STANDARD_NAME LUI_THYROID_CANCER_CLUSTER_5 SYSTEMATIC_NAME M13462 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LUI_THYROID_CANCER_CLUSTER_5 NAMESPACE AFFY_HG_U95 DESCRIPTION_BRIEF Cluster 5: genes with similar expression profiles across follicular thyroid carcinoma (FTC) samples. DESCRIPTION_FULL The demonstration of the PAX8-PPAR(gamma) fusion oncogene in a subset of follicular thyroid tumors provides a new and promising starting point to dissect the molecular genetic events involved in the development of this tumor form. In the present study, we compared the gene expression profiles of follicular thyroid carcinomas (FTCs) bearing a PAX8-PPAR(gamma) fusion against FTCs that lack this fusion. Using unsupervised clustering and multidimensional scaling analyses, we show that FTCs possessing a PAX8-PPAR(gamma) fusion have a highly uniform and distinct gene expression signature that clearly distinguishes them from FTCs without the fusion. The PAX8-PPAR(gamma)(+) FTCs grouped in a defined cluster, where highly ranked genes were mostly associated with signal transduction, cell growth and translation control. Notably, a large number of ribosomal protein and translation-associated genes were concurrently underexpressed in the FTCs with the fusion. Taken together, our findings further support that follicular carcinomas with a PAX8-PPAR(gamma) rearrangement constitute a distinct biological entity. The current data represent one step to elucidate the molecular pathways in the development of FTCs with the specific PAX8-PPAR(gamma) fusion. PMID 15608688 GEOID AUTHORS Lui WO,Foukakis T,Lidén J,Thoppe SR,Dwight T,Höög A,Zedenius J,Wallin G,Reimers M,Larsson C CONTRIBUTOR Leona Saunders CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1S: Cluster 5 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 32242_at,32243_g_at,33261_at,33412_at,34775_at,35345_at,35950_at,36170_at,37002_at,37344_at,37532_at,37897_s_at,38636_at,38790_at,39566_at,39568_g_at,39990_at GENE_SYMBOLS CRYAB,CRYAB,HLA-DRB1,LGALS1,TSPAN1,HMGCS2,SSX1,ETHE1,BLVRB,HLA-DMA,ACADM,TFF3,ISLR,EPHX1,CHRNA7,AQP7,ISL1 FOUNDER_NAMES