STANDARD_NAME	LINDSTEDT_DENDRITIC_CELL_MATURATION_B
SYSTEMATIC_NAME	M12480
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LINDSTEDT_DENDRITIC_CELL_MATURATION_B
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated both at 8 hr and 48 hr after the stimulation (cluster B).
DESCRIPTION_FULL	Maturation of dendritic cells (DC) serves a deterministic role in the link between innate and adaptive immunity, constituting a checkpoint with regard to whether responses from the lymphocyte compartment shall be raised and what class of response is needed to protect the host against invading pathogens. Since DC have not been shown to possess mechanisms such as gene recombination or somatic mutation for generating a diverse repertoire of antigen-recognition receptors, it is unlikely that these leukocytes can intrinsically respond to all conceivable molecules present in our environment. In the present study, we have therefore determined how mediators of the inflammatory response regulate global gene transcription in DC. The data represent an extensive and time-ordered reprogramming of the DC during their course of maturation, involving genes encoding proteins that regulate responses of both innate cells and lymphocytes. This transcriptional reorganization may reflect the effect of in vivo released inflammatory mediators induced by endogenous or pathogenic stimulation.
PMID	12356685
GEOID	
AUTHORS	Lindstedt M,Johansson-Lindbom B,Borrebaeck CA
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AB013924,AB023137,AF005775,AF015451,AF022789,AF043129,AF058696,AF061034,AF068836,AF072468,AF080227,AJ011896,AL021977,D10522,D13891,D14520,D14874,D45248,D78579,D79206,L06797,M16038,M27533,M58603,M59465,M60974,M69043,M73832,M83221,M92357,S46950,S76638,U03105,U03397,U12767,U17760,U19261,U20816,U31628,U33017,U45878,U48807,U50529,U60207,U67319,U76248,X01057,X06374,X51435,X57522,X61123,X61498,X70326,X75042,X78925,Y10256,Z11697
GENE_SYMBOLS	LAMP3,PALM2AKAP2,CFLAR,CFLAR,USP12,,NBN,OPTN,CYTIP,JRK,EED,TNIP1,PLA2G6,MARCKS,ID2,KLF5,ADM,PSME2,NR4A3,SDC4,CXCR4,LYN,CD80,NFKB1,TNFAIP3,GADD45A,NFKBIA,CSF2RA,RELB,TNFAIP2,,NFKB2,PNRC1,TNFRSF9,NR4A3,,TRAF1,NFKB2,IL15RA,SLAMF1,BIRC3,DUSP4,N4BP2L2,STK4,,SIAH2,IL2RA,PDGFA,HIVEP1,TAP1,BTG1,NFKB2,MARCKSL1,REL,ZNF267,MAP3K14,CD83
FOUNDER_NAMES