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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="LIU_VMYB_TARGETS_UP" SYSTEMATIC_NAME="M1584" HISTORICAL_NAMES="" PMID="16205643" AUTHORS="Liu F,Lei W,O'Rourke JP,Ness SA" GEOID="GSE2815,GSE2816" EXACT_SOURCE="Table 1S: average (vMyb/Cont) &gt;= 2" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_HG_U133" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes up-regulated in MCF-7 cells (breast cancer) by overexpression of v-MYB oncogenic varian of CMYB [GeneID=4602] off adenovirus vector." DESCRIPTION_FULL="The v-Myb oncoprotein encoded by Avian Myeloblastosis Virus is highly oncogenic, induces leukemias in chickens and mice and transforms immature hematopoietic cells in vitro. The v-Myb protein is a mutated and truncated version of c-Myb, a DNA-binding transcription factor expressed in many cell types that is essential for normal hematopoiesis. Previous studies suggested that two types of differences, DNA binding domain mutations and the deletion of a C-terminal negative regulatory domain were important for increasing the transforming activity of v-Myb. Here, we combined structure-function studies of the v-Myb and c-Myb proteins with unbiased microarray-based transcription assays to compare the transcriptional specificities of the two proteins. In human cells, the v-Myb and c-Myb proteins displayed strikingly different activities and regulated overlapping, but largely distinct sets of target genes. Each type of mutation that distinguished v-Myb from c-Myb, including the N- and C-terminal deletions, DNA binding domain changes and mutations in the transcriptional activation domain, affected different sets of target genes and contributed to the different activities of c-Myb and v-Myb. The results suggest that v-Myb is not just a de-repressed version of c-Myb. Instead, it is a distinct transcriptional regulator with a unique set of activities." TAGS="" MEMBERS="200615_s_at,200762_at,201460_at,201559_s_at,201560_at,201951_at,201952_at,202208_s_at,202345_s_at,202430_s_at,202444_s_at,202468_s_at,202551_s_at,202693_s_at,202850_at,203102_s_at,203126_at,203358_s_at,203414_at,203520_s_at,203675_at,203680_at,203705_s_at,203729_at,203964_at,204062_s_at,204204_at,204208_at,204269_at,204333_s_at,204693_at,204698_at,204766_s_at,204805_s_at,204900_x_at,204949_at,205068_s_at,205090_s_at,205449_at,205573_s_at,205938_at,205968_at,206307_s_at,206662_at,207124_s_at,207904_s_at,208103_s_at,208950_s_at,209099_x_at,209105_at,209191_at,209196_at,209328_x_at,209337_at,209406_at,209409_at,209610_s_at,209628_at,209735_at,209754_s_at,210050_at,210105_s_at,210251_s_at,210959_s_at,211034_s_at,211061_s_at,211382_s_at,211406_at,211456_x_at,211538_s_at,211778_s_at,211919_s_at,212013_at,212120_at,212221_x_at,212594_at,212719_at,212817_at,212900_at,212909_at,212912_at,212916_at,213256_at,213285_at,213376_at,213435_at,213820_s_at,214061_at,214102_at,214130_s_at,214313_s_at,214434_at,214697_s_at,215009_s_at,217028_at,217223_s_at,217843_s_at,217906_at,217957_at,218035_s_at,218037_at,218228_s_at,218350_s_at,218458_at,218486_at,218582_at,218628_at,218737_at,218769_s_at,218857_s_at,218940_at,218951_s_at,218974_at,219065_s_at,219147_s_at,219229_at,219255_x_at,219282_s_at,219295_s_at,219433_at,219862_s_at,219884_at,220161_s_at,220234_at,220238_s_at,220419_s_at,220742_s_at,221478_at,221965_at,221984_s_at,222235_s_at,222279_at,33304_at,33494_at" MEMBERS_SYMBOLIZED="ABCD3,ABCG2,AGA,ALCAM,ALDH7A1,ANKRA2,ANP32E,AP2B1,ARHGAP26,ARL4C,ASRGL1,BAG2,BCOR,BNIP3L,CA8,CDC42EP1,CFAP20,CLIC4,CRIM1,CSGALNACT2,CTNNAL1,CXCR4,DNAJB5,DPYSL2,EMP3,EPB41L4B,ERLIN1,ETFDH,EZH2,FABP5,FOXD1,FYN,FZD7,GLRX,GMCL1,GMNN,GNB5,GRB10,H1-10,HECTD4,HIGD2A,HSPA12A,HSPA2,ICAM3,IDS,IL17RB,IMPA2,ISG20,JAG1,KCNS3,KLF11,KLHDC2,KLHL7,LHX6,LNPEP,LYPD1,MAPKAPK2,MARCHF3,MARCHF5,MED4,MEMO1,MGAT2,MMD,MPHOSPH9,MT1H,NAGPA,NARF,NCOA1,NGLY1,NMI,NMRK1,NUCB2,NUDT1,NXT2,OVOL2,PCOLCE2,PDCD4,PDE4DIP,PHF8,PHLPP1,PIM2,PLCXD1,PLSCR1,PPM1E,PRKAR2B,PSIP1,PTBP3,PXDN,RBM47,RETREG2,RHOQ,RNGTT,RPL23AP1,RPS6KA2,RUFY3,SAC3D1,SAP30,SATB2,SBNO1,SEC24A,SLC1A4,SLC31A2,SLCO3A1,SNX7,SOBP,SRD5A1,STARD5,STK17A,TACC2,TBC1D31,THAP9-AS1,TMEM30B,TMPO,TNKS2,TPI1,TRPV2,TUBB6,ULK2,USP25,VCPKMT,WASHC3,WDR46,ZBTB1,ZNF318" MEMBERS_EZID="100499177,10123,10198,10579,10613,10681,10802,11040,11135,11168,115123,116372,1318,161291,163,175,1808,182,192286,2014,2110,214,2146,2171,22843,22890,22902,2297,23092,23133,23239,23314,23433,23531,23588,24149,2534,25822,259217,25932,26468,26502,26577,27250,2745,28232,283450,2887,29079,29105,29761,29901,3306,3385,3423,3613,3669,3790,4012,4247,4496,4521,4925,501,51019,51053,51072,51172,51232,51375,51393,5359,54502,54566,54708,54880,54981,55084,55206,55344,55454,55540,55768,5577,55916,55975,57763,5825,58495,6148,6196,64395,6509,665,6715,7112,7167,767,7837,7852,79137,79609,80150,80351,80765,81611,8324,84617,8462,8648,8727,8732,8819,8971,9111,9261,9263,9277,93594,9429,9532,9659,9706,9991" MEMBERS_MAPPING="200615_s_at,AP2B1,163|200762_at,DPYSL2,1808|201460_at,MAPKAPK2,9261|201559_s_at,CLIC4,25932|201560_at,CLIC4,25932|201951_at,ALCAM,214|201952_at,ALCAM,214|202208_s_at,ARL4C,10123|202345_s_at,FABP5,2171|202430_s_at,PLSCR1,5359|202444_s_at,ERLIN1,10613|202468_s_at,CTNNAL1,8727|202551_s_at,CRIM1,51232|202693_s_at,STK17A,9263|202850_at,ABCD3,5825|203102_s_at,MGAT2,4247|203126_at,IMPA2,3613|203358_s_at,EZH2,2146|203414_at,MMD,23531|203520_s_at,ZNF318,24149|203675_at,NUCB2,4925|203680_at,PRKAR2B,5577|203705_s_at,FZD7,8324|203729_at,EMP3,2014|203964_at,NMI,9111|204062_s_at,ULK2,9706|204204_at,SLC31A2,1318|204208_at,RNGTT,8732|204269_at,PIM2,11040|204333_s_at,AGA,175|204693_at,CDC42EP1,11135|204698_at,ISG20,3669|204766_s_at,NUDT1,4521|204805_s_at,H1-10,8971|204900_x_at,SAP30,8819|204949_at,ICAM3,3385|205068_s_at,ARHGAP26,23092|205090_s_at,NAGPA,51172|205449_at,SAC3D1,29901|205573_s_at,SNX7,51375|205938_at,PPM1E,22843|205968_at,KCNS3,3790|206307_s_at,FOXD1,2297|206662_at,GLRX,2745|207124_s_at,GNB5,10681|207904_s_at,LNPEP,4012|208103_s_at,ANP32E,81611|208950_s_at,ALDH7A1,501|209099_x_at,JAG1,182|209105_at,NCOA1,8648|209191_at,TUBB6,84617|209196_at,WDR46,9277|209328_x_at,HIGD2A,192286|209337_at,PSIP1,11168|209406_at,BAG2,9532|209409_at,GRB10,2887|209610_s_at,SLC1A4,6509|209628_at,NXT2,55916|209735_at,ABCG2,9429|209754_s_at,TMPO,7112|210050_at,TPI1,7167|210105_s_at,FYN,2534|210251_s_at,RUFY3,22902|210959_s_at,SRD5A1,6715|211034_s_at,HECTD4,283450|211061_s_at,MGAT2,4247|211382_s_at,TACC2,10579|211406_at,null,null|211456_x_at,MT1H,4496|211538_s_at,HSPA2,3306|211778_s_at,OVOL2,58495|211919_s_at,CXCR4,7852|212013_at,PXDN,7837|212120_at,RHOQ,23433|212221_x_at,IDS,3423|212594_at,PDCD4,27250|212719_at,PHLPP1,23239|212817_at,DNAJB5,25822|212900_at,SEC24A,10802|212909_at,LYPD1,116372|212912_at,RPS6KA2,6196|212916_at,PHF8,23133|213256_at,MARCHF3,115123|213285_at,TMEM30B,161291|213376_at,ZBTB1,22890|213435_at,SATB2,23314|213820_s_at,STARD5,80765|214061_at,TBC1D31,93594|214102_at,null,null|214130_s_at,PDE4DIP,9659|214313_s_at,null,null|214434_at,HSPA12A,259217|214697_s_at,PTBP3,9991|215009_s_at,THAP9-AS1,100499177|217028_at,CXCR4,7852|217223_s_at,null,null|217843_s_at,MED4,29079|217906_at,KLHDC2,23588|217957_at,CFAP20,29105|218035_s_at,RBM47,54502|218037_at,RETREG2,79137|218228_s_at,TNKS2,80351|218350_s_at,GMNN,51053|218458_at,GMCL1,64395|218486_at,KLF11,8462|218582_at,MARCHF5,54708|218628_at,WASHC3,51019|218737_at,SBNO1,55206|218769_s_at,ANKRA2,57763|218857_s_at,ASRGL1,80150|218940_at,VCPKMT,79609|218951_s_at,PLCXD1,55344|218974_at,SOBP,55084|219065_s_at,MEMO1,51072|219147_s_at,NMRK1,54981|219229_at,SLCO3A1,28232|219255_x_at,IL17RB,55540|219282_s_at,TRPV2,51393|219295_s_at,PCOLCE2,26577|219433_at,BCOR,54880|219862_s_at,NARF,26502|219884_at,LHX6,26468|220161_s_at,EPB41L4B,54566|220234_at,CA8,767|220238_s_at,KLHL7,55975|220419_s_at,USP25,29761|220742_s_at,NGLY1,55768|221478_at,BNIP3L,665|221965_at,MPHOSPH9,10198|221984_s_at,RETREG2,79137|222235_s_at,CSGALNACT2,55454|222279_at,RPL23AP1,6148|33304_at,ISG20,3669|33494_at,ETFDH,2110" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
