STANDARD_NAME LU_EZH2_TARGETS_UP SYSTEMATIC_NAME M2139 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/LU_EZH2_TARGETS_UP NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF Genes up-regulated in SKOV3ip1 cells (ovarian cancer) upon knockdown of EZH2 [GeneID=2146] by RNAi. DESCRIPTION_FULL Although VEGF-targeted therapies are showing promise, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homolog 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome. The increase in endothelial EZH2 is a direct result of VEGF stimulation by a paracrine circuit that promotes angiogenesis by methylating and silencing vasohibin1 (vash1). Ezh2 silencing in the tumor-associated endothelial cells inhibited angiogenesis mediated by reactivation of VASH1, and reduced ovarian cancer growth, which is further enhanced in combination with ezh2 silencing in tumor cells. Collectively, these data support the potential for targeting ezh2 as an important therapeutic approach. PMID 20708159 GEOID GSE20381 AUTHORS Lu C,Han HD,Mangala LS,Ali-Fehmi R,Newton CS,Ozbun L,Armaiz-Pena GN,Hu W,Stone RL,Munkarah A,Ravoori MK,Shahzad MM,Lee JW,Mora E,Langley RR,Carroll AR,Matsuo K,Spannuth WA,Schmandt R,Jennings NB,Goodman BW,Jaffe RB,Nick AM,Kim HS,Guven EO,Chen YH,Li LY,Hsu MC,Coleman RL,Calin GA,Denkbas EB,Lim JY,Lee JS,Kundra V,Birrer MJ,Hung MC,Lopez-Berestein G,Sood AK CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Fig 5SJ: personal communication FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 10169,10211,1025,10273,10287,10467,10471,10534,10549,10598,10654,10763,11011,11033,11054,11068,11078,11098,11152,112464,112597,112703,112752,113000,113146,113189,113451,113655,114783,114794,114879,115286,116138,116238,1174,118881,121642,124944,125875,126003,126119,126789,126823,128439,1366,1368,140465,1415,1442,1445,147166,149466,150274,1545,164091,1646,1649,1675,200185,200316,201161,2021,2029,203260,2109,219654,219743,220988,221468,2243,22927,23048,23193,23361,23386,253827,25776,25873,2592,25966,26136,26147,26227,26262,2644,26472,2683,27018,27147,2767,283212,283596,283643,284110,285755,2872,29781,29796,29937,3049,3065,339229,3429,3430,3434,3437,348235,3607,3665,374875,375260,386608,386757,389206,389293,389541,389692,399664,399909,4000,400629,400721,4062,4071,4145,414919,4255,4350,440927,441150,4521,4580,4622,4702,475,4831,4832,4957,4968,50,50486,50512,50848,50854,50855,51005,5106,51112,51259,51282,51385,51596,51657,51690,5211,5307,5432,54344,54509,54541,54663,54985,55011,55111,55170,5520,5534,5558,55653,55754,55766,55898,55954,5600,5695,5696,5698,5699,56993,5702,57026,5710,57184,57584,57761,57801,5892,5919,5920,59307,60370,6199,6273,6275,6277,6284,638,6385,6391,641522,64222,642331,642441,642755,643161,643479,644511,6457,646407,64648,64777,647987,649049,650230,653375,653752,65989,6623,6648,666,6835,684,6923,6942,7004,7016,7159,7171,7205,7286,7692,7784,7867,7905,79078,79228,79447,79629,79746,79763,79888,8148,81552,81577,81858,8209,8338,83460,83606,8372,840,84058,84152,84263,84264,84268,84287,84292,84299,84316,84321,84331,84717,84844,84909,84915,8496,84987,85014,85364,8607,8638,8692,873,8859,8870,9022,90317,90416,9048,91107,91582,9183,9221,9246,93082,93210,9361,93622,93659,9409,94115,9507,9636,9645,968,9908 GENE_SYMBOLS SERF2,FLOT1,CDK9,STUB1,RGS19,ZNHIT1,PFDN6,ZNRD2,PRDX4,AHSA1,PMVK,NES,TLK2,ADAP1,OGFR,CYB561D2,TRIOBP,PRSS23,WDR45,CAVIN3,CYTOR,GARIN5A,IFT43,RPUSD1,AHNAK2,CHST14,AZIN2,MFSD3,LMTK3,ELFN2,OSBPL5,SLC25A26,KLHDC3,TLCD1,AP1S1,COMTD1,ALKBH2,C17orf49,CLDND2,TRAPPC5,JOSD2,PUSL1,KLHDC9,SNHG11,CLDN7,CPM,MYL6B,CRYBB2,CSH1,CSK,TRIM16L,C1orf210,HSCB,CYP1B1,PAQR7,AKR1C2,DDIT3,CFD,KRTCAP2,APOBEC3F,CENPV,ENDOG,ENSA,CCDC107,ETFB,ZCCHC24,TYSND1,HNRNPA3,TMEM217,FGA,HABP4,FNBP1,GANAB,ZNF629,NUDCD3,MSRB3,CBY1,RPL36,GALT,C2CD2,TES,PHF19,PHGDH,TSPAN17,GCHFR,PPP1R14B,B4GALT1,BEX3,DENND2A,GNA11,KLHL35,SNHG10,TEDC1,GSDMA,PPIL6,MKNK2,NCAPH2,UQCR10,NENF,HBQ1,HDAC1,OXLD1,IFI27,IFI35,IFIT1,IFIT3,SKA2,FOXK2,IRF7,HSD11B1L,WASH2P,RNASEH2CP1,SLC6A10P,BEND4,ISCA1P1,LAMTOR4,MAFA,MEX3D,PCNX3,LMNA,TEX19,ZNF814,LY6H,TM4SF1,MATK,C8orf82,MGMT,MPG,,C6orf226,NUDT1,MTX1,MYH4,NDUFA8,ATOX1,NME2,NME3,ODF2,OGG1,ACO2,G0S2,PODXL2,F11R,SNHG32,PARD6A,AMDHD2,PCK2,TRAPPC12,TMEM216,SCAND1,ZNF589,CUTA,STYXL1,LSM7,PFKL,PITX1,POLR2C,DPM3,RHOF,DDIT4,WDR74,HCFC1R1,PIH1D1,PLEKHJ1,PRMT6,PPP2R2A,PPP3R1,PRIM2,BCAS4,TMEM30A,H2AJ,UNC45A,ZMAT5,MAPK11,PSMB7,PSMB8,PSMB9,PSMB10,TOMM22,PSMC3,PDXP,PSMD4,FAM219B,ARHGAP21,TRIB3,HES4,RAD51D,RARRES2,PLAAT4,SIGIRR,AVPI1,RPS6KB2,S100A2,S100A4,S100A6,S100A13,BIK,SDC4,SDHC,ARL17B,TOR3A,,,,FAM25A,FAM25EP,RPL13AP6,SH3GL3,,SPANXD,RMND5B,,RPLP0P6,,RCC1L,,DLK2,SNCG,SOD2,BOK,SURF2,BST2,ELOB,TCF20,TEAD4,TESK1,TP53BP2,TPM4,TRIP6,TUFT1,ZNF133,ZP3,MAPKAPK3,REEP5,C1orf50,THOC6,PAGR1,OCEL1,ECHDC3,ISOC2,LPCAT1,TAF15,VOPP1,GFOD2,SHARPIN,GATD3,H2AC20,EMC6,GUCD1,HYAL3,CASP7,WDR54,PPP1R1B,HSDL2,HAGHL,RPAIN,ZDHHC16,WDR83,MIEN1,NAA38,THOC3,MCRIP2,HDGFL2,PHF5A,AOPEP,FAM222A,PPFIBP1,COX14,TMEM141,ZCCHC3,RUVBL1,OASL,HYAL2,CBR1,STK19,IER3,CLIC3,ZNF616,CCDC32,ARTN,TRIM47,RPS19BP1,ZW10,NOLC1,UBE2L6,NEURL3,PGAP3,LONP1,ENSG00000170846,CGB5,PEX16,CGB8,ADAMTS4,ISG15,MICAL2,CD68,G3BP2 FOUNDER_NAMES