STANDARD_NAME LIU_TARGETS_OF_VMYB_VS_CMYB_DN SYSTEMATIC_NAME M3258 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LIU_TARGETS_OF_VMYB_VS_CMYB_DN NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Gene regulated in the opposite directions by v-MYB (DN) and c-MYB (UP) variants of CMYB [GeneID=4602] overexpressed in primary monocyte cultures off adenoviral vectors. DESCRIPTION_FULL The v-Myb oncoprotein encoded by Avian Myeloblastosis Virus is highly oncogenic, induces leukemias in chickens and mice and transforms immature hematopoietic cells in vitro. The v-Myb protein is a mutated and truncated version of c-Myb, a DNA-binding transcription factor expressed in many cell types that is essential for normal hematopoiesis. Previous studies suggested that two types of differences, DNA binding domain mutations and the deletion of a C-terminal negative regulatory domain were important for increasing the transforming activity of v-Myb. Here, we combined structure-function studies of the v-Myb and c-Myb proteins with unbiased microarray-based transcription assays to compare the transcriptional specificities of the two proteins. In human cells, the v-Myb and c-Myb proteins displayed strikingly different activities and regulated overlapping, but largely distinct sets of target genes. Each type of mutation that distinguished v-Myb from c-Myb, including the N- and C-terminal deletions, DNA binding domain changes and mutations in the transcriptional activation domain, affected different sets of target genes and contributed to the different activities of c-Myb and v-Myb. The results suggest that v-Myb is not just a de-repressed version of c-Myb. Instead, it is a distinct transcriptional regulator with a unique set of activities. PMID 16205643 GEOID GSE2815,GSE2816 AUTHORS Liu F,Lei W,O'Rourke JP,Ness SA CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 4S: Heat Map Order 28-82 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1552274_at,1552612_at,1552613_s_at,1558871_at,200897_s_at,200906_s_at,200907_s_at,201160_s_at,201161_s_at,201461_s_at,203044_at,205207_at,205476_at,205518_s_at,205683_x_at,205899_at,206170_at,206825_at,207237_at,207901_at,208112_x_at,208763_s_at,209211_at,209277_at,209278_s_at,209386_at,209387_s_at,209604_s_at,210173_at,210229_s_at,210279_at,211571_s_at,211964_at,213915_at,214870_x_at,215034_s_at,215646_s_at,219049_at,219551_at,219890_at,220054_at,221249_s_at,221934_s_at,222221_x_at,222900_at,223058_at,223422_s_at,224579_at,224965_at,225351_at,226033_at,228176_at,229830_at,235463_s_at,236198_at GENE_SYMBOLS PXK,CDC42SE2,CDC42SE2,,PALLD,PALLD,PALLD,YBX3,YBX3,MAPKAPK2,CHSY1,IL6,CCL20,CMAHP,TPSAB1,CCNA1,ADRB2,OXTR,KCNA3,IL12B,EHD1,TSC22D3,KLF5,TFPI2,TFPI2,TM4SF1,TM4SF1,GATA3,PTPRJ,CSF2,GPR18,VCAN,COL4A2,NKG7,NPIPA1,TM4SF1,VCAN,CSGALNACT1,EAF2,CLEC5A,IL23A,FAM117A,DALRD3,EHD1,NRIP3,FAM107B,ARHGAP24,SLC38A1,GNG2,DENND10P1,USP31,S1PR3,,CERS6,LINC01215 FOUNDER_NAMES