STANDARD_NAME LI_PBMC_ZOSTAVAX_AGE_25_40_AND_60_79YO_1DY_UP SYSTEMATIC_NAME M41124 COLLECTION C7:VAX MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LI_PBMC_ZOSTAVAX_AGE_25_40_AND_60_79YO_1DY_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in peripheral blood mononuclear cell 1d vs 0d in adults (25-40/60-79) after exposure to Zostavax , time point 1D DESCRIPTION_FULL Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available for prevention of shingles, its efficacy declines with age. To help to understand the mechanisms driving vaccinal responses, we constructed a multiscale, multifactorial response network (MMRN) of immunity in healthy young and older adults immunized with the live attenuated shingles vaccine Zostavax. Vaccination induces robust antigen-specific antibody, plasmablasts, and CD4+ T cells yet limited CD8+ T cell and antiviral responses. The MMRN reveals striking associations between orthogonal datasets, such as transcriptomic and metabolomics signatures, cell populations, and cytokine levels, and identifies immune and metabolic correlates of vaccine immunity. Networks associated with inositol phosphate, glycerophospholipids, and sterol metabolism are tightly coupled with immunity. Critically, the sterol regulatory binding protein 1 and its targets are key integrators of antibody and T follicular cell responses. Our approach is broadly applicable to study human immunity and can help to identify predictors of efficacy as well as mechanisms controlling immunity to vaccination. PMID 28502771 GEOID AUTHORS Li S,Sullivan NL,Rouphael N,Yu T,Banton S,Maddur MS,McCausland M,Chiu C,Canniff J,Dubey S,Liu K,Tran V,Hagan T,Duraisingham S,Wieland A,Mehta AK,Whitaker JA,Subramaniam S,Jones DP,Sette A,Vora K,Weinberg A,Mulligan MJ,Nakaya HI,Levin M,Ahmed R,Pulendran B CONTRIBUTOR HIPC SIGNATURES CONTRIBUTOR_ORG NIAID/HIPC SIGNATURES EXACT_SOURCE Suppl Fig 2A FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711477/bin/NIHMS871779-supplement-2.tiff SOURCE_MEMBERS CCL5,GZMH,MYO6,PSPH,S1PR5,SLC22A16,TARP GENE_SYMBOLS CCL5,GZMH,MYO6,PSPH,S1PR5,SLC22A16,TARP FOUNDER_NAMES