STANDARD_NAME	LI_INDUCED_T_TO_NATURAL_KILLER_UP
SYSTEMATIC_NAME	M2086
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LI_INDUCED_T_TO_NATURAL_KILLER_UP
NAMESPACE	MOUSE_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in ITNK cells (T-lymphocyte progenitors (DN3 cells) reprogrammed to natural killer (NK) cells by ablation of BCL11B [GeneID=64919] gene), compared to the parental DN3 cells.
DESCRIPTION_FULL	T cells develop in the thymus and are critical for adaptive immunity. Natural killer (NK) lymphocytes constitute an essential component of the innate immune system in tumor surveillance, reproduction, and defense against microbes and viruses. Here, we show that the transcription factor Bcl11b was expressed in all T cell compartments and was indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.
PMID	20538915
GEOID	GSE21016
AUTHORS	Li P,Burke S,Wang J,Chen X,Ortiz M,Lee SC,Lu D,Campos L,Goulding D,Ng BL,Dougan G,Huntly B,Gottgens B,Jenkins NA,Copeland NG,Colucci F,Liu P
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S: ITNK vs DN3 Ratio > 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	0610007H07Rik,0610009O03Rik,0610037M15Rik,0610039P13Rik,1110004P15Rik,1110007C02Rik,1110008P14Rik,1110018K11Rik,1110019C08Rik,1110020C13Rik,1110030J09Rik,1190002C06Rik,1300002F13Rik,1500031H04Rik,1700017I11Rik,1700025G04Rik,2210008N01Rik,2210411K11Rik,2310037P21Rik,2310046K01Rik,2310047C17Rik,2310057H16Rik,2310061M23Rik,2310067E08Rik,2410008K03Rik,2610009E16Rik,2810032E02Rik,2810440J20Rik,2900026A02Rik,3010031K01Rik,4631423F02Rik,4930486L24Rik,4930504E06Rik,4930555L03Rik,4933439K08Rik,5330403J18Rik,7420404O03Rik,9130211I03Rik,9130227C08Rik,9130404D14Rik,9930117H01Rik,A230057G18Rik,A330042I21Rik,A430038C16Rik,A630077B13Rik,A930008A22Rik,AA175286,AA467197,Ahnak,AI115600,AI481100,AI840980,AI847670,AI850995,Aim1,Aim1l,Aldoa,Amica1,Ank,Anxa2,Apob48r,Aqp9,Arap3,Arf6,Arl6ip5,Asah1,Asb2,Avil,AW212394,B3gnt8,B4galnt2,B4galnt4,B830021E24Rik,Bag3,Batf,Batf3,BC017612,BC021614,BC024955,BC025206,BC038881,BC049975,Bhlhb2,Blr1,Bscl2,C130027E04Rik,C330008K14Rik,C330023F11Rik,Capg,Capn2,Capns1,Capzb,Casp1,Ccdc102a,Ccdc132,Ccl3,Ccl4,Ccl5,Ccnd2,Ccng1,Ccr5,Cd160,Cd244,Cd52,Cd63,Cd69,Cd7,Cd9,Cdkn1a,Cdkn2a,Cdkn2b,Chsy1,Cish,Clnk,Comt,Coro1c,Cotl1,Cstb,Ctgf,Ctnna1,Ctsw,Cx3cr1,Cxcl9,Cxcr3,Cyb5r4,Cyp51,D10Bwg1379e,D14ertd449e,D15mgi27,D2Ertd217e,D930046M13Rik,Dapk2,Dci,Dcxr,Degs,Dhrs11,Dok2,Dp1,Dusp5,Dusp6,Dyrk3,E030003N15Rik,E030006K04Rik,E130012A19Rik,E430036I04Rik,EG331493,EG630499,Egr1,Egr3,Ehd4,Elovl1,Emilin2,Emp1,Evi2a,F2r,F2rl2,F630022B06Rik,Fam105b,Fam20a,Fam46a,Fcer1g,Fcgr3,Fes,Fhl2,Fnbp1,Fosl2,Ftl1,Furin,Fxyd4,Fxyd5,Gadd45g,Gbp2,Gcnt1,Gcnt2,Glipr1,Glipr2,Glrx,Glrx1,Gm19590,Gm4777,Gng2,Golph2,Gpc1,Gpr114,Gpr18,Gpr34,Gpr68,Gpr97,Gvin1,H2-GS17,H2-Q6,H2-Q7,H2-Q8,H47,Haao,Havcr2,Hba-a1,Hgfac,Hhex,Hist1h1c,Hk2,Hmgcs1,Hrmt1l1,Hsd11b1,Hvcn1,Id2,Idb2,Ier3,Ifi30,Ifitm1,Ifitm2,Ifitm3,Ifng,Il18r1,Iqgap2,Irak2,Itgad,Itgae,Itgb7,Junb,Kctd10,Kirl2,Kit,Klrd1,Klre1,Lag3,Lasp1,Lgals1,Lgals3,Lgals3bp,Litaf,Lmna,LOC215405,LOC218482,LOC327957,LOC328703,LOC383099,LOC383189,LOC383981,LOC385699,LOC385953,Lrp12,Lrrk1,Lta,Ltb4r1,Ly6a,Ly6g5b,Mapkapk3,Med10,Mina,Mlkl,Mt1,Mvp,Myl6,Myo1e,Myo1f,Myo1g,N4wbp5,Napsa,Ncf4,Ndfip1,Neurl3,Nfil3,Nfkb1,Nkg7,Nrgn,Nt5e,Osbpl3,Osm,Ostf1,P2ry14,Pdgfa,Pdlim7,Pdzk1,Pea15,Pglyrp1,Pilrb,Pim3,Pkp3,Plcg2,Plp2,Plscr1,Pltp,Ppap2c,Ppib,Ppp3cc,Prdx4,Prr7,Prss19,Rab19,Rab3d,Rab4a,Rbms1,Rgs1,Rhof,Rog,Rom1,S100a1,S100a10,S100a11,S100a13,S100a4,S100a6,Sc4mol,Scin,Scl0001419.1_32,Sdf2l1,Sec61b,Sema4a,Serpina3g,Serpinb6a,Serpine2,Sertad1,Sgk,Sh2d1b1,Sh3bgrl3,Sh3bp2,Siat10,Sirt3,Slamf7,Slc19a2,Slc24a3,Slc2a6,Slc39a4,Smagp,Snag1,Spp1,Srgap2,Stx11,Stx7,Sult2b1,Sypl,Sytl2,Taf9b,Tcrd-v1,Tes,Tiam1,Tmem126a,Tmpit,Tnf,Tnfrsf11b,Tnfrsf18,Tnfrsf22,Tnfrsf9,Tpst2,Traf1,Trf,Trpm6,Tspo,Tuba6,Tyrobp,Uap1l1,Upp1,Vim,Vps29,Vti1b,Wbscr5,Xbp1,Xcl1,Zbtb32,Zfp296,Zfp608
GENE_SYMBOLS	TMBIM4,MFSD10,HLA-B,HVCN1,AHNAK,ARSB,BBLN,HOPX,CLDND1,PRR13,MED11,PRRC1,ERRFI1,ZCCHC18,SUSD3,C1orf21,,TMEM238,TMEM158,SLC52A3,AHNAK,TUBB6,,ENDOD1,CASTOR1,PTMS,SERP2,SUSD3,KIAA1671,,KLHL30,,MINDY1,RNF19B,GPR15,,,BATF3,KHNYN,NIBAN2,TMEM154,MIAT,TNFSF10,,CALHM6,GRAMD1B,SAMD9L,C15orf48,DENND4A,IRGM,PLEKHO2,FAM185A,GFOD1,,AHNAK,CRYBG1,CRYBG2,ALDOA,JAML,ANKH,ANXA2,APOBR,AQP9,ARAP3,ARF6,ARL6IP5,ASAH1,ASB2,AVIL,B3GNT8,B4GALNT2,B4GALNT4,SIDT1,SMCO4,GSTP1,GDPD5,B3GNT8,B4GALNT4,SERPINA3,BAG3,BATF,BATF3,BHLHE40,CXCR5,BSCL2,TIRAP,PRELID2,SCCPDH,CAPG,CAPN2,CAPNS1,CAPZB,CASP1,CCDC102A,VPS50,CCL3,CCL4,CCL5,CCND2,CCNG1,CCR5,CD160,CD244,CD52,CD63,CD69,CD7,CD9,CDKN1A,CDKN2A,CDKN2B,CHSY1,CISH,CLNK,COMT,CORO1C,COTL1,CSTB,CCN2,CTNNA1,CTSW,CX3CR1,CXCL9,CXCR3,CYB5R4,CYP51A1,ARFGEF3,,,TMEM141,VASH1,DAPK2,ECI1,DCXR,,DHRS11,DOK2,TFDP1,DUSP5,DUSP6,DYRK3,DENND3,ARAP3,EPOP,LRRC8C,,,EGR1,EGR3,EHD4,ELOVL1,EMILIN2,EMP1,EVI2A,F2R,F2RL2,PIGZ,OTULIN,FAM20A,TENT5A,FCER1G,FCGR2A,FES,FHL2,FNBP1,FOSL2,FTL,FURIN,FXYD4,FXYD5,GADD45G,GBP2,GCNT1,GCNT2,GLIPR1,GLIPR2,GLRX,,,,GNG2,GOLM1,GPC1,ADGRG5,GPR18,GPR34,GPR68,ADGRG3,,,HLA-B,HLA-B,HLA-B,SELENOS,HAAO,HAVCR2,HBA2,HGFAC,HHEX,H1-2,HK2,HMGCS1,PRMT2,HSD11B1,HVCN1,ID2,ID2,IER3,IFI30,IFITM1,IFITM2,IFITM3,IFNG,IL18R1,IQGAP2,IRAK2,ITGAD,ITGAE,ITGB7,JUNB,KCTD10,KIR3DL3,KIT,KLRD1,,,,SCIMP,,,,,,GPR15,LAG3,LASP1,LGALS1,LGALS3,LGALS3BP,LITAF,LMNA,LRP12,LRRK1,LTA,LTB4R,,LY6G5B,MAPKAPK3,MED10,RIOX2,MLKL,MT1F,MVP,MYL6,MYO1E,MYO1F,MYO1G,,NAPSA,NCF4,NDFIP1,NEURL3,NFIL3,NFKB1,NKG7,NRGN,NT5E,OSBPL3,OSM,OSTF1,P2RY14,PDGFA,PDLIM7,PDZK1,PEA15,PGLYRP1,,PIM3,PKP3,PLCG2,PLP2,PLSCR1,PLTP,PLPP2,PPIB,PPP3CC,PRDX4,PRR7,KLK8,RAB19,RAB3D,RAB4A,RBMS1,RGS1,RHOF,ZBTB32,ROM1,S100A1,S100A10,S100A11,S100A13,S100A4,S100A6,MSMO1,SCIN,,SDF2L1,SEC61B,SEMA4A,SERPINA3,SERPINB6,SERPINE2,SERTAD1,SGK1,SH2D1B,SH3BGRL3,SH3BP2,ST3GAL6,SIRT3,SLAMF7,SLC19A2,SLC24A3,SLC2A6,SLC39A4,SMAGP,SNX18,SPP1,SRGAP2,STX11,STX7,SULT2B1,SYPL1,SYTL2,TAF9B,,TES,TIAM1,TMEM126A,TMEM120A,TNF,TNFRSF11B,TNFRSF18,,TNFRSF9,TPST2,TRAF1,TF,TRPM6,TSPO,TUBA1C,TYROBP,UAP1L1,UPP1,VIM,VPS29,VTI1B,LAT2,XBP1,XCL1,ZBTB32,ZNF296,ZNF608
FOUNDER_NAMES