STANDARD_NAME LIU_PROSTATE_CANCER_DN SYSTEMATIC_NAME M19391 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LIU_PROSTATE_CANCER_DN NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes down-regulated in prostate cancer samples. DESCRIPTION_FULL Prostate cancer is the most commonly diagnosed noncutaneous neoplasm and second most common cause of cancer-related mortality in western men. To investigate the mechanisms of prostate cancer development and progression, we did expression profiling of human prostate cancer and benign tissues. We show that the SOX4 is overexpressed in prostate tumor samples compared with benign tissues by microarray analysis, real-time PCR, and immunohistochemistry. We also show that SOX4 expression is highly correlated with Gleason score at the mRNA and protein level using tissue microarrays. Genes affected by SOX4 expression were also identified, including BCL10, CSF1, and NcoA4/ARA70. TLE-1 and BBC3/PUMA were identified as direct targets of SOX4. Silencing of SOX4 by small interfering RNA transfection induced apoptosis of prostate cancer cells, suggesting that SOX4 could be a therapeutic target for prostate cancer. Stable transfection of SOX4 into nontransformed prostate cells enabled colony formation in soft agar, suggesting that, in the proper cellular context, SOX4 can be a transforming oncogene. PMID 16618720 GEOID AUTHORS Liu P,Ramachandran S,Ali Seyed M,Scharer CD,Laycock N,Dalton WB,Williams H,Karanam S,Datta MW,Jaye DL,Moreno CS CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 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GENE_SYMBOLS CSRP1,SRSF11,GSTP1,CTSB,FLNA,EPAS1,HLA-E,PALLD,TACC1,VCL,CCND2,ACTA2,LDHB,MYL9,STOM,LGALS1,TIMP3,TIMP3,AKR1B1,SDC1,SH3BGRL,ENO2,ETS2,ALDH2,DPYSL3,SCRN1,MYH11,MYH11,LAMB1,FHL1,CLIC4,ANXA2,PPP1R12A,KRT19,HSPG2,GJA1,AEBP1,MYOF,KRT5,HSPB1,EFEMP1,EFEMP1,CAPG,PPP1R12B,ACAA2,NID1,ALDH3A2,OPTN,GAS6,DKK3,LAMA4,ACTG2,SERPINF1,COL1A2,IGF2,DENND2B,PRSS23,TRIM29,CRIM1,GSTM3,MYLK,SVIL,SVIL,CRABP2,LTBP1,LTBP1,GBP2,FBN1,NNT,NNT,INPP1,GPX2,WFS1,ANK2,GYPC,FBLN5,TIMP2,GATM,S100A4,FCGBP,UBA7,ATP1A2,CAV2,CAV2,SLC25A12,DDB2,NELL2,RBP1,MME,MME,RCAN2,EPHA2,PEX14,MET,LYST,AOC1,FEZ1,FCHSD2,FGFR2,FGFR2,BCL2,PKD2,FZD7,CEACAM6,LMOD1,MPZL2,DMD,WFDC2,HEPH,CHST2,GSTA1,BTN2A1,CELSR2,LPAR1,MEIS1,TPM2,COL7A1,TPST1,NPR2,COL16A1,TRAF5,GRK5,EFS,NEFH,GSTM1,LCAT,DST,ADCY9,PPIC,PLLP,GABRE,ST6GALNAC2,SGCE,WIF1,KRT15,PDE4A,HLF,GPRASP1,P3H3,,AOC3,MUC4,VAMP5,SRPX,KIT,KRT17,COCH,NR3C2,SPEG,KCNJ8,CRABP1,ACOX2,CFD,SCRG1,PLAU,CALD1,TAGLN,BTG3,SNX7,SCGB1A1,CYP3A5,CCK,SLC14A1,SLC18A2,PLCL1,FOXF1,DSC3,TPM1,TPM1,SEMG1,PTGER2,EPB41L3,EPHA7,SEMA3E,PPP3CC,TSC22D3,PLAGL1,CSRP2,METTL7A,RBPMS,FLNC,KRT13,MYH11,DPT,LAPTM4B,ABCC3,FGFR2,DTNA,AMY1A,PDLIM1,C1S,CAVIN1,CLU,CLU,ANXA2P2,ID1,FADS1,FADS1,KRT7,MCAM,SH3GLB1,TUBA1A,TRIP6,GPM6B,GPM6B,GPM6B,GPM6B,TUBB6,FERMT2,FERMT2,LAMB3,CRYAB,ID4,ID4,ID4,PLAGL1,KRT14,PLPP3,EFEMP2,SERPINA5,RBPMS,RBPMS,RARRES2,GATA3,TGFB1I1,PGF,DOK4,TGFB3,CHRDL1,IL33,TP63,CYP4B1,FYN,TTLL3,PMP22,ANXA2,AKAP12,CYP4F8,SYNGR1,MEG3,SSX2IP,EFS,TPM1,TPM1,TCEAL2,MCAM,COL13A1,CASP1,FGFR1,LMOD1,PDLIM4,LAMB1,CEACAM6,,TRO,TRO,PTGDS,EPB41L3,CYP3A7,MYOF,COL4A2,COL4A1,H3-3B,U2SURP,C1R,CALD1,CAV1,ATP2B4,ATP2B4,VEGFA,PLPP3,PLPP3,MAP1B,KRT17,PIK3R1,TUBA4A,DST,DST,TBC1D1,COL5A1,MXRA7,GPD1L,NEMP1,CHN1,ZCCHC14,SPARC,NCAM1,AOPEP,COL14A1,ACKR3,AHSA2P,AHNAK2,ANGPTL2,DPT,DPT,BTG3,SNAI2,ROBO1,,CTSB,VSTM4,COL6A1,SOSTDC1,ANXA2,OSR2,ZNF75D,PENK,GNAL,COL4A6,SPON1,SPON1,DES,GPR161,FERMT2,CYP3A5,CYP3A5,DKK3,ZNF204P,DST,TTC28,CALD1,GSTM1,SEMG2,LAMB2,DST,S100A6,FXYD6,SORBS1,SCPEP1,BDH2,NAV2,S100PBP,NLRP1,KANK2,CERK,KLF11,PDGFC,ANO1,VAV3,PNMA8A,DSE,KRT23,FHOD3,INAVA,CD248,ITIH5,SLC24A3,RBP4,RASL12,SCUBE2,SLCO3A1,TMEM100,FLRT3,PDGFD,FBXO2,WFDC1,SLC47A1,DUOX1,BEND5,TMEM35A,PCDH9,NDNF,CPLX3,ADAMTS5,GPR87,ECHDC1,FBXO17,LMAN1L,C1QTNF1,PER3,TNS1,CRISPLD2,KCNMA1,HSPB8,TNS1,TNS1,C2orf68,MECOM,EOGT,COL9A1,CLU,ISYNA1,CORO1C,SORBS1,SMOC1,SMOC1,GRHL1,FLRT3,CPLX3,MARVELD1,NTN4,ECRG4,SLC4A11,TRPC4,ANGPTL1,CFL2,PGAP4,ASB3,TIMP2,TNRC6A,RAB34,SH3PXD2A,DAB2IP,C12orf75,PLEKHA2,MRAS,PDK4,SLMAP,RBMS1,COL27A1,COL27A1,KIRREL1,MFSD2A,NEURL1B,MIR100HG,DDR2,FRMD6,FRMD6,EEF2K,CACHD1,CDC42EP3,FAM83D,SYNPO2,SYNPO2,MSRB3,JAZF1,JAZF1,AJUBA,RBM33,NAP1L1,SYNPO2,PRICKLE2,VANGL2,IRAG1,MAP1B,NEXN,RIMKLB,PRSS23,BNIP2,PGM5,STARD4,CLIP4,SEMA6D,ZBTB47,PODN,TAGLN,KITLG,ITGB6,SGPP2,FHDC1,DNAAF9,UBE2QL1,TGFBR3,ARHGAP23,PRRX1,CCDC50,ITGA1,CNRIP1,MIR205,CLMP,UNC5B,DMKN,SSPN,CXCL17,CCDC136,FGD5,GPC6,DTNA,PLEKHH2,CARMN,EVA1C,PRRT2,ITGA9,TSPAN18,ITGA2,TMEM200B,NCAM1,ARMCX4,FOXQ1,AKAP12,MAGI2-AS3,DDR2,NHSL2,TFCP2L1,SNORD123,SYNPO2,CPAMD8,MRGPRF,CLIC6,SORBS2,SORBS2,TMEM185A,TBC1D1,CTSB,LAYN,TGFB2,C2orf88,LSAMP,PRELP,TMEM237,ENAH,RAP1A,PGR,MYZAP,PCDH7,PREX2,CYS1,COL14A1,SLC6A6,GJC1,ARL10,TUB,NHS,WDR33,SLC14A1,EPHA7,KLHL29,SPATA18,MYOCD,HOXD10,OTULIN,ANKDD1A,PRIMA1,,GPR161,SCGB3A1,SLFN5,TNS4,ICA1L,LINC00844,PGM5-AS1,ADCY4,GALNT10,KLF8,PCAT4,ANKRD35,GPR155,TIMP2,SH3PXD2B,RAVER2,STOX2,DNM3OS,DST,,,MASP1,,EHF,,ADAM33,PARP6,ZNF395,,,KCNJ3,,,ADAM33,SBSPON,KSR1,MR1,C14orf28,CIBAR1,RHOJ,ZNF398,TXNL1,,,ITGA8,TSLP,GSTM3,MELTF,SRD5A2,WDR1,,,,HOXD13,SLC16A14,,WNT2B,,GPLD1,,EYA4,,,,,ZNF536,,,,,,ZNF827,SALL3,GLIS1,,PPP3CC,NEFH,NBL1,MRC2,AQP3,LPCAT4,TLE2,ACACB,EHD2,ACACB,ARHGEF40,MYO15B,ADGRA2,CX3CL1 FOUNDER_NAMES