervised consensus clustering stratified TCGA-PAAD patients into cluster 1 and cluster 2. The authors report that cluster 2 exhibited higher expression of DC-related genes and significantly poorer overall survival, whereas cluster 1 showed lower expression and better survival. These genes were further used to derive a dendritic cell-related risk score (DCRS). Patients with a high DCRS (corresponding to cluster 2) had significantly worse overall survival than those with a low DCRS (corresponding to cluster 1).
PMID	41080575
GEOID	
AUTHORS	Liang Y,Gu Y,Zhang Z,Zhong D,Yan H,Su Y,Chen Y,Wang F,Leng Z,Huang X
CONTRIBUTOR	Anthony Castanza
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Data Sheet 1, Figure S2. Selected Genes exhibiting a Hazard Ratio >1 (20/22 genes).  GNG7 and CD81 were excluded on this basis.
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1665906/full
SOURCE_MEMBERS	ANLN,ARHGAP32,ARL14,CHMP4C,DSG2,ESRP1,GBP1,GJB3,H2BC4,KCTD14,LAMA3,LIPH,LMO7,MMP28,MYEOV,PLEK2,PLS1,PPP1R14D,SFTA2,XK
GENE_SYMBOLS	ANLN,ARHGAP32,ARL14,CHMP4C,DSG2,ESRP1,GBP1,GJB3,H2BC4,KCTD14,LAMA3,LIPH,LMO7,MMP28,MYEOV,PLEK2,PLS1,PPP1R14D,SFTA2,XK
FOUNDER_NAMES